2-keto-4-methylvalerate has been researched along with Obesity in 12 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Obesity: A status with BODY WEIGHT that is grossly above the recommended standards, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To examine whether moderate obesity and differences in body fat distribution are associated with abnormalities of protein metabolism, leucine turnover was measured in three groups of age-matched premenopausal women." | 7.68 | Protein metabolism in obesity: effects of body fat distribution and hyperinsulinemia on leucine turnover. ( Haymond, MW; Jensen, MD, 1991) |
| "To examine whether moderate obesity and differences in body fat distribution are associated with abnormalities of protein metabolism, leucine turnover was measured in three groups of age-matched premenopausal women." | 3.68 | Protein metabolism in obesity: effects of body fat distribution and hyperinsulinemia on leucine turnover. ( Haymond, MW; Jensen, MD, 1991) |
| "Ageing and type 2 diabetes mellitus (T2DM) are risk factors for skeletal muscle loss." | 1.46 | Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity. ( Babraj, J; Cuthbertson, DJ; Leese, G; Siervo, M, 2017) |
| " Whereas the reduction in Ca2+i was related to the extracellular glucose concentration in a hyperbolic manner, the increasing component exhibited a sigmoidal dose-response relationship." | 1.27 | Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse beta-cells. ( Gylfe, E, 1988) |
| "Obesity was associated with a significant increase in postabsorptive plasma concentrations of the branched-chain keto acids in men but not in women matched for body-mass index and age." | 1.27 | Sex-specific differences in plasma branched-chain keto acid levels in obesity. ( Herbertz, L; Langer, K; Schauder, P; Zavelberg, D, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cuthbertson, DJ | 1 |
| Babraj, J | 1 |
| Leese, G | 1 |
| Siervo, M | 1 |
| Crujeiras, AB | 1 |
| Parra, D | 2 |
| Goyenechea, E | 1 |
| Abete, I | 1 |
| González-Muniesa, P | 1 |
| Martínez, JA | 2 |
| González, A | 1 |
| Labayen, I | 1 |
| Díez, N | 1 |
| Best, L | 1 |
| Malaisse, WJ | 1 |
| Mitch, WE | 1 |
| Walser, M | 1 |
| Sapir, DG | 1 |
| Zhou, YP | 1 |
| Berggren, PO | 1 |
| Grill, V | 1 |
| Luzi, L | 1 |
| Castellino, P | 1 |
| DeFronzo, RA | 1 |
| Balagopal, P | 1 |
| Sweeten, S | 1 |
| Mauras, N | 1 |
| Lucidi, P | 1 |
| Parlanti, N | 1 |
| Piccioni, F | 1 |
| Santeusanio, F | 1 |
| De Feo, P | 1 |
| Jensen, MD | 1 |
| Haymond, MW | 1 |
| Gylfe, E | 1 |
| Schauder, P | 1 |
| Zavelberg, D | 1 |
| Langer, K | 1 |
| Herbertz, L | 1 |
1 review available for 2-keto-4-methylvalerate and Obesity
| Article | Year |
|---|---|
Phospholipids and islet function.
Topics: Amino Acids; Animals; Arachidonic Acid; Arachidonic Acids; Calcium; Fatty Acids; Glucose; Hormones; | 1983 |
2 trials available for 2-keto-4-methylvalerate and Obesity
| Article | Year |
|---|---|
In vivo assessment of the mitochondrial response to caloric restriction in obese women by the 2-keto[1-C]isocaproate breath test.
Topics: Adolescent; Adult; Body Composition; Body Weight; Breath Tests; Caloric Restriction; Energy Metaboli | 2003 |
Short-term treatment with low doses of recombinant human GH stimulates lipolysis in visceral obese men.
Topics: Adult; Blood Glucose; C-Peptide; Dose-Response Relationship, Drug; Double-Blind Method; Drug Adminis | 2002 |
9 other studies available for 2-keto-4-methylvalerate and Obesity
| Article | Year |
|---|---|
Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity.
Topics: Absorptiometry, Photon; Adaptor Proteins, Signal Transducing; Aged; Amino Acids, Essential; Anabolic | 2017 |
Energy restriction in obese subjects impact differently two mitochondrial function markers.
Topics: Adenosine Triphosphate; Adult; Biomarkers; Breath Tests; C-Reactive Protein; Caloric Restriction; Di | 2008 |
Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man.
Topics: Adult; Amino Acids; Fasting; Female; Humans; Infusions, Parenteral; Keto Acids; Leucine; Male; Middl | 1981 |
A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.
Topics: Aging; Animals; Carnitine O-Palmitoyltransferase; Cells, Cultured; Crosses, Genetic; Diabetes Mellit | 1996 |
Insulin and hyperaminoacidemia regulate by a different mechanism leucine turnover and oxidation in obesity.
Topics: Adult; Amino Acids; Amino Acids, Branched-Chain; Blood Glucose; Body Composition; Female; Humans; In | 1996 |
Increased synthesis rate of fibrinogen as a basis for its elevated plasma levels in obese female adolescents.
Topics: Adolescent; Blood Glucose; Body Mass Index; Carbon Isotopes; Chromatography, Affinity; Female; Fibri | 2002 |
Protein metabolism in obesity: effects of body fat distribution and hyperinsulinemia on leucine turnover.
Topics: Adipose Tissue; Body Mass Index; Caproates; Female; Humans; Insulin; Keto Acids; Leucine; Obesity; P | 1991 |
Nutrient secretagogues induce bimodal early changes in cytoplasmic calcium of insulin-releasing ob/ob mouse beta-cells.
Topics: Amino Acids; Amino Acids, Cyclic; Animals; Arginine; Calcium; Cytoplasm; Dose-Response Relationship, | 1988 |
Sex-specific differences in plasma branched-chain keto acid levels in obesity.
Topics: Blood Glucose; Body Composition; Female; Hemiterpenes; Humans; Insulin; Insulin Resistance; Isoleuci | 1987 |