2-methoxyestradiol has been researched along with Kahler Disease in 24 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 23 (95.83) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hou, J; Jiang, H | 1 |
| Gu, JL; Huang, BH; Li, J; Liu, JR; Su, C; Zheng, D; Zhou, ZH | 1 |
| Anderson, KC; Cole, CE; Ryoo, JJ | 1 |
| Anderson, KC; Catley, L; Chauhan, D; Gupta, D; Hideshima, T; Leblanc, R; Li, G; Munshi, N; Podar, K; Richardson, P; Sattler, M; Schlossman, RL; Weller, E | 1 |
| Dingli, D; Rajkumar, SV; Russell, SJ; Timm, M; Witzig, TE | 1 |
| Anderson, KC; Auclair, D; Chauhan, D; Chen, LB; Hideshima, T; Kim, RS; Li, C; Li, G; Mitsiades, C; Mitsiades, N; Munshi, N; Podar, K; Richardson, P; Wong, W | 1 |
| Anderson, KC; Hayashi, T; Hideshima, T | 1 |
| Anderson, KC; Chauhan, D; Hideshima, T; Li, G; Mitsiades, C; Mitsiades, N; Munshi, N; Podar, K; Sattler, M | 1 |
| Mooberry, SL | 1 |
| Anderson, KC; Auclair, D; Chauhan, D; Chen, LB; Hideshima, T; Li, G; Mitsiades, C; Mitsiades, N; Munshi, N; Podar, K; Saxena, S | 1 |
| Bertola, A; Boccadoro, M; Bruno, B; Giaccone, L; Massaia, M; Palumbo, A; Rotta, M | 1 |
| Gao, WR; Hou, J | 2 |
| Chen, QB; Gao, WR; Hou, J; Xiong, H | 1 |
| Anderson, KC; Catley, L; Chauhan, D; Tai, YT | 1 |
| Gao, W; Hou, J; Jiang, H; Xiong, H | 1 |
| Gao, WR; Hou, J; Jiang, H; Xiong, H | 1 |
| Gao, WR; Hou, J; Xiong, H | 1 |
| Farrar, WL; Hurt, EM; Peng, B; Thomas, SB | 1 |
| Hou, J; Jiang, H; Zhou, X | 1 |
| Hou, J; Jiang, H; Zhou, F; Zhou, X | 1 |
| Anderson, KC; Dispenzieri, A; Gertz, MA; Greipp, PR; Lacy, MQ; Rajkumar, SV; Richardson, PG; Schlossman, R; Sidor, CF; Witzig, TE | 1 |
| Gao, W; Hou, J; Jiang, H; Sze, DM; Xiong, H | 1 |
| Fu, W; Hou, J; Jiang, H; Wang, D; Yuan, Z; Zhou, L | 1 |
5 review(s) available for 2-methoxyestradiol and Kahler Disease
| Article | Year |
|---|---|
Novel therapies for multiple myeloma.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Cysteine Endopeptidases; Enzyme Inhibitors; Estradiol; Humans; Multienzyme Complexes; Multiple Myeloma; Oxides; Proteasome Endopeptidase Complex; Thalidomide; Tissue Extracts | 2002 |
Novel therapies for multiple myeloma.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Bone Marrow Cells; Enzyme Inhibitors; Estradiol; Heterocyclic Compounds, 3-Ring; Humans; Multiple Myeloma; NF-kappa B; Oxides; Phthalazines; Protease Inhibitors; Protein-Tyrosine Kinases; Pyridines; Thalidomide | 2003 |
New insights into 2-methoxyestradiol, a promising antiangiogenic and antitumor agent.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Bone Marrow Neoplasms; Estradiol; Humans; Multiple Myeloma; Neovascularization, Pathologic | 2003 |
New drugs for treatment of multiple myeloma.
Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Clinical Trials as Topic; Diphosphonates; Enzyme Inhibitors; Estradiol; Humans; Multiple Myeloma; Neovascularization, Pathologic; Oxides; Receptors, Vascular Endothelial Growth Factor; Signal Transduction; Thalidomide | 2004 |
Perspectives for combination therapy to overcome drug-resistant multiple myeloma.
Topics: 2-Methoxyestradiol; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Clinical Trials as Topic; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Histone Deacetylase Inhibitors; Humans; Multiple Myeloma; Oxides; p38 Mitogen-Activated Protein Kinases; Proteasome Inhibitors; Receptor Protein-Tyrosine Kinases; Thalidomide | 2005 |
1 trial(s) available for 2-methoxyestradiol and Kahler Disease
| Article | Year |
|---|---|
Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma.
Topics: 2-Methoxyestradiol; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Disease Progression; Disease-Free Survival; Estradiol; Female; Humans; Male; Middle Aged; Multiple Myeloma; Recurrence; Time Factors; Treatment Outcome; Tubulin Modulators | 2007 |
18 other study(ies) available for 2-methoxyestradiol and Kahler Disease
| Article | Year |
|---|---|
[Effect of low-dose 2-methoxyestradiol on the expressions of two isoforms of PRDM1 gene in myeloma].
Topics: 2-Methoxyestradiol; Cell Differentiation; Cell Line, Tumor; Estradiol; Humans; Multiple Myeloma; Positive Regulatory Domain I-Binding Factor 1; Repressor Proteins | 2009 |
Differentiation induction enhances bortezomib efficacy and overcomes drug resistance in multiple myeloma.
Topics: 2-Methoxyestradiol; Antineoplastic Agents; Boronic Acids; Bortezomib; Cell Differentiation; DNA-Binding Proteins; Drug Resistance, Neoplasm; Estradiol; Humans; Multiple Myeloma; Pyrazines; Regulatory Factor X Transcription Factors; Transcription Factors; Tretinoin; Tumor Cells, Cultured; X-Box Binding Protein 1 | 2012 |
2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells.
Topics: 2-Methoxyestradiol; Animals; Apoptosis; Bone Marrow Cells; Cytokines; Drug Resistance; Estradiol; Humans; Mice; Mice, SCID; Mitochondrial Proteins; Multiple Myeloma; Neoplasms, Experimental; Neovascularization, Pathologic; Signal Transduction; Stromal Cells; Tumor Cells, Cultured | 2002 |
Promising preclinical activity of 2-methoxyestradiol in multiple myeloma.
Topics: 2-Methoxyestradiol; Animals; Apoptosis; Cell Division; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Estradiol; Humans; Mice; Mice, SCID; Multiple Myeloma; Neoplasms, Experimental; Plasma Cells; Tumor Cells, Cultured | 2002 |
Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays.
Topics: 2-Methoxyestradiol; Cell Cycle Proteins; Cysteine Endopeptidases; Cytoskeletal Proteins; Dexamethasone; DNA-Binding Proteins; Drug Resistance, Neoplasm; Endoplasmic Reticulum; Estradiol; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Reporter; Heat-Shock Proteins; Interleukin-6; Multienzyme Complexes; Multiple Myeloma; Neoplasm Proteins; Oligonucleotide Array Sequence Analysis; Proteasome Endopeptidase Complex; Protein Folding; Regulatory Factor X Transcription Factors; RNA, Messenger; RNA, Neoplasm; Subtraction Technique; Transcription Factors; Transfection; Tumor Cells, Cultured; Ubiquitin | 2003 |
Superoxide-dependent and -independent mitochondrial signaling during apoptosis in multiple myeloma cells.
Topics: 2-Methoxyestradiol; Acetylcysteine; Antioxidants; Apoptosis; Complement Membrane Attack Complex; Complement System Proteins; Cytochrome c Group; Dexamethasone; Drug Resistance; Estradiol; Glycoproteins; Humans; Membrane Potentials; Mitochondria; Multiple Myeloma; Signal Transduction; Superoxides; Tumor Cells, Cultured | 2003 |
2-Methoxyestardiol and bortezomib/proteasome-inhibitor overcome dexamethasone-resistance in multiple myeloma cells by modulating Heat Shock Protein-27.
Topics: 2-Methoxyestradiol; Actins; Antineoplastic Agents; Boronic Acids; Bortezomib; Dexamethasone; Drug Resistance, Neoplasm; Estradiol; Heat-Shock Proteins; Humans; Multiple Myeloma; Peptides; Proteasome Inhibitors; Pyrazines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
[Effect of 2-methoxyestradiol on proliferation and apoptosis of myeloma cell lines].
Topics: 2-Methoxyestradiol; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Proliferation; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Humans; Multiple Myeloma; Oxides; Time Factors; Tumor Cells, Cultured | 2005 |
[Effect of 2-methoxyestradiol on cell differentiation of myeloma cell line CZ-1].
Topics: 2-Methoxyestradiol; Cell Differentiation; Cell Line, Tumor; Dose-Response Relationship, Drug; Estradiol; Flow Cytometry; Humans; Integrin alpha5; Multiple Myeloma; Tubulin Modulators | 2005 |
[Investigation of the effect of 2-methoxyestradiol and arsenic trioxide on the apoptosis-associated gene expression profile of myeloma cells].
Topics: 2-Methoxyestradiol; Apoptosis; Arsenic Trioxide; Arsenicals; Cell Line, Tumor; Estradiol; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Oligonucleotide Array Sequence Analysis; Oxides; Reverse Transcriptase Polymerase Chain Reaction; Tubulin Modulators | 2005 |
2-Methoxyestradiol at low dose induces differentiation of myeloma cells.
Topics: 2-Methoxyestradiol; Base Sequence; Cell Differentiation; Cell Line, Tumor; DNA Primers; DNA-Binding Proteins; Dose-Response Relationship, Drug; Estradiol; Humans; Multiple Myeloma; Nuclear Proteins; Regulatory Factor X Transcription Factors; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription Factors; X-Box Binding Protein 1 | 2005 |
Preliminary investigation of 2-methoxyestradiol inducing differentiation of myeloma cell line CZ-1.
Topics: 2-Methoxyestradiol; Cell Line, Tumor; Cell Transformation, Neoplastic; Estradiol; Humans; Immunoglobulin lambda-Chains; Integrin alpha3; Multiple Myeloma | 2006 |
[Effect of 2-methoxyestradiol on differentiation of primary myeloma cells].
Topics: 2-Methoxyestradiol; Adult; Aged; Apoptosis; Cell Transformation, Neoplastic; Estradiol; Female; Humans; Immunomagnetic Separation; Male; Middle Aged; Multiple Myeloma; Syndecan-1; Tumor Cells, Cultured | 2006 |
Integrated molecular profiling of SOD2 expression in multiple myeloma.
Topics: 2-Methoxyestradiol; Animals; Apoptosis; Cell Line, Tumor; DNA Damage; Estradiol; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Neoplasm Proteins; Proteomics; Reactive Oxygen Species; Signal Transduction; Superoxide Dismutase; Tubulin Modulators | 2007 |
Coordination of upregulated XBP-1 and downregulated c-myc during myeloma cell differentiation induced by 2-methoxyestradiol.
Topics: 2-Methoxyestradiol; Blotting, Western; Cell Cycle; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; DNA Primers; DNA-Binding Proteins; Estradiol; Flow Cytometry; Humans; Multiple Myeloma; Nuclear Proteins; Positive Regulatory Domain I-Binding Factor 1; Proto-Oncogene Proteins c-myc; Regulatory Factor X Transcription Factors; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription Factors; Tubulin Modulators; X-Box Binding Protein 1 | 2007 |
[Regulation of c-myc expression by Blimp-1 during the differentiation of myeloma cells].
Topics: 2-Methoxyestradiol; Cell Differentiation; Cell Line, Tumor; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Positive Regulatory Domain I-Binding Factor 1; Proto-Oncogene Proteins c-myc; Repressor Proteins; RNA, Messenger; Transcription Factors | 2007 |
Transcription factors Xbp-1, Blimp-1, and BSAP are involved in the regulation of plasmacytic differentiation induced by 2-methoxyestradiol in myeloma cell lines.
Topics: 2-Methoxyestradiol; Cell Differentiation; Cell Line, Tumor; DNA-Binding Proteins; Dose-Response Relationship, Drug; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Nuclear Proteins; Oligodeoxyribonucleotides, Antisense; PAX5 Transcription Factor; Plasma Cells; Positive Regulatory Domain I-Binding Factor 1; Regulatory Factor X Transcription Factors; Repressor Proteins; Syndecan-1; Transcription Factors; Tubulin Modulators; Up-Regulation; X-Box Binding Protein 1 | 2007 |
Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib.
Topics: 2-Methoxyestradiol; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; beta Catenin; Blotting, Western; Boronic Acids; Bortezomib; Cell Proliferation; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Multiple Myeloma; Oxides; Proteasome Inhibitors; Pyrazines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Tumor Cells, Cultured | 2008 |