Page last updated: 2024-08-24

2-methoxyestradiol and Disease Exacerbation

2-methoxyestradiol has been researched along with Disease Exacerbation in 12 studies

Research

Studies (12)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	9 (75.00)	29.6817
2010's	3 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Azab, SS; Elzankalony, YA; Nasr, M; Said, AM; Salah Eldin, RA; Zaki, RG	1
Dobos, J	1
Arnott, J; Bruce, JY; Carducci, M; Eickhoff, J; Liu, G; Logan, T; Pili, R; Treston, A; Wilding, G	1
Anderson, S; Beard, DR; Gattone, VH; Komers, R; Lindsley, JN; Oyama, TT; Schutzer, WE	1
Tímár, J	1
Jackson, EK; Mady, HH; Melhem, MF; Salah, EM; Tofovic, SP	1
Armstrong, V; Fife, K; Horvath, D; Kolesar, J; Liu, G; Sidor, C; Staab, MJ; Sweeney, C; Treston, A; Wilding, G; Yiannoutsos, C	1
Dacic, S; Jackson, EK; Petrusevska, G; Tofovic, SP; Zhang, X	1
Jackson, EK; Jia, Y; Tofovic, SP; Zhang, X	1
Anderson, KC; Dispenzieri, A; Gertz, MA; Greipp, PR; Lacy, MQ; Rajkumar, SV; Richardson, PG; Schlossman, R; Sidor, CF; Witzig, TE	1
Cicek, M; Clohisy, DR; Goblirsch, MJ; Iwaniec, UT; Oursler, MJ; Ruan, M; Turner, RR; Vrabel, A	1
Anderson, C; D'Ippolito, G; Herron, A; Howard, GA; Perez-Stable, CM; Qadan, LR; Roos, BA	1

Trials

3 trial(s) available for 2-methoxyestradiol and Disease Exacerbation

Article	Year
A phase II study of 2-methoxyestradiol nanocrystal colloidal dispersion alone and in combination with sunitinib malate in patients with metastatic renal cell carcinoma progressing on sunitinib malate. Investigational new drugs, 2012, Volume: 30, Issue:2 Topics: 2-Methoxyestradiol; Administration, Oral; Adult; Aged; Aged, 80 and over; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Colloids; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Estradiol; Female; Humans; Indoles; Kidney Neoplasms; Male; Middle Aged; Nanoparticles; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Sunitinib; Survival Analysis; Treatment Failure; United States	2012
A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Sep-15, Volume: 11, Issue:18 Topics: 2-Methoxyestradiol; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents, Hormonal; Area Under Curve; Capsules; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Drug Resistance, Neoplasm; Estradiol; Female; Fibroblast Growth Factor 2; Humans; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Time Factors; Treatment Outcome; Vascular Endothelial Growth Factor A	2005
Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2007, Oct-15, Volume: 13, Issue:20 Topics: 2-Methoxyestradiol; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Disease Progression; Disease-Free Survival; Estradiol; Female; Humans; Male; Middle Aged; Multiple Myeloma; Recurrence; Time Factors; Treatment Outcome; Tubulin Modulators	2007

Other Studies

9 other study(ies) available for 2-methoxyestradiol and Disease Exacerbation

Article	Year
Efficacy of Intravitreal injection of 2-Methoxyestradiol in regression of neovascularization of a retinopathy of prematurity rat model. BMC ophthalmology, 2017, Apr-04, Volume: 17, Issue:1 Topics: 2-Methoxyestradiol; Animals; Animals, Newborn; Disease Models, Animal; Disease Progression; Estradiol; Immunohistochemistry; Intravitreal Injections; Male; Photomicrography; Prospective Studies; Rats; Rats, Sprague-Dawley; Retinal Neovascularization; Retinal Vessels; Retinopathy of Prematurity; Tubulin Modulators; Vascular Endothelial Growth Factor A	2017
[Endocrine factors influencing melanoma progression]. Magyar onkologia, 2009, Volume: 53, Issue:1 Topics: 2-Methoxyestradiol; Animals; Cell Line, Tumor; Disease Models, Animal; Disease Progression; Estradiol; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Gonadal Steroid Hormones; Humans; Male; Melanoma; Mice; Mice, SCID; Receptors, Glucocorticoid; Skin Neoplasms; Tubulin Modulators	2009
2-Hydroxyestradiol slows progression of experimental polycystic kidney disease. American journal of physiology. Renal physiology, 2012, Mar-01, Volume: 302, Issue:5 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Cell Proliferation; Disease Progression; Estradiol; Kidney; Male; Orchiectomy; Polycystic Kidney Diseases; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; TOR Serine-Threonine Kinases; Treatment Outcome	2012
[Report of the National Oncology Research and Developement Consortium, 2003]. Magyar onkologia, 2004, Volume: 48, Issue:1 Topics: 2-Methoxyestradiol; Adult; Animals; Antineoplastic Agents; Biomarkers, Tumor; Biomedical Research; Bone Neoplasms; Breast Neoplasms; Child; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; DNA Methylation; Epoetin Alfa; Erythropoietin; Estradiol; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Markers; Head and Neck Neoplasms; Heparin, Low-Molecular-Weight; Humans; Hungary; Incidence; Male; Melanoma; Microsatellite Repeats; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Polymorphism, Genetic; Predictive Value of Tests; Recombinant Proteins; Transplantation, Heterologous	2004
Estradiol metabolites attenuate monocrotaline-induced pulmonary hypertension in rats. Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:4 Topics: 2-Methoxyestradiol; Animals; Blood Pressure; Body Weight; Cell Proliferation; Disease Progression; Estradiol; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Immunohistochemistry; Lung; Male; Monocrotaline; Proliferating Cell Nuclear Antigen; Rats; Rats, Sprague-Dawley; Time Factors; Tubulin Modulators	2005
2-Methoxyestradiol mediates the protective effects of estradiol in monocrotaline-induced pulmonary hypertension. Vascular pharmacology, 2006, Volume: 45, Issue:6 Topics: 2-Methoxyestradiol; Analysis of Variance; Animals; Blood Pressure; Disease Progression; Estradiol; Female; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy, Right Ventricular; Lung; Monocrotaline; Ovariectomy; Pulmonary Artery; Rats; Time Factors; Ventricular Function, Left; Ventricular Function, Right	2006
2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats. Journal of cardiovascular pharmacology, 2007, Volume: 49, Issue:1 Topics: 2-Methoxyestradiol; Aging; Animals; Diabetes Mellitus; Diabetic Nephropathies; Disease Progression; Estradiol; Male; Obesity; Rats; Tubulin Modulators	2007
2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. Cancer research, 2007, Nov-01, Volume: 67, Issue:21 Topics: 2-Methoxyestradiol; Animals; Bone Neoplasms; Cell Line, Tumor; Disease Progression; Dose-Response Relationship, Drug; Estradiol; Female; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Osteoclasts; Osteolysis	2007
2-Methoxyestradiol induces G2/M arrest and apoptosis in prostate cancer. Biochemical and biophysical research communications, 2001, Aug-03, Volume: 285, Issue:5 Topics: 2-Methoxyestradiol; Administration, Oral; Amino Acid Chloromethyl Ketones; Animals; Annexin A5; Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Cell Division; Cell Nucleus; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Drug Implants; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estradiol; Flow Cytometry; G2 Phase; Humans; Male; Mice; Mice, Transgenic; Mitosis; Prostatic Neoplasms; Tumor Cells, Cultured	2001