Page last updated: 2024-08-24

2-methoxyestradiol and Hypertension

2-methoxyestradiol has been researched along with Hypertension in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (23.08)29.6817
2010's4 (30.77)24.3611
2020's6 (46.15)2.80

Authors

AuthorsStudies
Bonventre, JV; Dutta, SR; Gonzalez, FJ; Lew, J; Malik, KU; Motiwala, M; Shin, JS; Singh, P; Song, CY1
Gillespie, DG; Jackson, EK; Tofovic, SP1
Dutta, SR; Gonzalez, FJ; Malik, KU; Singh, P; Song, CY1
Abdel-Naim, AB; Ashour, OM; Azhar, AS; Zaher, ZF1
Iijima, H; Itakura, A; Kanasaki, K; Koya, D; Kumagai, A; Sohara, E; Takeda, S; Uchida, S1
Rios, FJ; Touyz, RM1
Davidge, KN; Gonzalez, FJ; Katsurada, A; Khan, NS; Majid, DSA; Malik, KU; Navar, LG; Pingili, AK; Thirunavukkarasu, S1
Chen, L; Mao, Y; Song, J; Wu, Z; Yang, C; Yuan, J; Zhang, L; Zhu, W; Zou, X1
Bastacky, SI; Jackson, EK; Salah, E; Tofovic, SP1
Bonacasa, B; Fenoy, FJ; Hernández, I; Lopez, B; Quesada, T; Rodriguez, F; Sanchez, ML1
Gui, Y; Li, D; Li, J; Singh, P; Yu, Y; Yuan, W; Zheng, XL1
Gui, Y; He, JY; Walsh, MP; Yang, SH; Yin, H; Zheng, XL1
Ahmad, S; Augustin, HG; Folkman, J; Gattone, VH; Hamano, Y; Kalluri, R; Kanasaki, K; Palmsten, K; Parry, S; Strauss, JF; Sugimoto, H; Xie, L1

Other Studies

13 other study(ies) available for 2-methoxyestradiol and Hypertension

ArticleYear
2-Methoxyestradiol Ameliorates Angiotensin II-Induced Hypertension by Inhibiting Cytosolic Phospholipase A
    Hypertension (Dallas, Tex. : 1979), 2021, Volume: 78, Issue:5

    Topics: 2-Methoxyestradiol; 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Collagen; Cytochrome P-450 CYP1A1; Female; Group IV Phospholipases A2; Hypertension; Mice; Reactive Oxygen Species; Receptors, Prostaglandin E, EP3 Subtype

2021
DPP4 Inhibition, NPY
    The Journal of pharmacology and experimental therapeutics, 2020, Volume: 373, Issue:1

    Topics: 2-Methoxyestradiol; Animals; Cell Proliferation; Cells, Cultured; Chemokine CXCL12; Collagen; Dipeptidyl-Peptidase IV Inhibitors; Female; Hypertension; Male; Neuropeptide Y; Peptide Fragments; Peptide YY; Rats; Rats, Inbred SHR; Rats, Inbred WKY

2020
Central CYP1B1 (Cytochrome P450 1B1)-Estradiol Metabolite 2-Methoxyestradiol Protects From Hypertension and Neuroinflammation in Female Mice.
    Hypertension (Dallas, Tex. : 1979), 2020, Volume: 75, Issue:4

    Topics: 2-Methoxyestradiol; Angiotensin II; Animals; Astrocytes; Baroreflex; Blood Pressure; Brain; Cytochrome P-450 CYP1B1; Estradiol; Female; Hypertension; Inflammation; Mice; Mice, Knockout; Microglia; Neuroprotective Agents; Oxidative Stress; Reactive Oxygen Species

2020
2-Methoxyestradiol ameliorates metabolic syndrome-induced hypertension and catechol-O-methyltransferase inhibited expression and activity in rats.
    European journal of pharmacology, 2020, Sep-05, Volume: 882

    Topics: 2-Methoxyestradiol; Animals; Antihypertensive Agents; Aorta; Blood Glucose; Blood Pressure; Brain Stem; Catechol O-Methyltransferase; Epinephrine; Hypertension; Insulin; Kidney; Liver; Male; Metabolic Syndrome; Myocardium; Norepinephrine; Rats, Wistar; Triglycerides

2020
Dietary Magnesium Insufficiency Induces Salt-Sensitive Hypertension in Mice Associated With Reduced Kidney Catechol-O-Methyl Transferase Activity.
    Hypertension (Dallas, Tex. : 1979), 2021, Volume: 78, Issue:1

    Topics: 2-Methoxyestradiol; Animals; Blood Pressure; Catechol O-Methyltransferase; Dietary Supplements; Female; Hypertension; Kidney; Magnesium; Male; Mice, Inbred C57BL; Mice, Inbred DBA; Ovariectomy; Sodium Chloride, Dietary

2021
Mg
    Hypertension (Dallas, Tex. : 1979), 2021, Volume: 78, Issue:1

    Topics: 2-Methoxyestradiol; Animals; Blood Pressure; Catechol O-Methyltransferase; Dietary Supplements; Down-Regulation; Hypertension; Magnesium; Mice, Knockout; Sodium Chloride, Dietary

2021
2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice.
    Hypertension (Dallas, Tex. : 1979), 2017, Volume: 69, Issue:6

    Topics: 2-Methoxyestradiol; Angiotensin II; Animals; Blood Pressure; Blood Pressure Determination; Cytochrome P-450 CYP1B1; Disease Models, Animal; Estradiol; Female; Hypertension; Kidney Diseases; Kidney Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovariectomy; Random Allocation; Reactive Oxygen Species; Sensitivity and Specificity; Sex Factors

2017
Endogenous hormone 2-methoxyestradiol suppresses venous hypertension-induced angiogenesis through up- and down-regulating p53 and id-1.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:2

    Topics: 2-Methoxyestradiol; Animals; Basal Ganglia; Cell Movement; Down-Regulation; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Inhibitor of Differentiation Protein 1; Male; Microvessels; Models, Biological; Neovascularization, Pathologic; Rats, Sprague-Dawley; Tumor Suppressor Protein p53; Up-Regulation

2018
2-Methoxyestradiol Attenuates Angiotensin II-Induced Hypertension, Cardiovascular Remodeling, and Renal Injury.
    Journal of cardiovascular pharmacology, 2019, Volume: 73, Issue:3

    Topics: 2-Methoxyestradiol; Angiotensin II; Animals; Blood Pressure; Fibrosis; Glomerular Filtration Rate; Hypertension; Hypertrophy, Left Ventricular; Isoproterenol; Kidney; Kidney Diseases; Male; Rats, Sprague-Dawley; Renin-Angiotensin System; Vascular Remodeling; Ventricular Function, Left; Ventricular Remodeling

2019
2-Methoxyestradiol attenuates hypertension and coronary vascular remodeling in spontaneously hypertensive rats.
    Maturitas, 2008, Dec-20, Volume: 61, Issue:4

    Topics: 2-Methoxyestradiol; Animals; Coronary Vessels; Estradiol; Female; Hypertension; Male; Menopause; Mitogen-Activated Protein Kinase 3; Ovariectomy; Rats; Rats, Inbred Dahl; Signal Transduction

2008
Estrogen metabolite 2-methoxyestradiol prevents hypertension in deoxycorticosterone acetate-salt rats.
    Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:1

    Topics: 2-Methoxyestradiol; Animals; Antihypertensive Agents; Arterial Pressure; Data Interpretation, Statistical; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Estrogens; Hypertension; Rats; Time Factors; Treatment Outcome

2013
Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 292, Issue:3

    Topics: 2-Methoxyestradiol; Aneuploidy; Aorta; Cell Division; Cyclin-Dependent Kinase 2; DNA Replication; Estradiol; Gene Expression Regulation, Enzymologic; Humans; Hypertension; Muscle, Smooth, Vascular

2007
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia.
    Nature, 2008, Jun-19, Volume: 453, Issue:7198

    Topics: 2-Methoxyestradiol; Albumins; Animals; Blood Pressure; Catechol O-Methyltransferase; Creatinine; Disease Models, Animal; Estradiol; Female; Humans; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Killer Cells, Natural; Litter Size; Male; Mice; Placenta; Pre-Eclampsia; Pregnancy; Proteinuria; Vascular Endothelial Growth Factor Receptor-1

2008