Page last updated: 2024-08-24

2-methoxyestradiol and Breast Cancer

2-methoxyestradiol has been researched along with Breast Cancer in 65 studies

Research

Studies (65)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (6.15)	18.2507
2000's	41 (63.08)	29.6817
2010's	16 (24.62)	24.3611
2020's	4 (6.15)	2.80

Authors

Authors	Studies
Agoston, GE; Lavallee, TM; Pribluda, VS; Shah, JH; Treston, AM; Zhan, X	1
Potter, BV; Thomas, MP	1
Choromanska, A; Kulbacka, J; Saczko, J; Waszkiewicz, M	1
Dohle, W; Hargrave, SD; Joubert, AM; Marais, S; Mercier, AE; Potter, BVL	1
Joubert, AM; Lafanechère, L; Mercier, AE; Nolte, EM	1
Cheng, KG; Li, L; Sheng, LX; Wen, XA; Xie, X; Zhang, JY	1
Chen, W; Huo, P; Liu, X; Tian, Q; Wang, P; Xu, H; Xu, Y; Zhang, J; Zhang, N	1
Hersi, F; Noreddin, AM; Nunes, ACF; Omar, HA; Tolba, MF	1
Li, L; Ma, R; Shi, J; Wang, H; Wang, L; Wang, Z; Yu, X; Zhang, J; Zhang, Z	1
Chen, H; Guo, X; Li, S; Xing, Y	1
Bar, J; Bednarz-Misa, I; Choromańska, A; Dubińska-Magiera, M; Kulbacka, J; Marcinkowska, A; Rembiałkowska, N; Saczko, J	1
Fecková, B; Ilkovičová, L; Kello, M; Kimáková, P; Sačková, V; Solár, P; Solárová, Z	1
Barone, G; Gorska-Ponikowska, M; Kuban-Jankowska, A; Lo Bosco, G; Perricone, U	1
Fukui, M; Zhu, BT	1
Chander, SK; Foster, PA; Jhalli, R; Leese, MP; Newman, SP; Parsons, MF; Potter, BV; Purohit, A; Reed, MJ	1
Amagai, T; Kuruto, R; Ohura, T; Sakakibara, H; Shimoi, K; Takemura, H; Uchiyama, H	1
Joubert, A; Laurens, J; Lottering, ML; Van Zyl, H	1
Joubert, AM; Marais, S; Stander, BA; Vorster, CJ	1
Mueck, AO; Seeger, H	1
Hu, G; Kang, Y; Lu, X; Wei, Y; Yan, CH; Yuan, M	1
Cho, JK; Hong, KY; Park, JW; Song, SC; Yang, HK	1
Botting, S; Diaz-Arrastia, C; Hatch, S; Patel, D; Salama, S	1
Aranda, E; Bravo, ML; Brosens, JJ; Cuello, MA; Diaz, J; Henriquez, S; Kato, S; Lange, CA; Oliva, B; Owen, GI; Quezada, M; Villalon, M	1
Choi, HJ; Zhu, BT	1
Blaukat, A; Bu, S; Fu, X; Heldin, NE; Landström, M	1
Green, SJ; Hembrough, WA; Herbstritt, CJ; Johnson, MS; LaVallee, TM; Pribluda, VS; Swartz, G; Williams, MS; Zhan, XH	1
Figg, WD; Lakhani, NJ; Sarkar, MA; Venitz, J	1
Cessac, JW; Leal, RM; Mooberry, SL; Randall-Hlubek, DA; Rao, PN; Tinley, TL; Wilkens, LR	1
Diesing, D; Gückel, B; Huober, J; Mueck, AO; Seeger, H; Wallwiener, D	1
Leese, MP; Newman, SP; Potter, BV; Purohit, A; Reed, MJ; Suzuki, RN	1
Escuin, D; Giannakakou, P; Johnson, MS; LaVallee, TM; Mabjeesh, NJ; Pribluda, VS; Simons, JW; Swartz, GM; Willard, MT; Zhong, H	1
Sanderson, JT; van den Berg, M; van der Bruggen, M; van der Linden, J; van Duursen, MB	1
Lippert, TH; Mueck, AO; Seeger, H	1
Chander, SK; Ireson, CR; Leese, MP; Newman, SP; Parish, D; Perera, S; Potter, BV; Purohit, A; Reed, MJ; Smith, AC	1
Tímár, J	1
Liu, ZJ; Zhu, BT	1
Huober, J; Mueck, AO; Seeger, H	1
Leese, MP; Mouzakiti, A; Packham, G; Potter, BV; Purohit, A; Reed, MJ; Wood, L	1
Albanese, C; Gallo, MA; Lewis, JS; Pestell, RG; Thomas, T; Thomas, TJ	1
Han, GZ; Liu, ZJ; Shimoi, K; Zhu, BT	1
Anderson, RL; Eckhardt, BL; Harris, T; Quan, L; Schuliga, M; Stewart, AG; Sutherland, TE	1
Leese, MP; Potter, BV; Purohit, A; Raobaikady, B; Reed, MJ	1
Lee, WJ; Liu, ZJ; Zhu, BT	1
D'Amato, R; Miller, KD; Sidor, C	1
Escuin, D; Giannakakou, P; Gökmen-Polar, Y; Guenther, BD; Lavallee, TM; Sanders, KL; Sledge, GW; Soule, SE; Walls, CD; Wang, M; Wang, Y	1
Mueck, AO; Seeger, H; Wallwiener, D	1
Day, JM; Ireson, CR; Leese, MP; Newman, SP; Parsons, MF; Potter, BV; Purohit, A; Reed, MJ; Tutill, HJ	1
Nair, SK; Thomas, T; Thomas, TJ; Venkiteswaran, S; Verma, A; Vijayanathan, V; Zhu, BT	1
James, J; Miller, KD; Murry, DJ; Sidor, C; Sledge, GW; Storniolo, AM; Treston, AM	1
Jordan, MA; Kamath, K; Larson, G; Okouneva, T; Panda, D; Wilson, L	1
Chou, TC; Gallo, MA; Nair, SK; Shirahata, A; Thomas, T; Thomas, TJ; Verma, A	1
Bhati, R; Borchers, CH; Dial, MJ; Fan, C; Gökmen-Polar, Y; Ketelsen, D; Klauber-DeMore, N; Nakshatri, H; Patterson, C; Sledge, GW	1
Chander, SK; Foster, PA; Leese, MP; Newman, SP; Potter, BV; Purohit, A; Reed, MJ	1
Day, JM; Foster, PA; Ho, YT; Judde, JG; Lassalle, M; Leese, MP; Newman, SP; Potter, BV; Prevost, G; Purohit, A; Reed, MJ; Stengel, C	1
Abdel-Naim, AB; Al-Hendy, A; Azab, SS; El-Demerdash, E; Khalifa, AE; Salama, SA	1
Abdel-Naim, AB; Al-Hendy, A; Azab, SS; El-Demerdash, E; Fouad, H; Hassan, MH; Khalifa, AE; Salama, SA	1
D'Amato, RJ; Flynn, E; Hamel, E; Klauber, N; Parangi, S	1
Conney, AH; Zhu, BT	1
Banerjee, SK; Campbell, DR; Johnson, DC; Weston, AP; Zoubine, MN	1
Hejaz, HA; Potter, BV; Purohit, A; Reed, MJ; Singh, A	1
Aldous, KM; Connor, SP; Gierthy, JF; Hussain, MM; Katz, BH; Pang, S; Spink, BC; Spink, DC	1
Purohit, A; Reed, MJ	1
Bhat, AS; Brueggemeier, RW; Burak, WE; Coughenour, HD; Joomprabutra, S; Lovely, CJ; Vandre, DD; Weitzel, DH; Yusuf, F	1
Green, SJ; Herbstritt, CJ; Kough, EC; LaVallee, TM; Pribluda, VS; Zhan, XH	1
Haag, M; Lottering, ML; Seegers, JC	1

Reviews

6 review(s) available for 2-methoxyestradiol and Breast Cancer

Article	Year
C2- and C4-position 17beta-estradiol metabolites and their relation to breast cancer. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al, 2009, Volume: 33, Issue:3 Topics: 2-Methoxyestradiol; Animals; Breast Neoplasms; Cell Proliferation; Estradiol; Estrogens, Catechol; Humans	2009
2-Methoxyestradiol--biology and mechanism of action. Steroids, 2010, Volume: 75, Issue:10 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line; Cell Proliferation; Estradiol; Female; Humans; Male; Models, Biological; Prostatic Neoplasms	2010
2-Methoxyestradiol, a promising anticancer agent. Pharmacotherapy, 2003, Volume: 23, Issue:2 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Breast Neoplasms; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Double-Blind Method; Estradiol; Female; Humans; Male; Prostatic Neoplasms; Randomized Controlled Trials as Topic	2003
[Estrogen-dependent neoplasia - what is the significance of estradiol metabolites]. Zentralblatt fur Gynakologie, 2003, Volume: 125, Issue:11 Topics: 2-Methoxyestradiol; Anticarcinogenic Agents; Breast Neoplasms; Estradiol; Estrogens, Catechol; Female; Humans; Hydroxyestrones; Male; Neovascularization, Pathologic; Neovascularization, Physiologic; Postmenopause; Prostatic Neoplasms	2003
Is 2-methoxyestradiol an endogenous estrogen metabolite that inhibits mammary carcinogenesis? Cancer research, 1998, Jun-01, Volume: 58, Issue:11 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Transformation, Neoplastic; Estradiol; Female; Humans; Mammary Neoplasms, Experimental; Neovascularization, Pathologic; Tumor Cells, Cultured	1998
Aromatase regulation and breast cancer. Clinical endocrinology, 2001, Volume: 54, Issue:5 Topics: 2-Methoxyestradiol; Adult; Animals; Aromatase; Aromatase Inhibitors; Aryl Hydrocarbon Hydroxylases; Breast; Breast Neoplasms; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Cytokines; Dietary Fats; Dinoprostone; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogens; Female; Fibroblasts; Humans; Letrozole; Middle Aged; Nitriles; Obesity; Pesticides; Steroid 16-alpha-Hydroxylase; Steroid Hydroxylases; Triazoles	2001

Trials

1 trial(s) available for 2-methoxyestradiol and Breast Cancer

Article	Year
Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer. Investigational new drugs, 2007, Volume: 25, Issue:1 Topics: 2-Methoxyestradiol; Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Estradiol; Fatigue; Female; Half-Life; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Taxoids; Treatment Outcome; Tubulin Modulators; Urinalysis; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A	2007

Article

Year

Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer.

Investigational new drugs, 2007, Volume: 25, Issue:1

Topics: 2-Methoxyestradiol; Administration, Oral; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Estradiol; Fatigue; Female; Half-Life; Humans; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Taxoids; Treatment Outcome; Tubulin Modulators; Urinalysis; Vascular Cell Adhesion Molecule-1; Vascular Endothelial Growth Factor A

2007

Other Studies

58 other study(ies) available for 2-methoxyestradiol and Breast Cancer

Article	Year
Synthesis and structure-activity relationships of 16-modified analogs of 2-methoxyestradiol. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Drug Screening Assays, Antitumor; Estradiol; Female; Humans; Molecular Structure; Structure-Activity Relationship	2007
Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women's Health. Journal of medicinal chemistry, 2015, Oct-08, Volume: 58, Issue:19 Topics: Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Discovery; Endometriosis; Estrone; Female; Humans; Male; Molecular Targeted Therapy; Prostatic Neoplasms; Steryl-Sulfatase; Sulfonic Acids; Tubulin Modulators	2015
The photodynamic reaction with IR-775 cyanine combined with 2-methoxyestradiol in ovarian (SKOV-3) and human breast adenocarcinoma (MDA MB-231) cell lines. Photodiagnosis and photodynamic therapy, 2022, Volume: 38 Topics: 2-Methoxyestradiol; Adenocarcinoma; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Humans; Mercaptoethanol; Ovary; Photochemotherapy; Photosensitizing Agents	2022
Cell Fate following Irradiation of MDA-MB-231 and MCF-7 Breast Cancer Cells Pre-Exposed to the Tetrahydroisoquinoline Sulfamate Microtubule Disruptor STX3451. Molecules (Basel, Switzerland), 2022, Jun-14, Volume: 27, Issue:12 Topics: 2-Methoxyestradiol; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Microtubules; Sulfonic Acids; Tetrahydroisoquinolines	2022
Radiosensitization of Breast Cancer Cells with a 2-Methoxyestradiol Analogue Affects DNA Damage and Repair Signaling In Vitro. International journal of molecular sciences, 2023, Feb-10, Volume: 24, Issue:4 Topics: 2-Methoxyestradiol; Apoptosis; Breast Neoplasms; Cell Line, Tumor; DNA Damage; DNA Repair; Estrenes; Female; Humans; Sulfonamides	2023
Design, Synthesis, and Evaluation of Novel 2-Methoxyestradiol Derivatives as Apoptotic Inducers Through an Intrinsic Apoptosis Pathway. Biomolecules, 2020, 01-10, Volume: 10, Issue:1 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line; Cell Line, Tumor; Female; Humans; MCF-7 Cells; Models, Molecular	2020
Investigation of an antitumor drug-delivery system based on anti-HER2 antibody-conjugated BSA nanoparticles. Anti-cancer drugs, 2018, Volume: 29, Issue:4 Topics: 2-Methoxyestradiol; Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Cell Cycle Checkpoints; Cell Line, Tumor; Drug Delivery Systems; Female; Humans; Immunoconjugates; Male; Mice; Nanoparticles; Rats; Receptor, ErbB-2; Serum Albumin, Bovine	2018
The impact of Catechol-O-methyl transferase knockdown on the cell proliferation of hormone-responsive cancers. Molecular and cellular endocrinology, 2019, 05-15, Volume: 488 Topics: 2-Methoxyestradiol; Aromatase; Breast Neoplasms; Catechol O-Methyltransferase; Catechols; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Docetaxel; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Hormones; Humans; Male; Nitriles; Phosphorylation; Prostatic Neoplasms; Receptors, Estrogen; RNA, Small Interfering; Transcription Factor RelA	2019
Photodynamic therapy of a 2-methoxyestradiol tumor-targeting drug delivery system mediated by Asn-Gly-Arg in breast cancer. International journal of nanomedicine, 2013, Volume: 8 Topics: 2-Methoxyestradiol; Animals; Apoptosis; Breast Neoplasms; Cell Proliferation; Cell Survival; DNA Fragmentation; Drug Carriers; Estradiol; Female; Fullerenes; Humans; Malonates; MCF-7 Cells; Mice; Oligopeptides; Photochemotherapy; Photosensitizing Agents; Reactive Oxygen Species	2013
In vitro and in vivo investigation of a novel two-phase delivery system of 2-methoxyestradiol liposomes hydrogel. Journal of liposome research, 2014, Volume: 24, Issue:1 Topics: 2-Methoxyestradiol; Animals; Breast Neoplasms; Cell Line, Tumor; Drug Delivery Systems; Estradiol; Female; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogels; Liposomes; Mice; Microscopy, Electron, Scanning; Particle Size; Polyethylene Glycols; Polyglactin 910; Rheology; Temperature; Thermosensing	2014
Oxidative modification induced by photodynamic therapy with Photofrin®II and 2-methoxyestradiol in human ovarian clear carcinoma (OvBH-1) and human breast adenocarcinoma (MCF-7) cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2015, Volume: 71 Topics: 2-Methoxyestradiol; Adenocarcinoma; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cytoskeleton; Dihematoporphyrin Ether; Estradiol; Female; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Nitric Oxide Synthase Type II; Ovarian Neoplasms; Oxidation-Reduction; Photochemotherapy	2015
Photoactivated hypericin increases the expression of SOD-2 and makes MCF-7 cells resistant to photodynamic therapy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 85 Topics: 2-Methoxyestradiol; Adenocarcinoma; Anthracenes; Breast Neoplasms; Cell Line, Tumor; Estradiol; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Light; Perylene; Photochemotherapy; Photosensitizing Agents; RNA, Messenger; Superoxide Dismutase; Up-Regulation	2017
2-methoxyestradiol impacts on amino acids-mediated metabolic reprogramming in osteosarcoma cells by its interaction with NMDA receptor. Journal of cellular physiology, 2017, Volume: 232, Issue:11 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Binding Sites; Bone Neoplasms; Breast Neoplasms; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Energy Metabolism; Estradiol; Female; Glycine; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Molecular Docking Simulation; Molecular Dynamics Simulation; Nerve Tissue Proteins; Nitric Oxide Synthase Type I; Osteosarcoma; Protein Binding; Protein Domains; Receptors, N-Methyl-D-Aspartate; Serine; Signal Transduction; Structure-Activity Relationship; Time Factors; Tubulin Modulators	2017
Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells. Molecular carcinogenesis, 2009, Volume: 48, Issue:1 Topics: 2-Methoxyestradiol; Apoptosis; Apoptosis Regulatory Proteins; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cyclooxygenase 2 Inhibitors; Enzyme-Linked Immunosorbent Assay; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Humans; JNK Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Signal Transduction; Tubulin Modulators; Tumor Cells, Cultured	2009
The in vivo properties of STX243: a potent angiogenesis inhibitor in breast cancer. British journal of cancer, 2008, Nov-04, Volume: 99, Issue:9 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Breast Neoplasms; Cell Line, Tumor; Estradiol; Estrenes; Female; Humans; Mice; Mice, Inbred C57BL; Rats; Rats, Wistar; Sulfonic Acids	2008
A methoxyflavonoid, chrysoeriol, selectively inhibits the formation of a carcinogenic estrogen metabolite in MCF-7 breast cancer cells. The Journal of steroid biochemistry and molecular biology, 2010, Volume: 118, Issue:1-2 Topics: 2-Methoxyestradiol; Aryl Hydrocarbon Hydroxylases; Biocatalysis; Breast Neoplasms; Carcinogens; Catechol O-Methyltransferase; Cell Line, Tumor; Chemoprevention; Culture Media, Conditioned; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytosol; Enzyme Inhibitors; Estradiol; Estrogens, Catechol; Female; Flavones; Flavonoids; Gene Expression; Glucuronidase; Humans; Hydroxylation; Kinetics; Methylation; Oxazines; Recombinant Proteins; Sulfatases	2010
In vitro effects of 2-methoxyestradiol on morphology, cell cycle progression, cell death and gene expression changes in the tumorigenic MCF-7 breast epithelial cell line. The Journal of steroid biochemistry and molecular biology, 2010, Volume: 119, Issue:3-5 Topics: 2-Methoxyestradiol; Adenocarcinoma; Antineoplastic Agents; Apoptosis; Autophagy; Breast Neoplasms; Caspase 3; Cell Cycle; Cell Death; Cell Line, Tumor; Cell Shape; Cyclin B1; Cytochromes c; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Oligonucleotide Array Sequence Analysis; Reactive Oxygen Species; Receptors, Estrogen; Vacuoles	2010
In vivo dynamics and distinct functions of hypoxia in primary tumor growth and organotropic metastasis of breast cancer. Cancer research, 2010, May-15, Volume: 70, Issue:10 Topics: 2-Methoxyestradiol; Animals; Biomarkers, Tumor; Bone Neoplasms; Breast Neoplasms; Estradiol; Female; Gene Expression Profiling; Genes, Dominant; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Lung Neoplasms; Mice; Neovascularization, Pathologic; Oligonucleotide Array Sequence Analysis; Prognosis; Survival Rate; Tubulin Modulators; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2010
Injectable delivery system of 2-methoxyestradiol for breast cancer therapy using biodegradable thermosensitive poly(organophosphazene) hydrogel. Journal of drug targeting, 2011, Volume: 19, Issue:4 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Breast Neoplasms; Drug Carriers; Estradiol; Female; Humans; Hydrogels; Immunohistochemistry; Mice; Neoplasms, Experimental; Organophosphorus Compounds; Platelet Endothelial Cell Adhesion Molecule-1; Polymers; Rheology; Solubility	2011
2-Methoxyestradiol, an endogenous estrogen metabolite, sensitizes radioresistant MCF-7/FIR breast cancer cells through multiple mechanisms. International journal of radiation oncology, biology, physics, 2011, May-01, Volume: 80, Issue:1 Topics: 2-Methoxyestradiol; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Proliferation; DNA Damage; Estradiol; Female; Gamma Rays; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Neoplasm Proteins; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Radiation Tolerance; Radiation-Sensitizing Agents; Reactive Oxygen Species; Signal Transduction; Tumor Stem Cell Assay	2011
2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. Hormones & cancer, 2010, Volume: 1, Issue:3 Topics: 2-Methoxyestradiol; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Signaling System; Progesterone; Reverse Transcriptase Polymerase Chain Reaction; Thromboplastin; Transcriptional Activation; Transfection; Tubulin Modulators	2010
Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. Biochimica et biophysica acta, 2012, Volume: 1823, Issue:8 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Breast Neoplasms; Calcium-Binding Proteins; CDC2 Protein Kinase; Cell Cycle Proteins; Cell Line, Tumor; Cell Nucleus Shape; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; Estradiol; Female; G2 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; Humans; Mad2 Proteins; Mitogen-Activated Protein Kinase 8; Prometaphase; Repressor Proteins; RNA Interference; Up-Regulation	2012
Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells. FEBS letters, 2002, Nov-06, Volume: 531, Issue:2 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Apoptosis; Breast; Breast Neoplasms; Carcinoma; Caspases; Cell Division; Colonic Neoplasms; Endothelium; Estradiol; Female; Humans; Kinetics; Liver Neoplasms; Male; Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Prostatic Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred F344; Tumor Cells, Cultured	2002
2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway. Cancer research, 2003, Jan-15, Volume: 63, Issue:2 Topics: 2-Methoxyestradiol; Adaptor Proteins, Signal Transducing; Animals; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Carrier Proteins; Caspases; Cell Division; Drug Synergism; Endothelium, Vascular; Enzyme Activation; Estradiol; Fas-Associated Death Domain Protein; Female; Humans; Isoenzymes; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mice, Nude; Receptors, TNF-Related Apoptosis-Inducing Ligand; Receptors, Tumor Necrosis Factor; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation; Xenograft Model Antitumor Assays	2003
Novel 2-methoxyestradiol analogues with antitumor activity. Cancer research, 2003, Apr-01, Volume: 63, Issue:7 Topics: 2-Methoxyestradiol; Animals; Breast Neoplasms; Caspase 3; Caspases; Cell Division; Cell Nucleus; Drug Screening Assays, Antitumor; Endothelium, Vascular; Enzyme Activation; Estradiol; Female; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Microtubules; Rats; Spindle Apparatus; Tubulin; Tubulin Modulators; Xenograft Model Antitumor Assays	2003
Effect of tamoxifen and 2-methoxyestradiol alone and in combination on human breast cancer cell proliferation. The Journal of steroid biochemistry and molecular biology, 2003, Volume: 84, Issue:2-3 Topics: 2-Methoxyestradiol; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Estradiol; Humans; Inhibitory Concentration 50; Receptors, Estrogen; Tamoxifen; Tumor Cells, Cultured	2003
Growth inhibition of multi-drug-resistant breast cancer cells by 2-methoxyoestradiol-bis-sulphamate and 2-ethyloestradiol-bis-sulphamate. The Journal of steroid biochemistry and molecular biology, 2003, Volume: 84, Issue:2-3 Topics: 2-Methoxyestradiol; Biocompatible Materials; Breast Neoplasms; Cell Cycle; Cell Division; Collagen; Drug Combinations; Estradiol; Estriol; G2 Phase; Humans; Laminin; Mitosis; Models, Chemical; Plastics; Proteoglycans; Sulfonic Acids; Tumor Cells, Cultured	2003
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer cell, 2003, Volume: 3, Issue:4 Topics: 2-Methoxyestradiol; Animals; Blotting, Northern; Breast Neoplasms; DNA-Binding Proteins; Endothelial Growth Factors; Estradiol; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Lymphokines; Mice; Microscopy, Confocal; Microtubules; Models, Animal; Neovascularization, Pathologic; Nuclear Proteins; RNA, Messenger; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
Effects of several dioxin-like compounds on estrogen metabolism in the malignant MCF-7 and nontumorigenic MCF-10A human mammary epithelial cell lines. Toxicology and applied pharmacology, 2003, Aug-01, Volume: 190, Issue:3 Topics: 2-Methoxyestradiol; Aryl Hydrocarbon Hydroxylases; Benzofurans; Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Line; Cell Survival; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1B1; Dioxins; Dose-Response Relationship, Drug; Epithelial Cells; Estradiol; Female; Humans; Polychlorinated Biphenyls; Polychlorinated Dibenzodioxins	2003
Pharmacokinetics and efficacy of 2-methoxyoestradiol and 2-methoxyoestradiol-bis-sulphamate in vivo in rodents. British journal of cancer, 2004, Feb-23, Volume: 90, Issue:4 Topics: 2-Methoxyestradiol; Administration, Oral; Animals; Biological Availability; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estriol; Female; Melanoma; Mice; Mice, Nude; Rats; Skin Neoplasms; Transplantation, Heterologous	2004
[Report of the National Oncology Research and Developement Consortium, 2003]. Magyar onkologia, 2004, Volume: 48, Issue:1 Topics: 2-Methoxyestradiol; Adult; Animals; Antineoplastic Agents; Biomarkers, Tumor; Biomedical Research; Bone Neoplasms; Breast Neoplasms; Child; Colorectal Neoplasms; Disease Models, Animal; Disease Progression; DNA Methylation; Epoetin Alfa; Erythropoietin; Estradiol; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genetic Markers; Head and Neck Neoplasms; Heparin, Low-Molecular-Weight; Humans; Hungary; Incidence; Male; Melanoma; Microsatellite Repeats; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Polymorphism, Genetic; Predictive Value of Tests; Recombinant Proteins; Transplantation, Heterologous	2004
Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells. The Journal of steroid biochemistry and molecular biology, 2004, Volume: 88, Issue:3 Topics: 2-Methoxyestradiol; Breast Neoplasms; Cell Division; Cell Line, Tumor; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Humans; Mitogens; Receptors, Estrogen	2004
Chemotherapy of breast cancer-additive anticancerogenic effects by 2-methoxyestradiol? Life sciences, 2004, Jul-23, Volume: 75, Issue:10 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Synergism; Estradiol; Female; Humans	2004
2-MeOE2bisMATE induces caspase-dependent apoptosis in CAL51 breast cancer cells and overcomes resistance to TRAIL via cooperative activation of caspases. Apoptosis : an international journal on programmed cell death, 2004, Volume: 9, Issue:3 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Biological Availability; Breast Neoplasms; Caspases; Cell Line, Tumor; Cell Survival; Enzyme Activation; Epithelial Cells; Estradiol; Humans; Membrane Glycoproteins; Molecular Structure; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha	2004
Differential effects of 16alpha-hydroxyestrone and 2-methoxyestradiol on cyclin D1 involving the transcription factor ATF-2 in MCF-7 breast cancer cells. Journal of molecular endocrinology, 2005, Volume: 34, Issue:1 Topics: 2-Methoxyestradiol; Activating Transcription Factor 2; Blotting, Western; Breast Neoplasms; Cyclic AMP Response Element-Binding Protein; Cyclin D1; DNA Replication; Enzyme Activation; Estradiol; Female; Gene Expression Regulation, Neoplastic; Humans; Hydroxyestrones; p38 Mitogen-Activated Protein Kinases; Transcription Factors	2005
Synergism between the anticancer actions of 2-methoxyestradiol and microtubule-disrupting agents in human breast cancer. Cancer research, 2005, Jan-15, Volume: 65, Issue:2 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Doxorubicin; Drug Synergism; Estradiol; Female; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Paclitaxel; Vinblastine; Vinorelbine; Xenograft Model Antitumor Assays	2005
2-methoxyestradiol is an estrogen receptor agonist that supports tumor growth in murine xenograft models of breast cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Mar-01, Volume: 11, Issue:5 Topics: 2-Methoxyestradiol; Animals; Breast Neoplasms; Cell Proliferation; Disease Models, Animal; Estradiol; Female; Gene Expression Profiling; Humans; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Receptors, Estrogen; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous; Tumor Cells, Cultured	2005
Inhibition of MDA-MB-231 cell cycle progression and cell proliferation by C-2-substituted oestradiol mono- and bis-3-O-sulphamates. International journal of cancer, 2005, Oct-20, Volume: 117, Issue:1 Topics: 2-Methoxyestradiol; Breast Neoplasms; Cell Division; Cell Proliferation; Collagen; Drug Combinations; Estradiol; Estrogen Receptor alpha; Female; G2 Phase; Humans; Laminin; Phosphorylation; Proteoglycans; Proto-Oncogene Proteins c-bcl-2; Sulfonic Acids; Tumor Cells, Cultured; Tumor Stem Cell Assay	2005
Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause. Cancer research, 2005, Jul-01, Volume: 65, Issue:13 Topics: 17-Hydroxysteroid Dehydrogenases; 2-Methoxyestradiol; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Estradiol; Estradiol Dehydrogenases; Estrogens; Humans; Hydroxysteroids; Isoenzymes; Ketosteroids; Kinetics; Reverse Transcriptase Polymerase Chain Reaction; Spironolactone	2005
The potential and suitability of 2-methoxyestradiol in cancer therapy. Clinical cancer research : an official journal of the American Association for Cancer Research, 2005, Aug-15, Volume: 11, Issue:16 Topics: 2-Methoxyestradiol; Animals; Breast Neoplasms; Cell Line, Tumor; Estradiol; Female; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Treatment Outcome; Xenograft Model Antitumor Assays	2005
beta-Tubulin mutations are associated with resistance to 2-methoxyestradiol in MDA-MB-435 cancer cells. Cancer research, 2005, Oct-15, Volume: 65, Issue:20 Topics: 2-Methoxyestradiol; Amino Acid Sequence; Breast Neoplasms; Cell Line, Tumor; DNA, Neoplasm; Drug Resistance, Neoplasm; Estradiol; Humans; Mass Spectrometry; Microtubules; Models, Molecular; Molecular Sequence Data; Point Mutation; Protein Isoforms; Structure-Activity Relationship; Tubulin; Tubulin Modulators	2005
Different effects of estradiol and various antiestrogens on TNF-alpha-induced changes of biochemical markers for growth and invasion of human breast cancer cells. Life sciences, 2006, Feb-23, Volume: 78, Issue:13 Topics: 2-Methoxyestradiol; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Division; Cell Line, Tumor; Estradiol; Estrogen Receptor Modulators; Female; Humans; Interleukin-8; Neoplasm Invasiveness; Tamoxifen; Tumor Necrosis Factor-alpha	2006
The role of 17beta-hydroxysteroid dehydrogenases in modulating the activity of 2-methoxyestradiol in breast cancer cells. Cancer research, 2006, Jan-01, Volume: 66, Issue:1 Topics: 17-Hydroxysteroid Dehydrogenases; 2-Methoxyestradiol; Biotransformation; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Estradiol; Humans; Stereoisomerism; Transfection	2006
Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Apr-01, Volume: 12, Issue:7 Pt 1 Topics: 2-Methoxyestradiol; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Female; Humans; Phosphorylation; Polyamines; Signal Transduction; Structure-Activity Relationship; Time Factors; Tumor Cells, Cultured	2006
2-Methoxyestradiol suppresses microtubule dynamics and arrests mitosis without depolymerizing microtubules. Molecular cancer therapeutics, 2006, Volume: 5, Issue:9 Topics: 2-Methoxyestradiol; Angiogenesis Inhibitors; Animals; Antimitotic Agents; Breast Neoplasms; Cattle; Cell Line, Tumor; Estradiol; Humans; Interphase; Mice; Microtubules; Mitosis; Spindle Apparatus; Strongylocentrotus purpuratus; Tubulin; Tubulin Modulators	2006
Synergistic apoptosis of MCF-7 breast cancer cells by 2-methoxyestradiol and bis(ethyl)norspermine. Cancer letters, 2007, Jun-08, Volume: 250, Issue:2 Topics: 2-Methoxyestradiol; Apoptosis; Blotting, Western; Breast Neoplasms; Bromodeoxyuridine; Cell Cycle; Cell Line, Tumor; Cell Nucleus; Cyclin D1; Drug Synergism; Estradiol; Humans; Microscopy, Confocal; Phosphorylation; Proto-Oncogene Proteins c-akt; Spermine	2007
2-methoxyestradiol inhibits the anaphase-promoting complex and protein translation in human breast cancer cells. Cancer research, 2007, Jan-15, Volume: 67, Issue:2 Topics: 2-Methoxyestradiol; Anaphase-Promoting Complex-Cyclosome; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Growth Processes; Cell Line, Tumor; Estradiol; Humans; Mutation; Oligonucleotide Array Sequence Analysis; Protein Biosynthesis; Tubulin; Tubulin Modulators; Ubiquitin-Protein Ligase Complexes	2007
In vivo inhibition of angiogenesis by sulphamoylated derivatives of 2-methoxyoestradiol. British journal of cancer, 2007, May-07, Volume: 96, Issue:9 Topics: 2-Methoxyestradiol; Animals; Breast Neoplasms; Cell Division; Cell Line, Tumor; Collagen; Drug Combinations; Estradiol; Female; Humans; Laminin; Mice; Mice, Nude; Neovascularization, Pathologic; Proteoglycans; Transplantation, Heterologous; Tubulin Modulators	2007
STX140 is efficacious in vitro and in vivo in taxane-resistant breast carcinoma cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2008, Jan-15, Volume: 14, Issue:2 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm; Estradiol; Estrenes; Humans; Mice; Mice, Nude; Paclitaxel; Tubulin Modulators; Xenograft Model Antitumor Assays	2008
2-Methoxyestradiol and multidrug resistance: can 2-methoxyestradiol chemosensitize resistant breast cancer cells? Breast cancer research and treatment, 2009, Volume: 113, Issue:1 Topics: 2-Methoxyestradiol; Breast Neoplasms; Caspase 3; Cell Cycle; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Estradiol; Female; Flow Cytometry; Humans; Polymerase Chain Reaction; Rhodamine 123; RNA, Neoplasm	2009
2-Methoxyestradiol reverses doxorubicin resistance in human breast tumor xenograft. Cancer chemotherapy and pharmacology, 2008, Volume: 62, Issue:5 Topics: 2-Methoxyestradiol; Algorithms; Angiogenesis Inhibitors; Animals; Antibiotics, Antineoplastic; Apoptosis; Body Weight; Breast Neoplasms; Cell Proliferation; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Estradiol; Female; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Liver; Mice; Mice, Inbred BALB C; Mice, Nude; Myocardium; Xenograft Model Antitumor Assays	2008
Inhibition of angiogenesis and breast cancer in mice by the microtubule inhibitors 2-methoxyestradiol and taxol. Cancer research, 1997, Jan-01, Volume: 57, Issue:1 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Corneal Neovascularization; Estradiol; Humans; Mice; Mice, Inbred C57BL; Mice, SCID; Neoplasm Transplantation; Paclitaxel; Tumor Stem Cell Assay	1997
2-methoxyestradiol-induced growth suppression and lethality in estrogen-responsive MCF-7 cells may be mediated by down regulation of p34cdc2 and cyclin B1 expression. International journal of oncology, 1999, Volume: 15, Issue:4 Topics: 2-Methoxyestradiol; Apoptosis; Breast Neoplasms; CDC2 Protein Kinase; Cell Division; Cell Survival; Cyclin B; Cyclin B1; Dose-Response Relationship, Drug; Down-Regulation; Estradiol; Gene Expression Regulation, Neoplastic; Humans; In Situ Nick-End Labeling; Time Factors; Tumor Cells, Cultured	1999
Inhibition of deoxyglucose uptake in MCF-7 breast cancer cells by 2-methoxyestrone and 2-methoxyestrone-3-O-sulfamate. Molecular and cellular endocrinology, 2000, Feb-25, Volume: 160, Issue:1-2 Topics: 2-Methoxyestradiol; Antineoplastic Agents; Biological Transport, Active; Breast Neoplasms; Deoxyglucose; Estradiol; Estrone; Female; Humans; Hydroxyestrones; Insulin; Kinetics; Paclitaxel; Tumor Cells, Cultured	2000
SULT1A1 catalyzes 2-methoxyestradiol sulfonation in MCF-7 breast cancer cells. Carcinogenesis, 2000, Volume: 21, Issue:11 Topics: 2-Methoxyestradiol; Animals; Arylsulfotransferase; Baculoviridae; Breast; Breast Neoplasms; Catalysis; Cells, Cultured; Cloning, Molecular; DNA, Complementary; Epithelial Cells; Estradiol; Gene Amplification; Humans; Isoenzymes; Kinetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spodoptera; Sulfates; Sulfotransferases; Tumor Cells, Cultured	2000
2-Methoxymethylestradiol: a new 2-methoxy estrogen analog that exhibits antiproliferative activity and alters tubulin dynamics. The Journal of steroid biochemistry and molecular biology, 2001, Volume: 78, Issue:2 Topics: 2-Methoxyestradiol; Animals; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrogens; Female; Humans; Mice; Mice, Nude; Protein Biosynthesis; Proteins; Receptors, Estrogen; Trefoil Factor-1; Tubulin; Tumor Cells, Cultured; Tumor Suppressor Proteins	2001
2-Methoxyestradiol inhibits proliferation and induces apoptosis independently of estrogen receptors alpha and beta. Cancer research, 2002, Jul-01, Volume: 62, Issue:13 Topics: 2-Methoxyestradiol; Apoptosis; Breast Neoplasms; Cell Division; Cytochrome P-450 Enzyme Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Flavonoids; Fulvestrant; Humans; Receptors, Estrogen; Tumor Cells, Cultured	2002
Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells. Cancer research, 1992, Nov-01, Volume: 52, Issue:21 Topics: 2-Methoxyestradiol; Breast Neoplasms; Cell Cycle; Cyclic AMP; DNA, Neoplasm; Estradiol; G2 Phase; Humans; Methionine; Mitosis; Molecular Weight; Neoplasm Proteins; Phosphorylation; S Phase; Time Factors; Tumor Cells, Cultured	1992