Compounds > 2-methoxyestradiol

Page last updated: 2024-08-24

2-methoxyestradiol and Hepatocellular Carcinoma

2-methoxyestradiol has been researched along with Hepatocellular Carcinoma in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (8.33)	18.2507
2000's	7 (58.33)	29.6817
2010's	3 (25.00)	24.3611
2020's	1 (8.33)	2.80

Authors

Authors	Studies
Chen, Z; Guo, H; Hu, W; Jiao, M; Jin, T; Li, Y; Lu, M; Ni, J; Wang, Z; Wu, H; Yang, Y; Yao, Y; Yuan, A; Zhang, H; Zheng, S	1
Mei, J; Tang, X; Tao, H	1
Dong, X; Jiang, X; Li, G; Li, J; Ma, L; Ni, S; Qiao, H; Sun, X; Zhao, D; Zhu, H	1
Chen, GG; Ho, RL; Hu, B; Lai, PB; Lee, CG; Leung, BC; Liu, Y; Lu, G; Ren, J; Su, X; Wang, Y; Yang, S	1
Chi, CW; Ko, PH; Liu, TY; Lui, WY; Uen, YH; Yin, PH	1
Abdel-Naim, AB; El Naga, RN; El-Demerdash, E; El-Merzabani, M; Youssef, SS	1
Chang, YF; Chi, CW; Hsu, YC; Hung, HF; Lee, HJ; Lui, WY; Wang, JJ	1
Bachem, MG; Mukhopadhyay, T; Neuhaus, P; Nussler, AK; Pratschke, J; Rueggeberg, A; Scheunert, S; Schumacher, G; Spinelli, A	1
Carr, BI; Kar, S; Wang, M	1
Adlercreutz, H; Carson, M; Loukovaara, M	1
Chau, GY; Chi, CW; Lin, HL; Liu, TY; Lui, WY	2

Other Studies

12 other study(ies) available for 2-methoxyestradiol and Hepatocellular Carcinoma

Article	Year
2-Methoxyestradiol synergizes with Erlotinib to suppress hepatocellular carcinoma by disrupting the PLAGL2-EGFR-HIF-1/2α signaling loop. Pharmacological research, 2021, Volume: 169 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Hepatocellular; Cell Line, Tumor; DNA-Binding Proteins; Drug Synergism; ErbB Receptors; Erlotinib Hydrochloride; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Neoplasm Transplantation; RNA-Binding Proteins; Signal Transduction; Transcription Factors	2021
The anticancer effects of 2-methoxyestradiol on human huh7 cells in vitro and in vivo. Biochemical and biophysical research communications, 2019, 05-07, Volume: 512, Issue:3 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Humans; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude	2019
2-Methoxyestradiol synergizes with sorafenib to suppress hepatocellular carcinoma by simultaneously dysregulating hypoxia-inducible factor-1 and -2. Cancer letters, 2014, Dec-01, Volume: 355, Issue:1 Topics: 2-Methoxyestradiol; Active Transport, Cell Nucleus; Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Hepatocellular; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Liver Neoplasms; Male; Mice, Inbred BALB C; Mice, Nude; Neovascularization, Pathologic; Niacinamide; Phenylurea Compounds; RNA Interference; Signal Transduction; Sorafenib; Time Factors; Transfection; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays	2014
Cytochrome P450 1A2 Metabolizes 17β-Estradiol to Suppress Hepatocellular Carcinoma. PloS one, 2016, Volume: 11, Issue:4 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cytochrome P-450 CYP1A2; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Humans; Liver; Liver Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Niacinamide; Phenylurea Compounds; Receptors, Estrogen; Sorafenib; Tumor Suppressor Protein p53	2016
Glucocorticoid protects hepatoma cells against metabolic stress-induced cell death. International journal of oncology, 2008, Volume: 33, Issue:6 Topics: 2-Methoxyestradiol; Animals; Apoptosis; bcl-X Protein; Carcinoma, Hepatocellular; Caspases; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dexamethasone; Dose-Response Relationship, Drug; Estradiol; Glucocorticoids; Humans; Lactic Acid; Liver Neoplasms; Mice; Proto-Oncogene Proteins c-bcl-2; Stress, Physiological	2008
Cytotoxic effects of 2-methoxyestradiol in the hepatocellular carcinoma cell line HepG2. Pharmacology, 2009, Volume: 84, Issue:1 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Caspase 9; Cell Line, Tumor; Dose-Response Relationship, Drug; Estradiol; Flow Cytometry; G2 Phase; Humans; Liver Neoplasms; Vascular Endothelial Growth Factor A	2009
Quercetin induces oxidative stress and potentiates the apoptotic action of 2-methoxyestradiol in human hepatoma cells. Nutrition and cancer, 2009, Volume: 61, Issue:5 Topics: 2-Methoxyestradiol; Annexin A5; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Survival; Estradiol; Flow Cytometry; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial; Oxidative Stress; Quercetin; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Superoxide Dismutase	2009
A very low toxic agent induces apoptosis and reduces growth of human hepatocellular carcinoma cells. Journal of gastroenterology and hepatology, 2006, Volume: 21, Issue:7 Topics: 2-Methoxyestradiol; Apoptosis; Carcinoma, Hepatocellular; Cell Count; Cell Line, Tumor; Cell Proliferation; Estradiol; Hepatocytes; Humans; In Vitro Techniques; Liver Neoplasms	2006
2-Methoxyestradiol inhibits hepatocellular carcinoma cell growth by inhibiting Cdc25 and inducing cell cycle arrest and apoptosis. Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:5 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; cdc25 Phosphatases; Cell Cycle; Cell Division; Cell Proliferation; Cells, Cultured; DNA; Estradiol; G2 Phase; Hepatocytes; Immunoprecipitation; Liver Neoplasms, Experimental; Male; Neoplasm Transplantation; Rats; Rats, Inbred F344; Tubulin Modulators	2008
Regulation of sex-hormone-binding globulin production by endogenous estrogens in vitro. Biochemical and biophysical research communications, 1995, Jan-26, Volume: 206, Issue:3 Topics: 2-Methoxyestradiol; Carcinoma, Hepatocellular; Estradiol; Estriol; Estrogens; Estrone; Humans; Hydroxyestrones; Liver Neoplasms; Receptors, Estrogen; RNA, Messenger; Sex Hormone-Binding Globulin; Tumor Cells, Cultured	1995
Comparison of 2-methoxyestradiol-induced, docetaxel-induced, and paclitaxel-induced apoptosis in hepatoma cells and its correlation with reactive oxygen species. Cancer, 2000, Sep-01, Volume: 89, Issue:5 Topics: 2-Methoxyestradiol; Antineoplastic Agents, Phytogenic; Apoptosis; Carcinoma, Hepatocellular; Cell Cycle; Cell Survival; DNA Fragmentation; Docetaxel; Estradiol; Flow Cytometry; Humans; Liver Neoplasms; Microtubules; Paclitaxel; Reactive Oxygen Species; Taxoids; Tumor Cells, Cultured	2000
Male predominance in hepatocellular carcinoma: new insight and a possible therapeutic alternative. Medical hypotheses, 2000, Volume: 55, Issue:4 Topics: 2-Methoxyestradiol; Androgens; Carcinoma, Hepatocellular; Combined Modality Therapy; Estradiol; Female; Humans; Liver; Liver Neoplasms; Male; Models, Biological; Sex Factors	2000