2-keto-4-methylvalerate has been researched along with Kidney Failure, Chronic in 13 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation is highly prevalent in chronic hemodialysis patients." | 1.31 | Inflammatory signals associated with hemodialysis. ( Caglar, K; Flakoll, PJ; Hakim, RM; Ikizler, TA; Levenhagen, D; Peng, Y; Pupim, LB, 2002) |
| "During hyperinsulinemia (study 1), IDDUP showed a defective decrease of leucine (42% vs." | 1.29 | Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients. ( Battezzati, A; Bianchi, E; Ferrari, G; La Rocca, E; Luzi, L; Perseghin, G; Secchi, A; Spotti, D; Terruzzi, I; Vergani, S, 1994) |
| "To see how chronic uremia affects R, 11/12 nephrectomized rats and sham-operated controls were fed a regular diet for 15 days and then given these isotopes p." | 1.27 | Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats. ( Kang, CW; Tungsanga, K; Walser, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caglar, K | 1 |
| Peng, Y | 1 |
| Pupim, LB | 1 |
| Flakoll, PJ | 1 |
| Levenhagen, D | 1 |
| Hakim, RM | 1 |
| Ikizler, TA | 1 |
| Yang, H | 1 |
| Zheng, F | 1 |
| Jiang, J | 1 |
| Hu, P | 1 |
| Li, X | 1 |
| Schauder, P | 2 |
| Matthaei, D | 2 |
| Henning, HV | 1 |
| Scheler, F | 2 |
| Langenbeck, U | 2 |
| Oh, HY | 1 |
| Fadda, GZ | 1 |
| Smogorzewski, M | 1 |
| Liou, HH | 1 |
| Massry, SG | 1 |
| Luzi, L | 3 |
| Battezzati, A | 1 |
| Perseghin, G | 1 |
| Bianchi, E | 1 |
| Terruzzi, I | 1 |
| Spotti, D | 1 |
| Vergani, S | 1 |
| Secchi, A | 1 |
| La Rocca, E | 1 |
| Ferrari, G | 1 |
| Garibotto, G | 1 |
| Paoletti, E | 1 |
| Fiorini, F | 1 |
| Russo, R | 1 |
| Robaudo, C | 1 |
| Deferrari, G | 1 |
| Tizianello, A | 1 |
| Biolo, G | 1 |
| Toigo, G | 1 |
| Ciocchi, B | 1 |
| Morena, G | 1 |
| Situlin, R | 1 |
| Vasile, A | 1 |
| Carraro, M | 1 |
| Faccini, L | 1 |
| Guarnieri, G | 1 |
| Castellino, P | 2 |
| Giordano, M | 2 |
| Defronzo, RA | 2 |
| Kramer, P | 1 |
| Grieben, K | 1 |
| Mench-Hoinowski, A | 1 |
| Solini, A | 1 |
| Barr, JG | 1 |
| Smith, DJ | 1 |
| Petrides, A | 1 |
| Carroll, C | 1 |
| Barratt, TM | 1 |
| Chantler, C | 1 |
| Lederman, S | 1 |
| Rigden, SP | 1 |
| Tungsanga, K | 1 |
| Kang, CW | 1 |
| Walser, M | 1 |
| Bode, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Monocentric Prospective Randomized Pilot Study in Patients With Kidney Failure to Evaluate the Relationship Between the Hemadsorption During and After Cardiopulmonary Bypass and the Modulation of Post-surgical Inflammatory Response[NCT04157647] | 40 participants (Anticipated) | Interventional | 2020-11-15 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for 2-keto-4-methylvalerate and Kidney Failure, Chronic
| Article | Year |
|---|---|
Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients.
Topics: Adult; Amino Acids; Blood Glucose; Calorimetry, Indirect; Female; Glucose; Hormones; Humans; Insulin | 1999 |
Assessment of renal function.
Topics: Adult; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Creatinine; Double-Blind Meth | 1986 |
11 other studies available for 2-keto-4-methylvalerate and Kidney Failure, Chronic
| Article | Year |
|---|---|
Inflammatory signals associated with hemodialysis.
Topics: Adult; Biomarkers; Carbon Isotopes; Female; Fibrinogen; Humans; Inflammation; Interleukin-6; Keto Ac | 2002 |
[Plasma branched-chain ketoacids metabolism in patients with chronic renal failure after oral administration of ketosteril].
Topics: Administration, Oral; Adult; Amino Acids, Essential; Female; Hemiterpenes; Humans; Keto Acids; Kidne | 1999 |
Blood levels of branched-chain alpha-keto acids in uremia: effect of an oral glucose tolerance test.
Topics: Adult; Blood Glucose; C-Peptide; Female; Glucose Tolerance Test; Hemiterpenes; Humans; Insulin; Keto | 1981 |
Abnormal leucine-induced insulin secretion in chronic renal failure.
Topics: Animals; Body Weight; Bridged Bicyclo Compounds; Creatinine; Glutamate Dehydrogenase; Glutaminase; I | 1994 |
Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Hemoglobins; Hormones; Humans; Hyperinsulin | 1994 |
Peripheral metabolism of branched-chain keto acids in patients with chronic renal failure.
Topics: Adult; Amino Acids, Branched-Chain; Bicarbonates; Female; Hemiterpenes; Humans; Isoleucine; Keto Aci | 1993 |
Relationship between whole-body protein turnover and serum creatinine in chronically uremic patients.
Topics: Adult; Aged; Body Mass Index; Carbon Isotopes; Creatinine; Female; Humans; Hydrogen-Ion Concentratio | 1998 |
Plasma keto-analogues in uraemic patients.
Topics: Amino Acids; Creatinine; Hemiterpenes; Humans; Keto Acids; Kidney Failure, Chronic; Renal Dialysis; | 1979 |
Glucose and amino acid metabolism in chronic renal failure: effect of insulin and amino acids.
Topics: Adult; Amino Acids; Blood Glucose; Glucose; Hormones; Humans; Insulin; Keto Acids; Kidney Failure, C | 1992 |
Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats.
Topics: Animals; Blood Proteins; Body Weight; Keto Acids; Kidney Failure, Chronic; Leucine; Nephrectomy; Pro | 1986 |
[Branched-chain amino acids and their ketoanalogs: therapeutic uses in patients with chronic liver or kidney failure].
Topics: Administration, Oral; Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Essential; Blood-Brain | 1985 |