Page last updated: 2024-08-24

2-methoxyestradiol and Disease Models, Animal

2-methoxyestradiol has been researched along with Disease Models, Animal in 53 studies

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (1.89)	18.2507
2000's	21 (39.62)	29.6817
2010's	27 (50.94)	24.3611
2020's	4 (7.55)	2.80

Authors

Authors	Studies
Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ	1
Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV	1
Cao, F; Jiang, X; Li, J; Lu, H; Shan, F; Xia, Y; Xiong, A; Xiong, R; Xu, J	1
Li, M; Liu, C; Liu, S; Lu, J; Tang, J; Zhou, X; Zhu, L	1
He, S; Lou, Q; Luo, J; Shi, C; Yin, Z; Zhai, G; Zhang, X; Zheng, F	1
Azab, SS; Elzankalony, YA; Nasr, M; Said, AM; Salah Eldin, RA; Zaki, RG	1
Davidge, KN; Gonzalez, FJ; Katsurada, A; Khan, NS; Majid, DSA; Malik, KU; Navar, LG; Pingili, AK; Thirunavukkarasu, S	1
Dalman, RL; Fu, W; Ge, Y; Huang, J; Michie, SA; Wang, L; Wang, W; Wang, Y; Xu, B; Xuan, H	1
Antonio-Andres, G; Baay-Guzman, GJ; Barrios-Payan, J; Duran-Padilla, MA; Hernandez-Pando, R; Huerta-Yepez, S; Klunder-Klunder, M; Mata-Espinosa, D; Rangel-Santiago, J; Tirado-Rodriguez, B; Vega, MI	1
Docherty, CK; MacLean, MR; Nilsen, M	1
Hales, DB; Hales, K; Pal, P; Petrik, J	1
Ehteda, A; Galettis, P; Morris, DL; Pillai, K	1
Cho, CW; Hsu, CY; Lee, HT; Lee, SD; Lee, W; Lin, CH; Lin, SZ; Okano, H; Shyu, WC; Su, CY; Wang, HJ; Yu, YL	1
Chen, G; Chen, J; Gu, C; Hu, Q; Li, J; Mo, H; Wang, L; Wu, C; Yan, F; Zhang, P	1
Durden, DL; Joshi, S; Kesari, S; Makale, MT; Muh, CR; Singh, AR	1
Evans, CE; Grover, SP; Humphries, J; Kim, JW; Modarai, B; Saha, P; Smith, A	1
Chen, J; Huang, T; Huang, W; Peng, Z; Xie, C; Yu, L; Zhang, Z; Zhu, D	1
Chen, L; Mao, Y; Zhou, L; Zhu, W; Zou, X	1
He, F; Meng, Q; Sun, Y; Wang, C; Wang, W; Yang, J	1
Gao, H; Shen, Y; Sun, Q; Tang, H; Yan, C; Yuan, D	1
Chen, W; Jadhav, V; Tang, J; Zhang, JH	2
Banquerigo, ML; Brahn, E; Fogler, WE; Lee, JK; Park, EJ; Plum, SM	1
Baay-Guzman, GJ; Bonavida, B; Garcia-Zepeda, R; Gonzalez-Bonilla, C; Hernandez-Pando, R; Huerta-Yepez, S; Vega, MI	1
Banerjee, S; Chambers, AE; Randeva, H	1
Bedolla, R; Ganapathy, M; Ghosh, R; Jianping, X; Kumar, AP; Olumi, AF; Schoolfield, J; Troyer, DA; Yeh, IT; Zhang, X	1
Dobos, J	1
Fogler, WE; Moore, EG; Park, EJ; Plum, SM; Sidor, CF; Strawn, SJ	1
Chen, C; Ostrowski, RP; Tang, J; Zhang, JH; Zhou, C	1
Cao, Y; Fan, ZK; Wang, YF; Wang, YS; Yu, DS; Zhang, YQ	1
Belibi, F; Edelstein, CL; Jani, A; Ljubanovic, DG; Ravichandran, K; Segvic, AB; Zafar, I	1
Andréasson, E; Carlsten, H; Islander, U; Karlsson, A; Ohlsson, C; Stubelius, A; Tivesten, A	1
Babbs, RK; Corwin, RL; Wojnicki, FH	1
Chen, SD; Ding, JQ; Ma, JF; Pan, J; Wang, XQ; Xin, XY; Yang, GY	1
Ali, A; Ding, JY; Ding, Y; Dornbos, D; Geng, X; Guthikonda, M; Konakondla, S; Kreipke, CW; Peng, C; Rafols, JA; Schafer, S; Sikharam, C; Zwagerman, NT	1
Chen, G; He, WC; Huo, L; Liu, HX; Ma, C; Meng, CJ; Shen, XM; Shu, Z; Sun, XB; Wang, Z; Zhang, J; Zhu, GQ	1
Gui, Y; Li, D; Li, J; Singh, P; Yu, Y; Yuan, W; Zheng, XL	1
Banerjee, S; Banerjee, SK; Borrego-Diaz, E; Burns, D; Das, A; Haque, I; Jha, S; Kambhampati, S; Rajewski, RA; Tanol, M; Van Veldhuizen, PJ	1
Bobowiec, R; Kostro, K; Lisiecka, U; Wojcik, M	1
Tímár, J	1
Anderson, RL; Eckhardt, BL; Harris, T; Quan, L; Schuliga, M; Stewart, AG; Sutherland, TE	1
Arevalo, N; Garcia, GE; Kraft, SL; Kumar, AP; Lucia, MS; Slaga, TJ; Strange, R; Wisniewski, HG	1
Calvo, A; Charles, R; Green, JE; Huh, JI	1
Neuhaus, P; Schumacher, G	1
Birsner, AE; D'Amato, RJ; Funakoshi, T	1
Chen, C; Lei, J; Liu, J; Wang, K; Yan, J; Yang, L; Zhou, C	1
Brat, DJ; Cho, HT; Devi, S; Escuin, D; Giannakakou, P; Kang, SH; Lavallee, TM; Liang, Z; Mao, H; Olson, JJ; Shim, H; Simons, JW; Van Meir, EG; Zhang, Z	1
Chen, C; Han, J; Hu, Q; Lei, J; Luan, L; Nanda, A; Qin, L; Shi, X; Wang, K; Yan, J; Yang, L; Zhou, C	1
Dach, N; Jadhav, V; Matchett, GA; Zhang, JH; Zhou, D	1
Becker, CM; Bernhardt, W; Birsner, A; Cramer, T; D'Amato, RJ; Folkman, J; Funakoshi, T; Rohwer, N	1
Ahmad, S; Augustin, HG; Folkman, J; Gattone, VH; Hamano, Y; Kalluri, R; Kanasaki, K; Palmsten, K; Parry, S; Strauss, JF; Sugimoto, H; Xie, L	1
Kataoka, M; Mukhopadhyay, T; Roth, JA; Schumacher, G	1
Anderson, C; D'Ippolito, G; Herron, A; Howard, GA; Perez-Stable, CM; Qadan, LR; Roos, BA	1

Reviews

1 review(s) available for 2-methoxyestradiol and Disease Models, Animal

Article	Year
[2-Methoxyestradiol -- a new compound for cancer treatment]. Deutsche medizinische Wochenschrift (1946), 2006, Apr-13, Volume: 131, Issue:15 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Disease Models, Animal; Estradiol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Neovascularization, Pathologic; Spindle Apparatus; Treatment Outcome; Tubulin Modulators	2006

Article

Year

[2-Methoxyestradiol -- a new compound for cancer treatment].

Deutsche medizinische Wochenschrift (1946), 2006, Apr-13, Volume: 131, Issue:15

Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Disease Models, Animal; Estradiol; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasms; Neovascularization, Pathologic; Spindle Apparatus; Treatment Outcome; Tubulin Modulators

2006

Other Studies

52 other study(ies) available for 2-methoxyestradiol and Disease Models, Animal

Article	Year
Inhibition of natriuretic peptide receptor 1 reduces itch in mice. Science translational medicine, 2019, 07-10, Volume: 11, Issue:500 Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries	2019
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. Proceedings of the National Academy of Sciences of the United States of America, 2020, 12-08, Volume: 117, Issue:49 Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection	2020
Inhibition of HIF-1α-AQP4 axis ameliorates brain edema and neurological functional deficits in a rat controlled cortical injury (CCI) model. Scientific reports, 2022, 02-17, Volume: 12, Issue:1 Topics: 2-Methoxyestradiol; Animals; Antibodies; Aquaporin 4; Blood-Brain Barrier; Brain Edema; Brain Injuries, Traumatic; Cerebral Cortex; Conversion Disorder; Disease Models, Animal; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Injections, Intravenous; Learning; Male; Memory; Memory Disorders; Neurons; Rats, Sprague-Dawley	2022
Inhibition of JAK1/STAT3 pathway by 2-methoxyestradiol ameliorates psoriatic features in vitro and in an imiquimod-induced psoriasis-like mouse model. European journal of pharmacology, 2022, Oct-15, Volume: 933 Topics: 2-Methoxyestradiol; Animals; Cell Proliferation; Dermatitis; Disease Models, Animal; Endothelial Cells; Humans; Imiquimod; Interleukin-17; Janus Kinase 1; Keratinocytes; Mercaptoethanol; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ointments; Psoriasis; Skin; STAT3 Transcription Factor; Vascular Endothelial Growth Factor A	2022
Deletion of narfl leads to increased oxidative stress mediated abnormal angiogenesis and digestive organ defects in zebrafish. Redox biology, 2020, Volume: 28 Topics: 2-Methoxyestradiol; Animals; Disease Models, Animal; Embryonic Development; Gastrointestinal Tract; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Hypoxia-Inducible Factor 1, alpha Subunit; Iron-Sulfur Proteins; Neovascularization, Pathologic; Oxidative Stress; Zebrafish; Zebrafish Proteins	2020
Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model. BMC ophthalmology, 2017, Apr-04, Volume: 17, Issue:1 Topics: 2-Methoxyestradiol; Animals; Animals, Newborn; Disease Models, Animal; Disease Progression; Estradiol; Immunohistochemistry; Intravitreal Injections; Male; Photomicrography; Prospective Studies; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Tubulin Modulators; Vascular Endothelial Growth Factor A	2017
2-Methoxyestradiol Reduces Angiotensin II-Induced Hypertension and Renal Dysfunction in Ovariectomized Female and Intact Male Mice. Hypertension (Dallas, Tex. : 1979), 2017, Volume: 69, Issue:6 Topics: 2-Methoxyestradiol; Angiotensin II; Animals; Blood Pressure; Blood Pressure Determination; Cytochrome P-450 CYP1B1; Disease Models, Animal; Estradiol; Female; Hypertension; Kidney Diseases; Kidney Function Tests; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovariectomy; Random Allocation; Reactive Oxygen Species; Sensitivity and Specificity; Sex Factors	2017
Hypoxia-inducible factor 1 in clinical and experimental aortic aneurysm disease. Journal of vascular surgery, 2018, Volume: 68, Issue:5 Topics: 2-Methoxyestradiol; Aged; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Case-Control Studies; CD4-Positive T-Lymphocytes; Chemotaxis, Leukocyte; Digoxin; Disease Models, Animal; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Male; Mice, Inbred C57BL; Middle Aged; Neovascularization, Pathologic; Pancreatic Elastase; Procollagen-Proline Dioxygenase; Signal Transduction; Up-Regulation	2018
Dual role of hypoxia-inducible factor 1 α in experimental pulmonary tuberculosis: its implication as a new therapeutic target. Future microbiology, 2018, 06-01, Volume: 13 Topics: 2-Methoxyestradiol; Animals; Antitubercular Agents; Apoptosis; Disease Models, Animal; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Macrophages; Male; Mice; Mice, Inbred BALB C; Tuberculosis, Pulmonary	2018
Influence of 2-Methoxyestradiol and Sex on Hypoxia-Induced Pulmonary Hypertension and Hypoxia-Inducible Factor-1-α. Journal of the American Heart Association, 2019, 03-05, Volume: 8, Issue:5 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Cytoskeleton; Disease Models, Animal; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pulmonary Arterial Hypertension; Pulmonary Artery; Rats, Sprague-Dawley; Sex Factors; Signal Transduction; Vascular Remodeling	2019
Pro-apoptotic and anti-angiogenic actions of 2-methoxyestradiol and docosahexaenoic acid, the biologically derived active compounds from flaxseed diet, in preventing ovarian cancer. Journal of ovarian research, 2019, May-25, Volume: 12, Issue:1 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Cell Line, Tumor; Chickens; Chorioallantoic Membrane; Dietary Supplements; Disease Models, Animal; Docosahexaenoic Acids; Female; Flax; Humans; MAP Kinase Signaling System; Neovascularization, Pathologic; Ovarian Neoplasms; Ovary; Seeds	2019
Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice. BMC cancer, 2013, Feb-23, Volume: 13 Topics: 2-Methoxyestradiol; Albendazole; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colchicine; Colorectal Neoplasms; Cytotoxins; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Estradiol; Female; HCT116 Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Prostatic Neoplasms; Tubulin Modulators	2013
Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model. Neurobiology of disease, 2013, Volume: 58 Topics: 2-Methoxyestradiol; Animals; Animals, Newborn; Antigens, CD34; Cell Proliferation; Cord Blood Stem Cell Transplantation; Disease Models, Animal; Estradiol; Glucose; Green Fluorescent Proteins; Guanine Nucleotide Exchange Factors; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Infarction, Middle Cerebral Artery; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mesenchymal Stem Cells; Mice, Transgenic; Nerve Regeneration; Neuronal Plasticity; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Tubulin Modulators; Up-Regulation	2013
Inhibiting HIF-1α by 2ME2 ameliorates early brain injury after experimental subarachnoid hemorrhage in rats. Biochemical and biophysical research communications, 2013, Aug-02, Volume: 437, Issue:3 Topics: 2-Methoxyestradiol; Animals; Brain Injuries; Disease Models, Animal; Endovascular Procedures; Estradiol; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Membrane Proteins; Mitochondrial Proteins; Neuroprotective Agents; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Vascular Endothelial Growth Factor A	2013
PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression. Journal of neuro-oncology, 2014, Volume: 116, Issue:1 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Chromones; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Female; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Morpholines; PTEN Phosphohydrolase; Xenograft Model Antitumor Assays	2014
Suppression of angiogenic response in local vein wall is associated with reduced thrombus resolution. Thrombosis research, 2014, Volume: 134, Issue:3 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Cell Proliferation; Disease Models, Animal; Down-Regulation; Estradiol; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Mice, Inbred C57BL; Neovascularization, Physiologic; Placenta Growth Factor; Pregnancy Proteins; Time Factors; Vascular Endothelial Growth Factor A; Vena Cava, Inferior; Venous Thrombosis	2014
Hypoxia-inducible factor-1α upregulation in microglia following hypoxia protects against ischemia-induced cerebral infarction. Neuroreport, 2014, Oct-01, Volume: 25, Issue:14 Topics: 2-Methoxyestradiol; Animals; Blotting, Western; Brain; Brain Ischemia; Cell Line; Central Nervous System Agents; Cerebral Infarction; Disease Models, Animal; Estradiol; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Mice, Inbred C57BL; Microglia; Random Allocation; Up-Regulation	2014
Effectiveness of 2-methoxyestradiol in alleviating angiogenesis induced by intracranial venous hypertension. Journal of neurosurgery, 2016, Volume: 125, Issue:3 Topics: 2-Methoxyestradiol; Animals; Disease Models, Animal; Estradiol; Intracranial Hypertension; Male; Neovascularization, Pathologic; Rats; Rats, Sprague-Dawley; Treatment Outcome	2016
Inhibiting HIF-1α Decreases Expression of TNF-α and Caspase-3 in Specific Brain Regions Exposed Kainic Acid-Induced Status Epilepticus. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2016, Volume: 38, Issue:1 Topics: 2-Methoxyestradiol; Amygdala; Animals; Brain; Caspase 3; Disease Models, Animal; Estradiol; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Kainic Acid; Male; Parietal Lobe; Rats; Rats, Wistar; Status Epilepticus; Tumor Necrosis Factor-alpha; Up-Regulation	2016
2-Methoxyestradiol protects against IgG immune complex-induced acute lung injury by blocking NF-κB and CCAAT/enhancer-binding protein β activities. Molecular immunology, 2017, Volume: 85 Topics: 2-Methoxyestradiol; Acute Lung Injury; Animals; Antigen-Antibody Complex; Blotting, Western; CCAAT-Enhancer-Binding Protein-beta; Disease Models, Animal; Estradiol; Immunoglobulin G; Macrophages, Alveolar; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Real-Time Polymerase Chain Reaction	2017
HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. Neurobiology of disease, 2008, Volume: 31, Issue:3 Topics: 2-Methoxyestradiol; Amino Acids, Dicarboxylic; Animals; Animals, Newborn; Blood-Brain Barrier; Brain; Brain Edema; Brain Infarction; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estradiol; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Rats; Tubulin Modulators; Vascular Endothelial Growth Factor A	2008
An angiogenesis inhibitor, 2-methoxyestradiol, involutes rat collagen-induced arthritis and suppresses gene expression of synovial vascular endothelial growth factor and basic fibroblast growth factor. The Journal of rheumatology, 2008, Volume: 35, Issue:11 Topics: 2-Methoxyestradiol; Animals; Arthritis, Experimental; Autoantibodies; Collagen; Disease Models, Animal; Endothelial Growth Factors; Estradiol; Fibroblast Growth Factor 2; Gastric Lavage; Gene Expression; Immunohistochemistry; Infusion Pumps; Neovascularization, Pathologic; Radiography; Rats; Rats, Inbred Strains; Synovial Membrane; Tubulin Modulators; von Willebrand Factor	2008
2-Methoxyestradiol (2-ME) reduces the airway inflammation and remodeling in an experimental mouse model. Clinical immunology (Orlando, Fla.), 2008, Volume: 129, Issue:2 Topics: 2-Methoxyestradiol; Animals; Asthma; Collagen Type IV; Disease Models, Animal; Eosinophils; Estradiol; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoglobulin E; Lung; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Vascular Endothelial Growth Factor A	2008
Mouse models for preeclampsia: disruption of redox-regulated signaling. Reproductive biology and endocrinology : RB&E, 2009, Jan-15, Volume: 7 Topics: 2-Methoxyestradiol; Animals; Catechol O-Methyltransferase; Disease Models, Animal; Estradiol; Female; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mitochondrial Proteins; Oxidation-Reduction; Oxidative Stress; Pre-Eclampsia; Pregnancy; Signal Transduction; Superoxide Dismutase	2009
Involvement of FLIP in 2-methoxyestradiol-induced tumor regression in transgenic adenocarcinoma of mouse prostate model. Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Mar-01, Volume: 15, Issue:5 Topics: 2-Methoxyestradiol; Adenocarcinoma; Animals; CASP8 and FADD-Like Apoptosis Regulating Protein; Chromatin Immunoprecipitation; Disease Models, Animal; Estradiol; Fas-Associated Death Domain Protein; Humans; Immunoblotting; Immunoenzyme Techniques; Immunoprecipitation; Male; Mice; Mice, Transgenic; Promoter Regions, Genetic; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Sp1 Transcription Factor; Sp3 Transcription Factor; Transfection; Tubulin Modulators; Tumor Cells, Cultured	2009
[Endocrine factors influencing melanoma progression]. Magyar onkologia, 2009, Volume: 53, Issue:1 Topics: 2-Methoxyestradiol; Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Estradiol; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Male; Melanoma; Mice; Mice, SCID; Receptors, Glucocorticoid; Skin Neoplasms; Tubulin Modulators	2009
HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury. Acta neurochirurgica. Supplement, 2008, Volume: 102 Topics: 2-Methoxyestradiol; Analysis of Variance; Animals; Animals, Newborn; Brain Edema; Brain Infarction; Brain Injuries; Cerebral Cortex; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Functional Laterality; Gene Expression Regulation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Ischemia, Brain; Rats; Rats, Sprague-Dawley; Tetrazolium Salts; Vascular Endothelial Growth Factor A	2008
Disease modifying and antiangiogenic activity of 2-methoxyestradiol in a murine model of rheumatoid arthritis. BMC musculoskeletal disorders, 2009, May-01, Volume: 10 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Angiogenic Proteins; Animals; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Vessels; Bone Resorption; Cartilage, Articular; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Female; Joints; Mice; Mice, Inbred BALB C; Neovascularization, Pathologic; Synovial Membrane; Synovitis; Time Factors; Treatment Outcome	2009
Suppression of hypoxia-inducible factor-1alpha and its downstream genes reduces acute hyperglycemia-enhanced hemorrhagic transformation in a rat model of cerebral ischemia. Journal of neuroscience research, 2010, Volume: 88, Issue:9 Topics: 2-Methoxyestradiol; Acute Disease; Animals; Brain; Brain Ischemia; Central Nervous System Agents; Disease Models, Animal; Estradiol; Hyperglycemia; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Infarction, Middle Cerebral Artery; Intracranial Hemorrhages; Male; Rats; Rats, Sprague-Dawley; Time Factors	2010
2-Methoxyestradiol inhibits the up-regulation of AQP4 and AQP1 expression after spinal cord injury. Brain research, 2011, Jan-25, Volume: 1370 Topics: 2-Methoxyestradiol; Animals; Aquaporin 1; Aquaporin 4; Disease Models, Animal; Estradiol; Male; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries; Tubulin Modulators; Up-Regulation	2011
Hypoxia-inducible factor-1α (HIF-1α) and autophagy in polycystic kidney disease (PKD). American journal of physiology. Renal physiology, 2011, Volume: 300, Issue:5 Topics: 2-Methoxyestradiol; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Disease Models, Animal; Epithelial Cells; Estradiol; Fluorescent Antibody Technique; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron, Transmission; Microtubule-Associated Proteins; Polycystic Kidney Diseases; Rats; TRPP Cation Channels	2011
Role of 2-methoxyestradiol as inhibitor of arthritis and osteoporosis in a model of postmenopausal rheumatoid arthritis. Clinical immunology (Orlando, Fla.), 2011, Volume: 140, Issue:1 Topics: 2-Methoxyestradiol; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Estradiol; Female; Humans; Mice; Mice, Inbred DBA; Osteoporosis, Postmenopausal; Ovariectomy	2011
Effect of 2-hydroxyestradiol on binge intake in rats. Physiology & behavior, 2011, Jul-06, Volume: 103, Issue:5 Topics: 2-Methoxyestradiol; Animals; Binge-Eating Disorder; Dietary Fats; Disease Models, Animal; Dose-Response Relationship, Drug; Eating; Estradiol; Female; Male; Rats; Rats, Sprague-Dawley; Sex Characteristics	2011
2-methoxyestradiol attenuates autophagy activation after global ischemia. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 2011, Volume: 38, Issue:4 Topics: 2-Methoxyestradiol; Adenine; Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Hypoxia-Inducible Factor 1; In Situ Nick-End Labeling; Male; Membrane Proteins; Microtubule-Associated Proteins; Mitochondrial Proteins; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Tubulin Modulators; Tumor Suppressor Protein p53; Up-Regulation	2011
Glycerol accumulation in edema formation following diffuse traumatic brain injury. Neurological research, 2012, Volume: 34, Issue:5 Topics: 2-Methoxyestradiol; Animals; Aquaporins; Brain Edema; Brain Injuries; Disease Models, Animal; Estradiol; Gene Expression Regulation; Glycerol; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Rats; Rats, Sprague-Dawley; Time Factors; Tubulin Modulators	2012
Potential contribution of hypoxia-inducible factor-1α, aquaporin-4, and matrix metalloproteinase-9 to blood-brain barrier disruption and brain edema after experimental subarachnoid hemorrhage. Journal of molecular neuroscience : MN, 2012, Volume: 48, Issue:1 Topics: 2-Methoxyestradiol; Animals; Aquaporin 4; Blood-Brain Barrier; Brain Edema; Disease Models, Animal; Estradiol; Hypoxia-Inducible Factor 1, alpha Subunit; Laminin; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Minocycline; Occludin; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Tubulin Modulators; Zonula Occludens-1 Protein	2012
Estrogen metabolite 2-methoxyestradiol prevents hypertension in deoxycorticosterone acetate-salt rats. Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:1 Topics: 2-Methoxyestradiol; Animals; Antihypertensive Agents; Arterial Pressure; Data Interpretation, Statistical; Desoxycorticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Estrogens; Hypertension; Rats; Time Factors; Treatment Outcome	2013
A second-generation 2-Methoxyestradiol prodrug is effective against Barrett's adenocarcinoma in a mouse xenograft model. Molecular cancer therapeutics, 2013, Volume: 12, Issue:3 Topics: 2-Methoxyestradiol; Adenocarcinoma; Animals; Apoptosis; Barrett Esophagus; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Estradiol; Humans; Mice; Prodrugs; Xenograft Model Antitumor Assays	2013
Proliferation, differentiation and apoptosis of choline deficient ethionine supplemented diet-rat oval cells under the influence of 2-methoxyestradiol. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2012, Volume: 63, Issue:6 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Choline Deficiency; Diet; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Ethionine; Female; Liver; Rats; Rats, Wistar; Time Factors	2012
[Report of the National Oncology Research and Developement Consortium, 2003]. Magyar onkologia, 2004, Volume: 48, Issue:1 Topics: 2-Methoxyestradiol; Adult; Animals; Antineoplastic Agents; Biomarkers, Tumor; Biomedical Research; Bone Neoplasms; Breast Neoplasms; Child; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; DNA Methylation; Epoetin Alfa; Erythropoietin; Estradiol; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Markers; Head and Neck Neoplasms; Heparin, Low-Molecular-Weight; Humans; Hungary; Incidence; Male; Melanoma; Microsatellite Repeats; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Polymorphism, Genetic; Predictive Value of Tests; Recombinant Proteins; Transplantation, Heterologous	2004
2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Mar-01, Volume: 11, Issue:5 Topics: 2-Methoxyestradiol; Animals; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Estradiol; Female; Gene Expression Profiling; Humans; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous; Tumor Cells, Cultured	2005
2-Methoxyestradiol inhibits prostate tumor development in transgenic adenocarcinoma of mouse prostate: role of tumor necrosis factor-alpha-stimulated gene 6. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-01, Volume: 12, Issue:3 Pt 1 Topics: 2-Methoxyestradiol; Adenocarcinoma; Animals; Cell Adhesion Molecules; Cell Line, Tumor; Diet; Disease Models, Animal; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms	2006
Distinct tumor stage-specific inhibitory effects of 2-methoxyestradiol in a breast cancer mouse model associated with Id-1 expression. Cancer research, 2006, Apr-01, Volume: 66, Issue:7 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Cell Growth Processes; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Endothelial Cells; Estradiol; Female; Inhibitor of Differentiation Protein 1; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Neoplasm Staging	2006
Antiangiogenic effect of oral 2-methoxyestradiol on choroidal neovascularization in mice. Experimental eye research, 2006, Volume: 83, Issue:5 Topics: 2-Methoxyestradiol; Administration, Oral; Angiogenesis Inhibitors; Animals; Choroid; Choroidal Neovascularization; Disease Models, Animal; Dose-Response Relationship, Drug; Estradiol; Fluorescein Angiography; Image Processing, Computer-Assisted; Laser Coagulation; Macular Degeneration; Male; Mice; Mice, Inbred C57BL	2006
2-methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats. Experimental neurology, 2006, Volume: 202, Issue:2 Topics: 2-Methoxyestradiol; Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Estradiol; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; In Situ Nick-End Labeling; Male; Membrane Proteins; Mitochondrial Proteins; Neurologic Examination; Proliferating Cell Nuclear Antigen; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Subarachnoid Hemorrhage; Time Factors; Tubulin Modulators; Vascular Endothelial Growth Factor A; Vasospasm, Intracranial	2006
Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Cancer research, 2006, Dec-15, Volume: 66, Issue:24 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line, Tumor; Disease Models, Animal; Estradiol; Glioma; Magnetic Resonance Imaging; Rats; Rats, Inbred F344; Tubulin Modulators	2006
Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1alpha and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model. Journal of neurochemistry, 2007, Volume: 102, Issue:6 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Blood-Brain Barrier; Brain Edema; Brain Infarction; Brain Ischemia; Bridged-Ring Compounds; Caspase 3; Cerebral Cortex; Disease Models, Animal; Down-Regulation; Estradiol; Hypoxia-Inducible Factor 1, alpha Subunit; In Situ Nick-End Labeling; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Mitochondrial Proteins; Neuroprotective Agents; Norbornanes; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; Signal Transduction; Thiocarbamates; Thiones; Treatment Outcome; Vascular Endothelial Growth Factor A	2007
The effect of 2-methoxyestradiol, a HIF-1 alpha inhibitor, in global cerebral ischemia in rats. Neurological research, 2008, Volume: 30, Issue:3 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Enzyme Inhibitors; Estradiol; Gene Expression Regulation; Hippocampus; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Rats; Rats, Sprague-Dawley; Time Factors	2008
2-methoxyestradiol inhibits hypoxia-inducible factor-1{alpha} and suppresses growth of lesions in a mouse model of endometriosis. The American journal of pathology, 2008, Volume: 172, Issue:2 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Blotting, Western; Capillary Permeability; Cell Hypoxia; Disease Models, Animal; Endometriosis; Estradiol; Female; Gene Expression; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; Vascular Endothelial Growth Factor A	2008
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. Nature, 2008, Jun-19, Volume: 453, Issue:7198 Topics: 2-Methoxyestradiol; Albumins; Animals; Blood Pressure; Catechol O-Methyltransferase; Creatinine; Disease Models, Animal; Estradiol; Female; Humans; Hypertension; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Killer Cells, Natural; Litter Size; Male; Mice; Placenta; Pre-Eclampsia; Pregnancy; Proteinuria; Vascular Endothelial Growth Factor Receptor-1	2008
Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:3 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Cell Division; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Estradiol; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Metastasis; Neoplasm Transplantation; Pancreatic Neoplasms; Tumor Cells, Cultured	1999
2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer. Biochemical and biophysical research communications, 2001, Aug-03, Volume: 285, Issue:5 Topics: 2-Methoxyestradiol; Administration, Oral; Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Division; Cell Nucleus; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Drug Implants; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Flow Cytometry; G2 Phase; Humans; Male; Mice; Mice, Transgenic; Mitosis; Prostatic Neoplasms; Tumor Cells, Cultured	2001