2-keto-4-methylvalerate has been researched along with Pregnancy in 21 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to approach the effect of preeclampsia in the mother on neonatal protein turnover, we studied the leucine turnover in preterm infants soon after birth and again after 7 days." | 5.31 | Effect of preeclampsia in the mother on the leucine metabolism in the newborn infant. ( Lotgering, FK; Saenz De Pipaón Marcos, M; Sauer, PJ; Van Beek, RH; Wattimena, DJ, 2002) |
| " In eight chronically prepared fetal lambs, we compared leucine kinetics (reciprocal pool model) during control conditions with measurements made during maternal hypoxia, a condition that limits fetal oxygen availability." | 3.70 | Ovine fetal leucine kinetics and protein metabolism during decreased oxygen availability. ( Milley, JR, 1998) |
| "We measured leucine flux rates during infusions of L-[1-14C]- and L-[1-1C]leucine in fetal sheep exposed to maternal insulin-induced hypoglycemia over the last 8 wk (40%) of gestation to determine effects of chronic glucose deficiency and hypoglycemia on fetal leucine metabolism." | 3.69 | Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep. ( Carver, TD; Fennessey, PV; Hay, WW; Pike, AW; Quick, AA; Teng, CC, 1997) |
| " Starvation of the mother for days 18-20 did not alter CO2 evolution from alpha-ketoisocaproic acid in fetal brain slices but significantly diminished the incorporation of the branched-chain keto acids into leucine." | 3.66 | Fetal fuels VI. Metabolism of alpha-ketoisocaproic acid in fetal rat brain. ( Koehler, RA; Shambaugh, GE, 1983) |
| "Pregnancy is characterized by a rapid accumulation of lipid stores during the first half of gestation and a utilization of these stores during the latter half of gestation." | 2.37 | Ketone body metabolism in the mother and fetus. ( Shambaugh, GE, 1985) |
| "In order to approach the effect of preeclampsia in the mother on neonatal protein turnover, we studied the leucine turnover in preterm infants soon after birth and again after 7 days." | 1.31 | Effect of preeclampsia in the mother on the leucine metabolism in the newborn infant. ( Lotgering, FK; Saenz De Pipaón Marcos, M; Sauer, PJ; Van Beek, RH; Wattimena, DJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van den Akker, CH | 1 |
| Schierbeek, H | 1 |
| Minderman, G | 1 |
| Vermes, A | 1 |
| Schoonderwaldt, EM | 1 |
| Duvekot, JJ | 1 |
| Steegers, EA | 1 |
| van Goudoever, JB | 1 |
| de Pipaón, MS | 1 |
| VanBeek, RH | 1 |
| Zimmermann, LJ | 1 |
| Wattimena, DJ | 2 |
| Quero, J | 1 |
| Sauer, PJ | 2 |
| Shambaugh, GE | 2 |
| Koehler, RA | 1 |
| Wendel, U | 1 |
| Gamm, G | 1 |
| Claussen, U | 1 |
| Eriksson, UJ | 1 |
| Borg, LA | 1 |
| Milley, JR | 2 |
| Sweeley, JC | 1 |
| Ross, JC | 1 |
| Fennessey, PV | 3 |
| Wilkening, RB | 1 |
| Battaglia, FC | 2 |
| Meschia, G | 2 |
| Carver, TD | 1 |
| Quick, AA | 1 |
| Teng, CC | 1 |
| Pike, AW | 1 |
| Hay, WW | 1 |
| Malaisse-Lagae, F | 1 |
| Vanhoutte, C | 1 |
| Rypens, F | 1 |
| Louryan, S | 1 |
| Malaisse, WJ | 1 |
| Whittaker, PG | 1 |
| Lee, CH | 1 |
| Cooper, BG | 1 |
| Taylor, R | 1 |
| Sjöholm, A | 1 |
| Sandberg, E | 1 |
| Ostenson, CG | 1 |
| Efendic, S | 1 |
| Saenz De Pipaón Marcos, M | 1 |
| Van Beek, RH | 1 |
| Lotgering, FK | 1 |
| Liechty, EA | 2 |
| Denne, SC | 1 |
| Lemons, JA | 2 |
| Kien, CL | 1 |
| Kelley, J | 1 |
| Loy, GL | 1 |
| Quick, AN | 1 |
| Takao, F | 1 |
| Smeaton, TC | 1 |
| Owens, JA | 1 |
| Kind, KL | 1 |
| Robinson, JS | 1 |
| Vandehaar, MJ | 1 |
| Flakoll, PJ | 1 |
| Beitz, DC | 1 |
| Nissen, S | 1 |
| Oddy, VH | 1 |
| Lindsay, DB | 1 |
| Fleet, IR | 1 |
1 review available for 2-keto-4-methylvalerate and Pregnancy
| Article | Year |
|---|---|
Ketone body metabolism in the mother and fetus.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Brain; Embryonic and Fetal Development; Female; Gluco | 1985 |
20 other studies available for 2-keto-4-methylvalerate and Pregnancy
| Article | Year |
|---|---|
Amino acid metabolism in the human fetus at term: leucine, valine, and methionine kinetics.
Topics: Blood Flow Velocity; Carbon Isotopes; Female; Fetal Blood; Fetus; Hemiterpenes; Humans; Keto Acids; | 2011 |
Effects of antenatal steroids on protein metabolism in preterm infants on the first day of life.
Topics: Betamethasone; Female; Gastrointestinal Tract; Glucocorticoids; Humans; Infant, Newborn; Infant, Pre | 2004 |
Fetal fuels VI. Metabolism of alpha-ketoisocaproic acid in fetal rat brain.
Topics: Animals; Biotransformation; Brain; Energy Metabolism; Female; Fetus; Keto Acids; Leucine; Maternal-F | 1983 |
Maple syrup urine disease: alpha-ketoisocaproate decarboxylation activity in different types of cultured amniotic fluid cells.
Topics: Amniotic Fluid; Cells, Cultured; Decarboxylation; Epithelium; Female; Fibroblasts; Humans; Keto Acid | 1981 |
Diabetes and embryonic malformations. Role of substrate-induced free-oxygen radical production for dysmorphogenesis in cultured rat embryos.
Topics: 3-Hydroxybutyric Acid; Animals; Congenital Abnormalities; Culture Techniques; Embryo, Mammalian; Fem | 1993 |
High-performance liquid chromatographic measurement of leucine and alpha-ketoisocaproate in whole blood: application to fetal protein metabolism.
Topics: Animals; Antipyrine; Carbon Dioxide; Chromatography, High Pressure Liquid; Female; Fetal Proteins; K | 1993 |
Placental transport and fetal utilization of leucine in a model of fetal growth retardation.
Topics: Animals; Blood Glucose; Female; Fetal Growth Retardation; Hot Temperature; Keto Acids; Leucine; Live | 1996 |
Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep.
Topics: Animals; Blood Glucose; Body Weight; Carbon Isotopes; Chronic Disease; Female; Fetal Blood; Fetal Gr | 1997 |
Anomalies of fetal development in GK rats.
Topics: Animals; Diabetes Mellitus, Type 2; Embryonic and Fetal Development; Female; Fetal Diseases; Fetus; | 1997 |
Ovine fetal leucine kinetics and protein metabolism during decreased oxygen availability.
Topics: Animals; Biological Availability; Carbon Dioxide; Female; Fetal Blood; Fetus; Hematocrit; Hydrogen-I | 1998 |
Evaluation of phenylalanine and tyrosine metabolism in late human pregnancy.
Topics: Adult; Female; Homeostasis; Humans; Hydroxylation; Keto Acids; Kinetics; Leucine; Oxidation-Reductio | 1999 |
Regulation of in vitro maturation of stimulus-secretion coupling in fetal rat islet beta-cells.
Topics: Adrenergic alpha-Antagonists; Animals; Cells, Cultured; Culture Media; Cyclic AMP; Cyclic AMP-Depend | 2000 |
Effect of preeclampsia in the mother on the leucine metabolism in the newborn infant.
Topics: Aging; Birth Weight; Carbon Isotopes; Dietary Proteins; Energy Intake; Female; Gestational Age; Huma | 2002 |
Effects of glucose infusion on leucine transamination and oxidation in the ovine fetus.
Topics: Animals; Carbon; Female; Fetus; Glucose; Infusions, Intravenous; Keto Acids; Kinetics; Leucine; Nitr | 1991 |
Effect of fasting on uteroplacental amino acid metabolism in the pregnant sheep.
Topics: Amino Acids; Analysis of Variance; Animals; Blood Flow Velocity; Fasting; Female; Fetal Blood; Fetus | 1991 |
Measurement of leucine and alpha-ketoisocaproic acid fluxes in the fetal/placental unit.
Topics: Animals; Antipyrine; Carbon Isotopes; Female; Fetus; Keto Acids; Leucine; Maternal-Fetal Exchange; P | 1991 |
[The effect of maternal hyperglycemia on insulin secretion by monolayer-cultured B cells of neonatal rats--a perifusion study].
Topics: Animals; Animals, Newborn; Arginine; Cells, Cultured; Female; Glucose; Hyperglycemia; Insulin; Insul | 1989 |
The placenta releases branched-chain keto acids into the umbilical and uterine circulations in the pregnant sheep.
Topics: Animals; Blood Circulation; Female; Fetal Blood; Fetus; Hemiterpenes; Keto Acids; Maternal-Fetal Exc | 1989 |
Milk production and composition in cows and goats fed alpha-ketoisocaproate.
Topics: Animals; Caproates; Cattle; Female; Goats; Keto Acids; Lactation; Milk; Pregnancy | 1988 |
Protein synthesis and degradation in the mammary gland of lactating goats.
Topics: Animals; Caproates; Female; Goats; Infusions, Intra-Arterial; Keto Acids; Lactation; Leucine; Mammar | 1988 |