2-methoxyestrone has been researched along with Inflammation* in 1 studies
1 other study(ies) available for 2-methoxyestrone and Inflammation
| Article | Year |
|---|---|
Opposite estrogen effects of estrone and 2-hydroxyestrone on MCF-7 sensitivity to the cytotoxic action of cell growth, oxidative stress and inflammation activity.
There are many kinds of estrogens, and endogenous estrogens produce a variety of estrogen metabolites with similar structure but with different physiological effects after metabolism in vivo. Studies have shown that estrone (E1) widely occurs in the environment and animal-derived food. Because of its estrogen effect, E1 can have adverse effects on the human body as an endocrine disruptor. In this study, we found that E1 and 2-hydroxyestrone (2-OH-E1), the hydroxylation metabolite of estrogen, have opposite proliferative effects on breast cancer cells (MCF-7) through cell proliferation experiments and comparison of their effects by molecular docking and detection of ROS, Ca Topics: Cell Proliferation; Endocrine Disruptors; Estradiol; Estrogens; Estrone; Female; Humans; Hydroxyestrones; Hydroxylation; Inflammation; MCF-7 Cells; Molecular Docking Simulation; Oxidative Stress; Toxicity Tests | 2021 |