2-methoxyestradiol has been researched along with Neoplasms in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (2.94) | 18.2507 |
| 2000's | 18 (52.94) | 29.6817 |
| 2010's | 14 (41.18) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| Choi, HK; Lee, K; Xia, Y | 1 |
| Kim, HS; Kim, SJ; Seo, YR | 1 |
| Ba, M; Duan, Y | 1 |
| Gao, S; Li, P; Lu, X; Nie, R; Shi, X; Sun, S; Wang, C; Wang, Z; Wu, D; Xia, L; Xu, F; Yao, H; Zhang, Z | 1 |
| Hansen, TV; Labba, NA; Paulsen, RE; Solum, EJ; Sørvik, IB | 1 |
| Chen, C; Hou, L; Li, H; Shi, J; Shi, X; Wang, L; Zhang, C; Zhang, H; Zhang, M; Zhang, Z | 1 |
| Diaz, P; Orihuela, PA; Parada-Bustamante, A; Reuquen, P; Rincion-Rodriguez, R; Valencia, C | 1 |
| Akselsen, ØW; Hansen, TV; Solum, EJ; Vik, A | 1 |
| Gorska, M; Kuban-Jankowska, A; Slawek, J; Wozniak, M | 1 |
| Menon, D; Nair, SV; Paul-Prasanth, B; Pillai, GJ | 1 |
| Alberti, DB; Arnott, J; Holen, KD; Liu, G; Quon, C; Sidor, C; Tevaarwerk, AJ; Wilding, G | 1 |
| Camidge, DR; Diab, S; Eckhardt, SG; Gore, L; Gustafson, D; Leong, S; Lewis, K; Messersmith, WA; Nallapareddy, S; Sidor, C; Treston, AM; Zhou, Q | 1 |
| Gerk, PM; Verenich, S | 1 |
| Cao, X; Guo, R; Shen, M; Shi, X; Wang, Y | 1 |
| Czyz, M; Duechler, M; Wilczynski, J | 1 |
| Alami, M; Brion, JD; Peyrat, JF | 1 |
| Lippert, TH; Mueck, AO; Seeger, H | 1 |
| Baranczyk-Kuzma, A; Czeczot, H; Golab, J; Grzela, T; Jakobisiak, M; Jalili, A; Kaminski, R; Kopec', M; Kozar, K; Makowski, M; Mroz, P; Nowis, D; Skrzycki, M; Wilczynski, GM | 1 |
| Figg, WD; Lakhani, NJ; Sparreboom, A; Venitz, J | 1 |
| Mooberry, SL | 1 |
| Bedogni, B; Borrello, S; Colavitti, R; Ferraro, D; Fusco, S; Galeotti, T; Pani, G | 1 |
| Arlen, PM; Dahut, WL; Figg, WD; Gulley, JL; Kohn, EC; Kotz, H; Lakhani, NJ; McNally, D; Nguyen, D; Parr, A; Sparreboom, A; Steinberg, SM; Venitz, J; Yang, SX | 1 |
| Neuhaus, P; Schumacher, G | 2 |
| Burnstein, K; de Las Pozas, A; Gomez, LA; Perez-Stable, C; Reiner, T | 1 |
| Altmann, E; Anderson, RL; Hughes, RA; Schuliga, M; Stewart, AG; Sutherland, TE; Ziogas, J | 1 |
| Sato, Y | 1 |
| Green, SJ; Gubish, ER; Lavallee, TM; Pribluda, VS; Swartz, GM; Treston, A | 1 |
| Bergen, M; Eckhardt, SG; Hidalgo, M; Holden, SN; Pierson, AS | 1 |
| Das, U | 1 |
20 review(s) available for 2-methoxyestradiol and Neoplasms
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
Recent advances in hypoxia-inducible factor (HIF)-1 inhibitors.
Topics: Animals; Antineoplastic Agents; Drug Discovery; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Models, Molecular; Neoplasms; Neovascularization, Pathologic; Small Molecule Libraries | 2012 |
Understanding of ROS-Inducing Strategy in Anticancer Therapy.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Homeostasis; Humans; Neoplasms; Oxidants; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species | 2019 |
Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease.
Topics: 2-Methoxyestradiol; Animals; Apoptosis; Catechol O-Methyltransferase; Drug Carriers; Estradiol; Humans; Microtubules; Neoplasms; Reactive Oxygen Species; Receptors, Estrogen; Reproduction | 2015 |
Synthesis and Pharmacological Effects of the Anti-Cancer Agent 2-Methoxyestradiol.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Cell Line, Tumor; Clinical Trials as Topic; Estradiol; Humans; Neoplasms; Receptors, Estrogen; Treatment Outcome | 2015 |
New Insight into 2-Methoxyestradiol- a Possible Physiological Link between Neurodegeneration and Cancer Cell Death.
Topics: 2-Methoxyestradiol; Cell Death; Estradiol; Humans; Neoplasms; Neurodegenerative Diseases; Oxidative Stress | 2016 |
Therapeutic promises of 2-methoxyestradiol and its drug disposition challenges.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Screening Assays, Antitumor; Drug Stability; Estradiol; Humans; Neoplasms | 2010 |
Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Clinical Trials as Topic; Estradiol; Humans; Hypoxia-Inducible Factor 1; Indazoles; Mice; Neoplasms; NF-kappa B; Topotecan; Transcription Factors; Tumor Cells, Cultured | 2011 |
Synthetic 2-methoxyestradiol derivatives: structure-activity relationships.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Clinical Trials as Topic; Estradiol; Humans; Neoplasms; Reactive Oxygen Species; Structure-Activity Relationship | 2012 |
Estradiol metabolism and malignant disease.
Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Estradiol; Estriol; Estrogens, Catechol; Female; Humans; Hydroxyestrones; Molecular Structure; Neoplasms | 2002 |
Pharmacogenetics of estrogen metabolism and transport in relation to cancer.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Diethylstilbestrol; Estradiol; Estrogens; Female; Genetic Predisposition to Disease; Humans; Male; Neoplasms | 2003 |
Mechanism of action of 2-methoxyestradiol: new developments.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; DNA-Binding Proteins; Estradiol; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Microtubules; Neoplasms; Nuclear Proteins; Reactive Oxygen Species; Receptors, Estrogen; Transcription Factors | 2003 |
Mitochondrial superoxide dismutase: a promising target for new anticancer therapies.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Division; Estradiol; Humans; Mitochondria; Models, Biological; Neoplasms; Superoxide Dismutase; Tumor Suppressor Protein p53 | 2004 |
[2-Methoxyestradiol -- a new compound for cancer treatment].
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Disease Models, Animal; Estradiol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Neovascularization, Pathologic; Spindle Apparatus; Treatment Outcome; Tubulin Modulators | 2006 |
2-Methoxyestradiol--a unique blend of activities generating a new class of anti-tumour/anti-inflammatory agents.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Apoptosis; Cell Proliferation; Drug Design; Estradiol; Humans; Neoplasms; Quantitative Structure-Activity Relationship | 2007 |
[Biosynthesis and microbial transformation of griseofulvin and carcinogenesis and prevention of cancer by estrogens].
Topics: 2-Methoxyestradiol; Animals; Cricetinae; Estradiol; Estrogens; Female; Griseofulvin; Humans; Microtubule Proteins; Microtubules; Neoplasms; Penicillium; Streptomyces | 1995 |
2-Methoxyestradiol: an endogenous antiangiogenic and antiproliferative drug candidate.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Cell Division; Cell Line; Estradiol; Humans; Neoplasm Metastasis; Neoplasms; Neoplasms, Experimental; Neovascularization, Pathologic; Neovascularization, Physiologic; Tumor Cells, Cultured | 2000 |
The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Estradiol; Humans; Neoplasms; Neovascularization, Pathologic | 2001 |
Therapeutic angiogenesis inhibitors in the treatment of cancer.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antineoplastic Agents; Collagen; Endostatins; Endothelial Growth Factors; Enzyme Inhibitors; Estradiol; Humans; Hydroxamic Acids; Lymphokines; Matrix Metalloproteinase Inhibitors; Neoplasms; Organic Chemicals; Peptide Fragments; Protein-Tyrosine Kinases; Thalidomide; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2001 |
A radical approach to cancer.
Topics: 2-Methoxyestradiol; Anaerobiosis; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Cell Division; Enzyme Inhibitors; Estradiol; Fatty Acids, Unsaturated; Free Radicals; Humans; Lipid Peroxidation; Neoplasm Proteins; Neoplasms; Neovascularization, Pathologic; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Telomere; Thalidomide; Vitamin E | 2002 |
3 trial(s) available for 2-methoxyestradiol and Neoplasms
| Article | Year |
|---|---|
Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies.
Topics: 2-Methoxyestradiol; Aged; Aged, 80 and over; Estradiol; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Nanoparticles; Neoplasms | 2009 |
A phase I dose-escalation, safety and pharmacokinetic study of the 2-methoxyestradiol analog ENMD-1198 administered orally to patients with advanced cancer.
Topics: 2-Methoxyestradiol; Administration, Oral; Adult; Aged; Animals; Antineoplastic Agents; Demography; Dogs; Dose-Response Relationship, Drug; Estradiol; Estrenes; Female; Humans; Male; Middle Aged; Neoplasms; Rats; Species Specificity | 2011 |
Phase I clinical trial of oral 2-methoxyestradiol, an antiangiogenic and apoptotic agent, in patients with solid tumors.
Topics: 2-Methoxyestradiol; Administration, Oral; Adult; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Capillaries; Cell Proliferation; Estradiol; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Tomography, X-Ray Computed | 2006 |
11 other study(ies) available for 2-methoxyestradiol and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Advance of 2-methoxyestradiol as a promising anticancer agent for cancer therapy.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Cell Proliferation; Humans; Neoplasms | 2020 |
Design, synthesis and antiproliferative effect of 17β-amide derivatives of 2-methoxyestradiol and their studies on pharmacokinetics.
Topics: 2-Methoxyestradiol; Animals; Cell Proliferation; Drug Design; Estradiol; Humans; MCF-7 Cells; Mice; Neoplasms | 2017 |
Differential effects of some novel synthetic oestrogen analogs on oxidative PC12 cell death caused by serum deprivation.
Topics: 2-Methoxyestradiol; Animals; Apoptosis; Estradiol; Estradiol Congeners; Glutamate-Cysteine Ligase; Glutathione; Neoplasms; NF-E2-Related Factor 2; Oxidative Stress; PC12 Cells; Rats; Signal Transduction | 2018 |
Single-walled carbon nanotubes mediated neovascularity targeted antitumor drug delivery system.
Topics: 2-Methoxyestradiol; Animals; Cell Line, Tumor; Drug Delivery Systems; Estradiol; Female; Humans; MCF-7 Cells; Mice; Mice, Inbred BALB C; Nanotubes, Carbon; Neoplasms; Neovascularization, Pathologic; Oligopeptides; Tissue Distribution; Tubulin Modulators | 2013 |
Influence of surface passivation of 2-Methoxyestradiol loaded PLGA nanoparticles on cellular interactions, pharmacokinetics and tumour accumulation.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Caseins; Drug Carriers; Drug Delivery Systems; Estradiol; Female; Human Umbilical Vein Endothelial Cells; Humans; Lactic Acid; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Neoplasms; Particle Size; Polyethylene Glycols; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Protein Binding; Rats; Rats, Sprague-Dawley; Surface Properties | 2017 |
Encapsulation of 2-methoxyestradiol within multifunctional poly(amidoamine) dendrimers for targeted cancer therapy.
Topics: 2-Methoxyestradiol; Cell Line, Tumor; Cell Survival; Dendrimers; Estradiol; Fluorescein-5-isothiocyanate; Folic Acid; Humans; Kinetics; Magnetic Resonance Spectroscopy; Microscopy, Confocal; Neoplasms; Organ Specificity; Spectrophotometry, Ultraviolet; Static Electricity | 2011 |
Antitumor effects of photodynamic therapy are potentiated by 2-methoxyestradiol. A superoxide dismutase inhibitor.
Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Dihematoporphyrin Ether; Drug Therapy, Combination; Enzyme Inhibitors; Estradiol; Humans; Immunohistochemistry; Mice; Mice, Inbred Strains; Neoplasms; Photochemotherapy; Superoxide Dismutase; Survival Rate; Tumor Cells, Cultured | 2003 |
Introgen obtains key patent obtained for p53-targeted chemotherapy.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Clinical Trials, Phase III as Topic; Estradiol; Genes, p53; Humans; Neoplasms; Patents as Topic; United States | 2002 |
The new cancer blockers.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bevacizumab; Estradiol; Humans; Neoplasms; Neovascularization, Pathologic; Thalidomide; Tissue Extracts | 2004 |
Increased expression of cyclin B1 sensitizes prostate cancer cells to apoptosis induced by chemotherapy.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Cell Differentiation; Cell Line, Tumor; Cyclin B; Cyclin B1; Docetaxel; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Male; Mitosis; Neoplasms; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; RNA, Small Interfering; Taxoids | 2007 |