Page last updated: 2024-08-24

2-methoxyestradiol and Prostatic Neoplasms

2-methoxyestradiol has been researched along with Prostatic Neoplasms in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (2.44)	18.2507
2000's	26 (63.41)	29.6817
2010's	13 (31.71)	24.3611
2020's	1 (2.44)	2.80

Authors

Authors	Studies
Potter, BV; Thomas, MP	1
Varisli, L	1
Bedolla, R; Chiang, HC; Ghosh, R; Horning, A; Huang, TH; Kumar, AP; Li, R; Olumi, AF; Reddick, R; Yun, H	1
Hersi, F; Noreddin, AM; Nunes, ACF; Omar, HA; Tolba, MF	1
Ehteda, A; Galettis, P; Morris, DL; Pillai, K	1
Chang, I; Chiyomaru, T; Dahiya, R; Deng, G; Fukuhara, S; Majid, S; Saini, S; Shahryari, V; Tanaka, Y; Yamamura, S; Zaman, MS	1
Song, L; Wang, G; Wang, H; Xing, N	1
Song, L; Wang, H; Wang, J; Xing, N; Xu, Z; Yang, F	1
Song, LM; Wang, GD; Wang, HP; Xing, NZ	1
Cardenas, H; Díaz, P; Orihuela, PA	1
de las Pozas, A; Gomez, LA; Perez-Stable, C; Reiner, T	1
Alworth, WL; Chan, DC; Ganapathy, M; Ghosh, R; Kumar, AP	1
Bedolla, R; Ganapathy, M; Ghosh, R; Jianping, X; Kumar, AP; Olumi, AF; Schoolfield, J; Troyer, DA; Yeh, IT; Zhang, X	1
Mueck, AO; Seeger, H	1
Arnott, J; Hahn, NM; Hammers, H; Harrison, MR; Kim, K; Liu, G; Oh, WK; Perlman, S; Pili, R; Sidor, C; Sweeney, C; Wilding, G	1
de las Pozas, A; Parrondo, R; Perez-Stable, C; Rai, P; Reiner, T	1
Brautigan, DL; Larner, JM; Parsons, SJ; Sarkar, S	1
Blaukat, A; Bu, S; Fu, X; Heldin, NE; Landström, M	1
Figg, WD; Lakhani, NJ; Sarkar, MA; Venitz, J	1
Comninos, A; Day, JM; Leese, MP; Newman, SP; Potter, BV; Purohit, A; Reed, MJ; Solomon, C	1
Ishida, E; Kishi, M; Konishi, N; Nakamura, M; Shimada, K	1
Lippert, TH; Mueck, AO; Seeger, H	1
Ishida, E; Kishi, M; Konishi, N; Matsuyoshi, S; Nakamura, M; Shimada, K	1
Bergström, M; Davoodpour, P; Landström, M	1
Davoodpour, P; Landström, M	1
Armstrong, V; Fife, K; Horvath, D; Kolesar, J; Liu, G; Sidor, C; Staab, MJ; Sweeney, C; Treston, A; Wilding, G; Yiannoutsos, C	1
Basilion, JP; Fukuhara, H; Sato, F	1
Perez-Stable, C	1
Arevalo, N; Garcia, GE; Kraft, SL; Kumar, AP; Lucia, MS; Slaga, TJ; Strange, R; Wisniewski, HG	1
Banerjee, S; Banerjee, SK; Dhar, G; Ray, G; Saxena, NK; Sengupta, K; Van Veldhuizen, PJ	1
Adlouni, A; Bennani, H; Charrouf, Z; Drissi, A; Fiet, J; Giton, F	1
Adlouni, A; Bennani, H; Drissi, A; Fiet, J; Giton, F; Kheuang, L	1
Dahut, WL; Figg, WD; Lakhani, NJ; Sparreboom, A; Veenstra, TD; Venitz, J; Xu, X	1
Burnstein, K; de Las Pozas, A; Gomez, LA; Perez-Stable, C; Reiner, T	1
Davoodpour, P; Landström, M; Welsh, M	1
Amorino, GP; Casarez, EV; Conaway, MR; Dunlap-Brown, ME	1
Banerjee, S; Banerjee, SK; Dhar, A; Dhar, G; Kambhampati, S; Ray, G; Van Veldhuizen, PJ	1
Amir, S; Mabjeesh, NJ; Matzkin, H; Shefler, A	1
Anderson, C; D'Ippolito, G; Herron, A; Howard, GA; Perez-Stable, CM; Qadan, LR; Roos, BA	1
Garcia, GE; Kumar, AP; Slaga, TJ	1
Khan, MS; Nakhla, AM; Rosner, W	1

Reviews

3 review(s) available for 2-methoxyestradiol and Prostatic Neoplasms

Article	Year
2-Methoxyestradiol--biology and mechanism of action. Steroids, 2010, Volume: 75, Issue:10 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Proliferation; Estradiol; Female; Humans; Male; Models, Biological; Prostatic Neoplasms	2010
2-Methoxyestradiol, a promising anticancer agent. Pharmacotherapy, 2003, Volume: 23, Issue:2 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Breast Neoplasms; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Double-Blind Method; Estradiol; Female; Humans; Male; Prostatic Neoplasms; Randomized Controlled Trials as Topic	2003
[Estrogen-dependent neoplasia - what is the significance of estradiol metabolites]. Zentralblatt fur Gynakologie, 2003, Volume: 125, Issue:11 Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Breast Neoplasms; Estradiol; Estrogens, Catechol; Female; Humans; Hydroxyestrones; Male; Neovascularization, Pathologic; Neovascularization, Physiologic; Postmenopause; Prostatic Neoplasms	2003

Trials

3 trial(s) available for 2-methoxyestradiol and Prostatic Neoplasms

Article	Year
A phase II study of 2-methoxyestradiol (2ME2) NanoCrystal® dispersion (NCD) in patients with taxane-refractory, metastatic castrate-resistant prostate cancer (CRPC). Investigational new drugs, 2011, Volume: 29, Issue:6 Topics: 2-Methoxyestradiol; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Disease-Free Survival; Estradiol; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Nanoparticles; Neoplasm Metastasis; Positron-Emission Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Treatment Outcome	2011
A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Sep-15, Volume: 11, Issue:18 Topics: 2-Methoxyestradiol; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Area Under Curve; Capsules; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Neoplasm; Estradiol; Female; Fibroblast Growth Factor 2; Humans; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A	2005
Characterization of in vitro and in vivo metabolic pathways of the investigational anticancer agent, 2-methoxyestradiol. Journal of pharmaceutical sciences, 2007, Volume: 96, Issue:7 Topics: 2-Methoxyestradiol; Administration, Oral; Antineoplastic Agents; Biotransformation; Chromatography, High Pressure Liquid; Drugs, Investigational; Estradiol; Female; Glucuronic Acid; Humans; In Vitro Techniques; Male; Microsomes, Liver; Molecular Structure; Ovarian Neoplasms; Oxidation-Reduction; Prostatic Neoplasms; Tandem Mass Spectrometry	2007

Other Studies

35 other study(ies) available for 2-methoxyestradiol and Prostatic Neoplasms

Article	Year
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health. Journal of medicinal chemistry, 2015, Oct-08, Volume: 58, Issue:19 Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Discovery; Endometriosis; Estrone; Female; Humans; Male; Molecular Targeted Therapy; Prostatic Neoplasms; Steryl-Sulfatase; Sulfonic Acids; Tubulin Modulators	2015
Decreased Expression of HN1 Sensitizes Prostate Cancer Cells to Apoptosis Induced by Docetaxel and 2-Methoxyestradiol. Annals of clinical and laboratory science, 2022, Volume: 52, Issue:2 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Cell Cycle Proteins; Cell Line, Tumor; Cyclin B1; Docetaxel; Humans; Male; Mammals; Prostatic Neoplasms	2022
BRCA1 Interacting Protein COBRA1 Facilitates Adaptation to Castrate-Resistant Growth Conditions. International journal of molecular sciences, 2018, Jul-20, Volume: 19, Issue:7 Topics: 2-Methoxyestradiol; Animals; BRCA1 Protein; Cell Proliferation; Cell Survival; DNA Methylation; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Nuclear Proteins; Prostatic Neoplasms; Protein Binding; Receptors, Androgen; RNA-Binding Proteins; Transcription Factors	2018
The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers. Molecular and cellular endocrinology, 2019, 05-15, Volume: 488 Topics: 2-Methoxyestradiol; Aromatase; Breast Neoplasms; Catechol O-Methyltransferase; Catechols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Docetaxel; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Hormones; Humans; Male; Nitriles; Phosphorylation; Prostatic Neoplasms; Receptors, Estrogen; RNA, Small Interfering; Transcription Factor RelA	2019
Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice. BMC cancer, 2013, Feb-23, Volume: 13 Topics: 2-Methoxyestradiol; Albendazole; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colchicine; Colorectal Neoplasms; Cytotoxins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostatic Neoplasms; Tubulin Modulators	2013
Hrk mediates 2-methoxyestradiol-induced mitochondrial apoptotic signaling in prostate cancer cells. Molecular cancer therapeutics, 2013, Volume: 12, Issue:6 Topics: 2-Methoxyestradiol; Apoptosis; Apoptosis Regulatory Proteins; bcl-2 Homologous Antagonist-Killer Protein; Cell Line, Tumor; Estradiol; Estrogens; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; Male; MAP Kinase Kinase 4; Mitochondria; Prostatic Neoplasms; Signal Transduction	2013
Quercetin synergizes with 2-methoxyestradiol inhibiting cell growth and inducing apoptosis in human prostate cancer cells. Oncology reports, 2013, Volume: 30, Issue:1 Topics: 2-Methoxyestradiol; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Estradiol; Humans; Male; Prostatic Neoplasms; Quercetin; Tubulin Modulators	2013
Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PloS one, 2015, Volume: 10, Issue:5 Topics: 2-Methoxyestradiol; Animals; Cell Line, Tumor; Chromones; Estradiol; Flavones; Heterografts; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Prostatic Neoplasms; Xenograft Model Antitumor Assays	2015
[Effect of 2-methoxyestradiol combined with quercetin on prostate cancer in vitro]. Zhonghua yi xue za zhi, 2016, Jan-12, Volume: 96, Issue:2 Topics: 2-Methoxyestradiol; Androgens; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Estradiol; Humans; Male; Prostatic Neoplasms; Quercetin	2016
Red Maca (Lepidium meyenii) did not affect cell viability despite increased androgen receptor and prostate-specific antigen gene expression in the human prostate cancer cell line LNCaP. Andrologia, 2016, Volume: 48, Issue:8 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Survival; Drug Synergism; Estradiol; Gene Expression; Humans; Kallikreins; Lepidium; Male; Paclitaxel; Plant Extracts; Prostate-Specific Antigen; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Receptors, Androgen; RNA, Messenger	2016
Low dose combinations of 2-methoxyestradiol and docetaxel block prostate cancer cells in mitosis and increase apoptosis. Cancer letters, 2009, Apr-08, Volume: 276, Issue:1 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Cell Line, Tumor; Docetaxel; Estradiol; Flow Cytometry; Humans; Immunohistochemistry; Male; Mice; Mice, Transgenic; Mitosis; Prostatic Neoplasms; RNA, Small Interfering; Taxoids; Transfection; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays	2009
Combination of 2-methoxyestradiol (2-ME2) and eugenol for apoptosis induction synergistically in androgen independent prostate cancer cells. The Journal of steroid biochemistry and molecular biology, 2009, Volume: 113, Issue:1-2 Topics: 2-Methoxyestradiol; Androgens; Apoptosis; bcl-2-Associated X Protein; Cell Adhesion; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Shape; Cell Survival; Drug Screening Assays, Antitumor; Drug Synergism; Estradiol; Eugenol; Flow Cytometry; Humans; Male; Membrane Potential, Mitochondrial; Phosphoproteins; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt	2009
Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Mar-01, Volume: 15, Issue:5 Topics: 2-Methoxyestradiol; Adenocarcinoma; Animals; CASP8 and FADD-Like Apoptosis Regulating Protein; Chromatin Immunoprecipitation; Disease Models, Animal; Estradiol; Fas-Associated Death Domain Protein; Humans; Immunoblotting; Immunoenzyme Techniques; Immunoprecipitation; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Sp1 Transcription Factor; Sp3 Transcription Factor; Transfection; Tubulin Modulators; Tumor Cells, Cultured	2009
NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells. Molecular cancer, 2010, Jul-09, Volume: 9 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Base Sequence; Betulinic Acid; Blotting, Western; Cell Line, Tumor; DNA Primers; Docetaxel; Estradiol; Flow Cytometry; Humans; Immunohistochemistry; Male; Mitosis; NF-kappa B; Pentacyclic Triterpenes; Prostatic Neoplasms; Sesquiterpenes; Taxoids; Triterpenes	2010
Androgen receptor degradation by the E3 ligase CHIP modulates mitotic arrest in prostate cancer cells. Oncogene, 2014, Jan-02, Volume: 33, Issue:1 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Cell Line, Tumor; Drug Resistance, Neoplasm; Estradiol; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; M Phase Cell Cycle Checkpoints; Male; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Proteolysis; Proto-Oncogene Proteins c-mdm2; Receptors, Androgen; RNA, Small Interfering; Tubulin Modulators; Tumor Suppressor Protein p53; Ubiquitin-Protein Ligases	2014
Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. FEBS letters, 2002, Nov-06, Volume: 531, Issue:2 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Breast; Breast Neoplasms; Carcinoma; Caspases; Cell Division; Colonic Neoplasms; Endothelium; Estradiol; Female; Humans; Kinetics; Liver Neoplasms; Male; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Tumor Cells, Cultured	2002
The effects of 2-substituted oestrogen sulphamates on the growth of prostate and ovarian cancer cells. The Journal of steroid biochemistry and molecular biology, 2003, Volume: 84, Issue:2-3 Topics: 2-Methoxyestradiol; Apoptosis; Cell Division; Cell Separation; Estradiol; Estrone; Female; Flow Cytometry; G1 Phase; G2 Phase; Humans; Hydroxyestrones; Immunoblotting; Inhibitory Concentration 50; Male; Mitosis; Models, Chemical; Ovarian Neoplasms; Paclitaxel; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Time Factors; Tumor Cells, Cultured	2003
Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis. Carcinogenesis, 2003, Volume: 24, Issue:6 Topics: 2-Methoxyestradiol; Apoptosis; Dihydrotestosterone; Estradiol; Humans; JNK Mitogen-Activated Protein Kinases; Male; Mitogen-Activated Protein Kinases; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Transcription Factor AP-1; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2003
The molecular mechanism of sensitization to Fas-mediated apoptosis by 2-methoxyestradiol in PC3 prostate cancer cells. Molecular carcinogenesis, 2004, Volume: 39, Issue:1 Topics: 2-Methoxyestradiol; Apoptosis; Arabidopsis Proteins; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Chromones; Death Domain Receptor Signaling Adaptor Proteins; Drug Resistance, Neoplasm; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Inhibitors; Estradiol; fas Receptor; Fatty Acid Desaturases; Flavonoids; Genes, Dominant; Humans; I-kappa B Proteins; Intracellular Signaling Peptides and Proteins; Luciferases; Male; Mitogen-Activated Protein Kinases; Morpholines; NF-kappa B; NF-KappaB Inhibitor alpha; Nitriles; Organic Chemicals; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor; Signal Transduction; Sulfones; Tumor Cells, Cultured	2004
Effects of 2-methoxyestradiol on proliferation, apoptosis and PET-tracer uptake in human prostate cancer cell aggregates. Nuclear medicine and biology, 2004, Volume: 31, Issue:7 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Cell Aggregation; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Estradiol; Humans; Male; Neoplasm Staging; Positron-Emission Tomography; Prostatic Neoplasms; Radioisotopes; Radiopharmaceuticals; Reproducibility of Results; Sensitivity and Specificity	2004
2-Methoxyestradiol-induced apoptosis in prostate cancer cells requires Smad7. The Journal of biological chemistry, 2005, Apr-15, Volume: 280, Issue:15 Topics: 2-Methoxyestradiol; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; beta Catenin; Blotting, Western; Carrier Proteins; Cell Line, Tumor; Cell Nucleus; Cytoskeletal Proteins; DNA-Binding Proteins; Estradiol; Humans; Male; Membrane Proteins; Neovascularization, Pathologic; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins; RNA; RNA, Small Interfering; Signal Transduction; Smad7 Protein; Time; Time Factors; Trans-Activators; Transforming Growth Factor beta	2005
Effects of hormone deprivation and 2-methoxyestradiol combination therapy on hormone-dependent prostate cancer in vivo. Neoplasia (New York, N.Y.), 2005, Volume: 7, Issue:9 Topics: 2-Methoxyestradiol; Androgens; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Combined Modality Therapy; Estradiol; Humans; Male; Mice; Neoplasms, Hormone-Dependent; Orchiectomy; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Xenograft Model Antitumor Assays	2005
2-Methoxyestradiol and paclitaxel have similar effects on the cell cycle and induction of apoptosis in prostate cancer cells. Cancer letters, 2006, Jan-08, Volume: 231, Issue:1 Topics: 2-Methoxyestradiol; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Cycle; Cyclin B1; Cyclin-Dependent Kinases; Estradiol; Humans; Male; Paclitaxel; Prostatic Neoplasms; Tubulin Modulators; Tumor Cells, Cultured	2006
2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-01, Volume: 12, Issue:3 Pt 1 Topics: 2-Methoxyestradiol; Adenocarcinoma; Animals; Cell Adhesion Molecules; Cell Line, Tumor; Diet; Disease Models, Animal; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms	2006
Modulation of cell-cycle regulatory signaling network by 2-methoxyestradiol in prostate cancer cells is mediated through multiple signal transduction pathways. Biochemistry, 2006, Mar-21, Volume: 45, Issue:11 Topics: 2-Methoxyestradiol; Apoptosis; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin B; Cyclin B1; Cytoplasm; Estradiol; Extracellular Signal-Regulated MAP Kinases; G2 Phase; Humans; JNK Mitogen-Activated Protein Kinases; Male; Models, Biological; Nuclear Proteins; Phosphorylation; Prostatic Neoplasms; Protein-Tyrosine Kinases; S Phase; Signal Transduction; Tubulin Modulators; Tumor Cells, Cultured; Up-Regulation	2006
Tocopherols and saponins derived from Argania spinosa exert, an antiproliferative effect on human prostate cancer. Cancer investigation, 2006, Volume: 24, Issue:6 Topics: 2-Methoxyestradiol; Antioxidants; Cell Proliferation; Estradiol; Humans; Male; Neoplasms, Hormone-Dependent; Plant Oils; Prostatic Neoplasms; Saponins; Sapotaceae; Thymidine; Tocopherols; Trees; Tubulin Modulators; Tumor Cells, Cultured	2006
Antiproliferative effect of polyphenols and sterols of virgin argan oil on human prostate cancer cell lines. Cancer detection and prevention, 2007, Volume: 31, Issue:1 Topics: 2-Methoxyestradiol; Antioxidants; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Estradiol; Flavonoids; Fruit; Humans; Inhibitory Concentration 50; Male; Mitosis; Phenols; Plant Extracts; Plant Oils; Polyphenols; Prostatic Neoplasms; Sapotaceae; Sterols; Time Factors; Tubulin Modulators	2007
Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy. Molecular cancer therapeutics, 2007, Volume: 6, Issue:5 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cyclin B; Cyclin B1; Docetaxel; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Male; Mitosis; Neoplasms; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Taxoids	2007
Reduced tumor growth in vivo and increased c-Abl activity in PC3 prostate cancer cells overexpressing the Shb adapter protein. BMC cancer, 2007, Aug-15, Volume: 7 Topics: 2-Methoxyestradiol; Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Blotting, Western; Cell Proliferation; Enzyme Inhibitors; Estradiol; Female; Humans; Male; Mice; Mice, Nude; p38 Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-abl; Signal Transduction; Transfection; Tubulin Modulators; Tumor Cells, Cultured; Up-Regulation	2007
Radiosensitization and modulation of p44/42 mitogen-activated protein kinase by 2-Methoxyestradiol in prostate cancer models. Cancer research, 2007, Sep-01, Volume: 67, Issue:17 Topics: 2-Methoxyestradiol; Animals; Carcinoma; Estradiol; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Prostatic Neoplasms; Radiation-Sensitizing Agents; Subcutaneous Tissue; Transplantation, Heterotopic; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2007
2-Methoxyestradiol modulates beta-catenin in prostate cancer cells: a possible mediator of 2-methoxyestradiol-induced inhibition of cell growth. International journal of cancer, 2008, Feb-01, Volume: 122, Issue:3 Topics: 2-Methoxyestradiol; Apoptosis; beta Catenin; Blotting, Western; Cell Nucleus; Cell Proliferation; Cyclin D; Cyclins; Estradiol; Humans; Male; MAP Kinase Kinase 1; Mitogen-Activated Protein Kinase 1; Neoplasms, Hormone-Dependent; Phosphorylation; Prostatic Neoplasms; Protein Transport; Signal Transduction; Subcellular Fractions; TCF Transcription Factors; Tubulin Modulators; Tumor Cells, Cultured	2008
Potentiation of 2-methoxyestradiol-induced cytotoxicity by blocking endothelin A receptor in prostate cancer cells. The Prostate, 2008, May-01, Volume: 68, Issue:6 Topics: 2-Methoxyestradiol; Adenocarcinoma; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Coculture Techniques; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Synergism; Endothelin Receptor Antagonists; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Osteoblasts; Peptides, Cyclic; Prostate-Specific Antigen; Prostatic Neoplasms; RNA, Messenger	2008
2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer. Biochemical and biophysical research communications, 2001, Aug-03, Volume: 285, Issue:5 Topics: 2-Methoxyestradiol; Administration, Oral; Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Division; Cell Nucleus; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Drug Implants; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Flow Cytometry; G2 Phase; Humans; Male; Mice; Mice, Transgenic; Mitosis; Prostatic Neoplasms; Tumor Cells, Cultured	2001
2-methoxyestradiol blocks cell-cycle progression at G(2)/M phase and inhibits growth of human prostate cancer cells. Molecular carcinogenesis, 2001, Volume: 31, Issue:3 Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspases; CDC2 Protein Kinase; Cell Cycle; Cell Cycle Proteins; Cell Division; Cell Survival; Dose-Response Relationship, Drug; Estradiol; Flow Cytometry; G1 Phase; G2 Phase; Genes, p53; Humans; In Situ Nick-End Labeling; Male; Mitosis; Mutation; Nuclear Proteins; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; Protein-Tyrosine Kinases; Proto-Oncogene Proteins p21(ras); Receptors, Estrogen; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2001
Biologically active steroids activate receptor-bound human sex hormone-binding globulin to cause LNCaP cells to accumulate adenosine 3',5'-monophosphate. The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:2 Topics: 2-Methoxyestradiol; Adenylyl Cyclases; Cell Line; Cell Membrane; Cyclic AMP; Dihydrotestosterone; Estradiol; Humans; Kinetics; Male; Prostatic Neoplasms; Receptors, Cell Surface; Sex Hormone-Binding Globulin; Tumor Cells, Cultured	1990