2-keto-4-methylvalerate has been researched along with Seizures in 2 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " KIV elicited clonic convulsions in a dose-response manner, whereas KIC and KMV did not induce seizure-like behavior." | 1.31 | Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. ( Coitinho, AS; de Bastiani, J; de Mello, CF; Fighera, MR; Lima, TT; Wajner, M, 2001) |
| "KIV elicited clonic convulsions in a dose-response manner, whereas KIC and KMV did not induce seizure-like behavior." | 1.31 | Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats. ( Coitinho, AS; de Bastiani, J; de Mello, CF; Fighera, MR; Lima, TT; Wajner, M, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dufour, F | 1 |
| Nalecz, KA | 1 |
| Nalecz, MJ | 1 |
| Nehlig, A | 1 |
| Coitinho, AS | 1 |
| de Mello, CF | 1 |
| Lima, TT | 1 |
| de Bastiani, J | 1 |
| Fighera, MR | 1 |
| Wajner, M | 1 |
2 other studies available for 2-keto-4-methylvalerate and Seizures
| Article | Year |
|---|---|
Modulation of pentylenetetrazol-induced seizure activity by branched-chain amino acids and alpha-ketoisocaproate.
Topics: Amino Acids, Branched-Chain; Animals; Caproates; Electroencephalography; Injections, Intraventricula | 1999 |
Pharmacological evidence that alpha-ketoisovaleric acid induces convulsions through GABAergic and glutamatergic mechanisms in rats.
Topics: Animals; Corpus Striatum; Excitatory Amino Acid Antagonists; GABA Agonists; Hemiterpenes; Keto Acids | 2001 |