2-methyl-5-ht has been researched along with Muscle Contraction in 29 studies
2-methyl-5-HT: M-receptor agonist
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| ") dosing to rats." | 1.29 | Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist. ( Kadowaki, M; Kohsaka, M; Mori, J; Nagakura, Y; Tokoro, K; Tomoi, M, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 23 (79.31) | 18.2507 |
| 2000's | 6 (20.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wainscott, DB | 1 |
| Cohen, ML | 4 |
| Schenck, KW | 1 |
| Audia, JE | 1 |
| Nissen, JS | 1 |
| Baez, M | 1 |
| Kursar, JD | 1 |
| Lucaites, VL | 1 |
| Nelson, DL | 1 |
| Molaei, G | 1 |
| Lange, AB | 1 |
| Mahesh, R | 1 |
| Perumal, RV | 1 |
| Pandi, PV | 1 |
| Delgado, M | 1 |
| Caicoya, AG | 1 |
| Greciano, V | 1 |
| Benhamú, B | 1 |
| López-Rodríguez, ML | 1 |
| Fernández-Alfonso, MS | 1 |
| Pozo, MA | 1 |
| Manzanares, J | 1 |
| Fuentes, JA | 1 |
| Ramírez, MJ | 1 |
| Cenarruzabeitia, E | 1 |
| Del Río, J | 1 |
| Lasheras, B | 1 |
| Messori, E | 1 |
| Rizzi, CA | 1 |
| Candura, SM | 1 |
| Lucchelli, A | 1 |
| Balestra, B | 1 |
| Tonini, M | 1 |
| Buchheit, KH | 2 |
| Buhl, T | 1 |
| Desai, KM | 1 |
| Warner, TD | 1 |
| Vane, JR | 1 |
| Nagakura, Y | 2 |
| Kadowaki, M | 1 |
| Tokoro, K | 1 |
| Tomoi, M | 1 |
| Mori, J | 1 |
| Kohsaka, M | 1 |
| Carter, D | 1 |
| Champney, M | 1 |
| Hwang, B | 1 |
| Eglen, RM | 1 |
| Ishizawa, M | 2 |
| Brownhill, VR | 1 |
| Hourani, SM | 1 |
| Kitchen, I | 1 |
| Sevcík, J | 1 |
| Ruzicka, V | 1 |
| Slánsky, J | 1 |
| Masek, K | 1 |
| González, AA | 1 |
| Puig, MM | 1 |
| Briejer, MR | 1 |
| Mathis, C | 1 |
| Schuurkes, JA | 1 |
| Karlsson, C | 1 |
| Bodelsson, G | 1 |
| Bodelsson, M | 1 |
| Stjernquist, M | 1 |
| Yuan, YM | 2 |
| Xu, DY | 1 |
| Hu, GY | 2 |
| Yang, HH | 1 |
| O'Gara, BA | 1 |
| Illuzzi, FA | 1 |
| Chung, M | 1 |
| Portnoy, AD | 1 |
| Fraga, K | 1 |
| Frieman, VB | 1 |
| Ito, H | 1 |
| Kiso, T | 1 |
| Miyata, K | 1 |
| Kamato, T | 1 |
| Yuki, H | 1 |
| Akuzawa, S | 1 |
| Yamano, M | 1 |
| Suzuki, M | 1 |
| Naitoh, Y | 1 |
| Sakai, H | 1 |
| Iwaoka, K | 1 |
| Yamaguchi, T | 1 |
| Bymaster, FP | 1 |
| Falcone, JF | 1 |
| Bauzon, D | 1 |
| Kennedy, JS | 1 |
| Schenck, K | 1 |
| DeLapp, NW | 1 |
| Seo, K | 1 |
| Fujiwara, N | 1 |
| Hu, JW | 1 |
| Cairns, BE | 1 |
| Someya, G | 1 |
| Mizutani, M | 1 |
| Neya, T | 1 |
| Nakayama, S | 1 |
| Tadipatri, S | 1 |
| Feniuk, W | 1 |
| Saxena, PR | 1 |
| Gamse, R | 1 |
| Pfannkuche, HJ | 1 |
| Fox, A | 1 |
| Morton, IK | 1 |
| Bloomquist, W | 1 |
| Gidda, JS | 1 |
| Lacefield, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Aprepitant- and Olanzapine- Containing Regimens for Prevention of Acute and Delayed Nausea and Vomiting Associated With High Dose Melphalan and BEAM in Autologous Stem Cell Transplant Patients[NCT02939287] | Phase 3 | 429 participants (Actual) | Interventional | 2017-09-23 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
29 other studies available for 2-methyl-5-ht and Muscle Contraction
| Article | Year |
|---|---|
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; | 1993 |
The association of serotonin with the alimentary canal of the African migratory locust, Locusta migratoria: distribution, physiology and pharmacological profile.
Topics: Animals; Digestive System; Dose-Response Relationship, Drug; Electrophysiology; Female; Grasshoppers | 2003 |
Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist.
Topics: Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Molecular Structure; Muscle Contraction; Mus | 2004 |
Anxiolytic-like effect of a serotonergic ligand with high affinity for 5-HT1A, 5-HT2A and 5-HT3 receptors.
Topics: 3,4-Dihydroxyphenylacetic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Adenylyl Cyclase Inhibitors; | 2005 |
Involvement of neurokinins in the non-cholinergic response to activation of 5-HT3 and 5-HT4 receptors in guinea-pig ileum.
Topics: 5-Methoxytryptamine; Acetylcholine; Animals; Atropine; Autonomic Nervous System; Choline; Female; Gu | 1994 |
5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Amphetamines; Animals; Dose-Response Relationship, Drug; Elec | 1995 |
Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro.
Topics: 4-Aminobenzoic Acid; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Atropine; Benzamides; Binding | 1994 |
5-HT3 receptors do not mediate vagally-induced relaxation or contraction of the isolated stomach of the guinea-pig.
Topics: Animals; Dimethylphenylpiperazinium Iodide; Electric Stimulation; In Vitro Techniques; Male; Metoclo | 1994 |
Pharmacological characterization of FK1052, a dihydropyridoindole derivative, as a new serotonin 3 and 4 dual receptor antagonist.
Topics: 5-Methoxytryptamine; Acetylcholine; Animals; Bradycardia; Electric Stimulation; Guinea Pigs; Histami | 1993 |
Characterization of a postjunctional 5-HT receptor mediating relaxation of guinea-pig isolated ileum.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Cloning, Molecular; Drug Inter | 1995 |
Inhibitory action of 5-hydroxytryptamine on propulsive activity of the guinea-pig isolated colon.
Topics: 5-Methoxytryptamine; Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniq | 1996 |
Selective enhancement by an adenosine A1 receptor agonist of agents inducing contraction of the rat vas deferens.
Topics: Adenosine; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Bradykinin; Carbachol; Dos | 1996 |
Which type of 5-hydroxytryptamine receptor mediates relaxation of the longitudinal muscle of guinea pig proximal colon in vitro?
Topics: Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indoles; Ketanse | 1996 |
Ondansetron facilitates neuromuscular transmission in the guinea-pig ileum.
Topics: 5-Methoxytryptamine; Animals; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles | 1997 |
5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction.
Topics: 5-Methoxytryptamine; Animals; Female; Gastrointestinal Motility; Ileum; In Vitro Techniques; Ketanse | 1997 |
Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery.
Topics: Adolescent; Adult; Female; Humans; Ketanserin; Methiothepin; Muscle Contraction; Muscle, Smooth; Pre | 1999 |
Pinacidil suppression on 5-HT3 receptor-mediated contraction of guinea pig ileum in vitro.
Topics: Animals; Carbachol; Guinea Pigs; Ileum; Male; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; | 1998 |
Tetraethylammonium and 4-aminopyridine enhancement of 5-HT3 receptor-mediated contraction of guinea pig ileum in vitro.
Topics: 4-Aminopyridine; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Muscle, | 1998 |
Serotonin induces four pharmacologically separable contractile responses in the pharynx of the leech Hirudo medicinalis.
Topics: 5-Methoxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Dose-Response Re | 1999 |
Pharmacological profile of YM-31636, a novel 5-HT3 receptor agonist, in vitro.
Topics: Acetylcholine; Action Potentials; Animals; Anthraquinones; Atrial Function; Biguanides; Binding, Com | 2000 |
Potent antagonism of 5-HT(3) and 5-HT(6) receptors by olanzapine.
Topics: Animals; Benzodiazepines; Binding, Competitive; Clozapine; Dibenzothiazepines; Dose-Response Relatio | 2001 |
Intrathecal administration of 5-HT(3) receptor agonist modulates jaw muscle activity evoked by injection of mustard oil into the temporomandibular joint in the rat.
Topics: Afferent Pathways; Animals; Dose-Response Relationship, Drug; Drug Interactions; Efferent Pathways; | 2002 |
Ascending contraction mediated by 5-hydroxytryptamine3 receptors in canine small intestine.
Topics: Animals; Atropine; Dogs; Female; Hexamethonium; Hexamethonium Compounds; Intestine, Small; Male; Mus | 1992 |
Rabbit isolated renal artery contractions by some tryptamine derivatives, including 2-methyl-5-HT, are mediated by a 5-HT1-like receptor.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; In Vitro Techniques; In | 1992 |
SDZ 205-557, a selective antagonist at 5-HT4 receptors in the isolated guinea pig ileum.
Topics: 4-Aminobenzoic Acid; Animals; Guinea Pigs; Ileum; In Vitro Techniques; Muscle Contraction; Muscle, S | 1991 |
Effect of 2-methyl-5-hydroxytryptamine on motility of the isolated guinea-pig colon.
Topics: Acetylcholine; Animals; Colon; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Indoles; | 1990 |
Canine, but not rat bladder contracts to serotonin via activation of 5HT2 receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Dogs; Dose-Response Relationship, Drug; Ergolines; | 1990 |
An examination of the 5-HT3 receptor mediating contraction and evoked [3H]-acetylcholine release in the guinea-pig ileum.
Topics: Acetylcholine; Animals; Guinea Pigs; Ileum; Imidazoles; In Vitro Techniques; Male; Muscle Contractio | 1990 |
LY277359 maleate: a potent and selective 5-HT3 receptor antagonist without gastroprokinetic activity.
Topics: Animals; Benzofurans; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bridged-Ri | 1990 |