2-mercapto-5-benzimidazolesulfonic-acid and Liver-Neoplasms

In this study, we have developed a facile, rapid one-pot strategy for synthesis of orange fluorescent gold nanoclusters (MBISA-AuNCs) at room temperature by using 2-Mercapto-5-benzimidazolesulfonic acid (MBISA) as both reducing and protecting reagent. The prepared AuNCs exhibited prominent advantages including high fluorescent quantum yield, good water solubility, excellent biocompatibility and low toxicity. Based on these superior properties, the AuNCs have been multi-talented applied in cell imaging, hydrogen sulfide detection and pH sensing. Confocal fluorescence imaging showed that the MBISA-AuNCs could enter living cells and distribute in the cytoplasm. Additionally, the obtained AuNCs could visualize H

Topics: Benzimidazoles; Cell Line, Tumor; Cell Survival; Fluorescent Dyes; Gold; Humans; Hydrogen Sulfide; Hydrogen-Ion Concentration; Liver Neoplasms; Metal Nanoparticles; Microscopy, Fluorescence; Molecular Structure; Optical Imaging; Sulfonic Acids