2-keto-4-methylvalerate has been researched along with Pancreatic Neoplasms in 4 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose." | 3.69 | Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995) |
| "We studied the release of insulin, glucagon, and somatostatin in response to glucose, glyceraldehyde (GA), and alpha-ketoisocaproate (KIC) from rat kidneys containing transplanted insulinomas." | 3.67 | Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984) |
| "The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose." | 1.29 | Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995) |
| "Cytochalasin B did not enhance this primed glucose response." | 1.27 | Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984) |
| "These findings show that this islet cell tumor transplanted under the kidney capsule releases insulin in response to physiologic and model fuel substances." | 1.27 | Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| James, AD | 1 |
| Patel, W | 1 |
| Butt, Z | 1 |
| Adiamah, M | 1 |
| Dakhel, R | 1 |
| Latif, A | 1 |
| Uggenti, C | 1 |
| Swanton, E | 1 |
| Imamura, H | 1 |
| Siriwardena, AK | 1 |
| Bruce, JI | 1 |
| Hoenig, M | 1 |
| Ferguson, DC | 1 |
| Matschinsky, FM | 1 |
| Battezzati, A | 1 |
| Terruzzi, I | 1 |
| Perseghin, G | 1 |
| Bianchi, E | 1 |
| Di Carlo, V | 1 |
| Pozza, G | 1 |
| Luzi, L | 1 |
| Barreto, M | 1 |
| Sener, A | 1 |
| Malaisse, WJ | 1 |
| Valverde, I | 1 |
4 other studies available for 2-keto-4-methylvalerate and Pancreatic Neoplasms
| Article | Year |
|---|---|
The Plasma Membrane Calcium Pump in Pancreatic Cancer Cells Exhibiting the Warburg Effect Relies on Glycolytic ATP.
Topics: Adenocarcinoma; Adenosine Triphosphate; Calcium; Cell Line, Tumor; Cell Membrane; Cytosol; Enzyme In | 2015 |
Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney.
Topics: Adenoma, Islet Cell; Animals; Cytochalasin B; Diazoxide; Glucagon; Glucose; Glyceraldehyde; Humans; | 1984 |
Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma.
Topics: Adult; Blood Glucose; Carbon Radioisotopes; Chronic Disease; Glucose; Glucose Clamp Technique; Human | 1995 |
Inhibition by a nonmetabolized analogue of L-leucine of protein biosynthesis in tumoral pancreatic islet cells.
Topics: Adenoma, Islet Cell; Amino Acids; Amino Acids, Cyclic; Keto Acids; Leucine; Neoplasm Proteins; Pancr | 1989 |