2-methyl-5-ht has been researched along with Vomiting in 9 studies
2-methyl-5-HT: M-receptor agonist
Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Activation of serotonergic 5-HT3 receptors by its selective agonist 2-methyl serotonin (2-Me-5-HT) induces vomiting, which is sensitive to selective antagonists of both 5-HT3 receptors (palonosetron) and L-type calcium channels (LTCC) (amlodipine or nifedipine)." | 3.81 | L-type calcium channels contribute to 5-HT3-receptor-evoked CaMKIIα and ERK activation and induction of emesis in the least shrew (Cryptotis parva). ( Chebolu, S; Darmani, NA; Hutchinson, TE; Wilson, SM; Zhong, W, 2015) |
| "The antiemetic activity of N-3389 (endo-3,9-dimethyl-3,9-diazabicyclo[3,3,1]non-7-yl-1 H-indazole-3-carboxamide dihydrochloride), a new 5-HT3 and 5-HT4 receptor antagonist, against cisplatin-, cyclophosphamide- and copper sulfate-induced emesis was investigated using ferrets." | 3.69 | Antiemetic effects of N-3389, a newly synthesized 5-HT3 and 5-HT4 receptor antagonist, in ferrets. ( Endo, T; Hagihara, K; Hamaue, N; Hirafuji, M; Minami, M; Monma, Y; Ogawa, T; Tamakai, H; Yoshioka, M, 1997) |
| " The antiemetic dose-response curves of tropisetron against both emetogens were U-shaped probably because larger doses of this antagonist behave as a partial agonist." | 1.37 | Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva). ( Alkam, T; Amos, B; Chebolu, S; Darmani, NA, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hutchinson, TE | 1 |
| Zhong, W | 1 |
| Chebolu, S | 2 |
| Wilson, SM | 1 |
| Darmani, NA | 2 |
| Amos, B | 1 |
| Alkam, T | 1 |
| Eglen, RM | 1 |
| Lee, CH | 1 |
| Smith, WL | 1 |
| Johnson, LG | 1 |
| Clark, R | 1 |
| Whiting, RL | 1 |
| Hegde, SS | 1 |
| Ito, C | 1 |
| Isobe, Y | 1 |
| Kijima, H | 1 |
| Kiuchi, Y | 1 |
| Ohtsuki, H | 1 |
| Kawamura, R | 1 |
| Tsuchida, K | 1 |
| Higuchi, S | 1 |
| Minami, M | 1 |
| Endo, T | 1 |
| Tamakai, H | 1 |
| Ogawa, T | 1 |
| Hamaue, N | 1 |
| Hirafuji, M | 1 |
| Monma, Y | 1 |
| Yoshioka, M | 1 |
| Hagihara, K | 1 |
| Miller, AD | 1 |
| Nonaka, S | 1 |
| King, GL | 1 |
| Cohen, ML | 1 |
| Bloomquist, W | 1 |
| Gidda, JS | 1 |
| Lacefield, W | 1 |
| Higgins, GA | 1 |
| Kilpatrick, GJ | 1 |
| Bunce, KT | 1 |
| Jones, BJ | 1 |
| Tyers, MB | 1 |
9 other studies available for 2-methyl-5-ht and Vomiting
| Article | Year |
|---|---|
L-type calcium channels contribute to 5-HT3-receptor-evoked CaMKIIα and ERK activation and induction of emesis in the least shrew (Cryptotis parva).
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Stem; Calcium Channel Blockers; Calciu | 2015 |
Synergistic antiemetic interactions between serotonergic 5-HT3 and tachykininergic NK1-receptor antagonists in the least shrew (Cryptotis parva).
Topics: Analysis of Variance; Animals; Antiemetics; Dose-Response Relationship, Drug; Drug Synergism; Female | 2011 |
Pharmacological characterization of RS 25259-197, a novel and selective 5-HT3 receptor antagonist, in vivo.
Topics: Administration, Oral; Animals; Bradycardia; Dogs; Dose-Response Relationship, Drug; Duodenum; Female | 1995 |
The anti-emetic activity of GK-128 in Suncus murinus.
Topics: Animals; Antiemetics; Chromones; Cisplatin; Copper; Copper Sulfate; Cyclophosphamide; Dose-Response | 1995 |
Antiemetic effects of N-3389, a newly synthesized 5-HT3 and 5-HT4 receptor antagonist, in ferrets.
Topics: 5-Methoxytryptamine; Animals; Antiemetics; Antineoplastic Agents; Bridged Bicyclo Compounds, Heteroc | 1997 |
Mechanisms of vomiting induced by serotonin-3 receptor agonists in the cat: effect of vagotomy, splanchnicectomy or area postrema lesion.
Topics: Animals; Biguanides; Cats; Cerebral Ventricles; Female; Male; Serotonin; Serotonin Antagonists; Spla | 1992 |
Emesis and defecations induced by the 5-hydroxytryptamine (5-HT3) receptor antagonist zacopride in the ferret.
Topics: Administration, Oral; Animals; Antiemetics; Benzamides; Bridged Bicyclo Compounds; Bridged Bicyclo C | 1990 |
LY277359 maleate: a potent and selective 5-HT3 receptor antagonist without gastroprokinetic activity.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ri | 1990 |
5-HT3 receptor antagonists injected into the area postrema inhibit cisplatin-induced emesis in the ferret.
Topics: Animals; Apomorphine; Autoradiography; Brain Chemistry; Carnivora; Cisplatin; Female; Ferrets; Injec | 1989 |