2-keto-4-methylvalerate has been researched along with Liver Diseases, Alcoholic in 4 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Liver Diseases, Alcoholic: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In contrast to previous studies, we found no significant impairment of Ketoisocaproate decarboxylation as an effect of chronic intake of alcohol or alcohol-induced steatosis." | 1.30 | Evaluation of the carbon 13-labeled Ketoisocaproate breath test to assess mitochondrial dysfunction in patients with high alcohol consumption. ( Bendtsen, P; Hannestad, U; Påhlsson, P, 1998) |
| " The enrichment of circulating KICA with [13C]KICA was similar in alcoholics and controls, indicating that a decreased bioavailability or an increased dilution of labeled KICA cannot account for the decreased exhalation of 13CO2." | 1.29 | Mitochondrial function reflected by the decarboxylation of [13C]ketoisocaproate is impaired in alcoholics. ( Junker, E; Lauterburg, BH; Meyer, B; Mossi, S; Witschi, A, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Parra, D | 1 |
| González, A | 1 |
| García-Villarreal, L | 1 |
| Martínez, JA | 1 |
| Tarantino, G | 1 |
| Di Bernardo, C | 1 |
| Vitaglione, R | 1 |
| Cambri, S | 1 |
| Witschi, A | 1 |
| Mossi, S | 1 |
| Meyer, B | 1 |
| Junker, E | 1 |
| Lauterburg, BH | 1 |
| Bendtsen, P | 1 |
| Hannestad, U | 1 |
| Påhlsson, P | 1 |
1 review available for 2-keto-4-methylvalerate and Liver Diseases, Alcoholic
| Article | Year |
|---|---|
[New trends in the therapy of alcoholic hepatic diseases].
Topics: Adrenal Cortex Hormones; Amino Acids; Androgens; Animals; Antithyroid Agents; Colchicine; Enzyme Ind | 1984 |
3 other studies available for 2-keto-4-methylvalerate and Liver Diseases, Alcoholic
| Article | Year |
|---|---|
Methodological characterization of the 2-keto [1-13C]isocaproate breath test to measure in vivo human mitochondrial function: application in alcoholic liver disease assessment.
Topics: Adolescent; Adult; Analysis of Variance; Breath Tests; Carbon Dioxide; Carbon Radioisotopes; Female; | 2003 |
Mitochondrial function reflected by the decarboxylation of [13C]ketoisocaproate is impaired in alcoholics.
Topics: Adult; Aged; Breath Tests; Decarboxylation; Female; Humans; Keto Acids; Liver Cirrhosis, Alcoholic; | 1994 |
Evaluation of the carbon 13-labeled Ketoisocaproate breath test to assess mitochondrial dysfunction in patients with high alcohol consumption.
Topics: Adult; Breath Tests; Carbon Dioxide; Carbon Isotopes; Female; Humans; Keto Acids; Liver Diseases, Al | 1998 |