Page last updated: 2024-10-15

2-keto-4-methylvalerate and Kidney Failure, Chronic

2-keto-4-methylvalerate has been researched along with Kidney Failure, Chronic in 13 studies

alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.

Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.

Research Excerpts

ExcerptRelevanceReference
"Inflammation is highly prevalent in chronic hemodialysis patients."1.31Inflammatory signals associated with hemodialysis. ( Caglar, K; Flakoll, PJ; Hakim, RM; Ikizler, TA; Levenhagen, D; Peng, Y; Pupim, LB, 2002)
"During hyperinsulinemia (study 1), IDDUP showed a defective decrease of leucine (42% vs."1.29Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients. ( Battezzati, A; Bianchi, E; Ferrari, G; La Rocca, E; Luzi, L; Perseghin, G; Secchi, A; Spotti, D; Terruzzi, I; Vergani, S, 1994)
"To see how chronic uremia affects R, 11/12 nephrectomized rats and sham-operated controls were fed a regular diet for 15 days and then given these isotopes p."1.27Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats. ( Kang, CW; Tungsanga, K; Walser, M, 1986)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19905 (38.46)18.7374
1990's7 (53.85)18.2507
2000's1 (7.69)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Caglar, K1
Peng, Y1
Pupim, LB1
Flakoll, PJ1
Levenhagen, D1
Hakim, RM1
Ikizler, TA1
Yang, H1
Zheng, F1
Jiang, J1
Hu, P1
Li, X1
Schauder, P2
Matthaei, D2
Henning, HV1
Scheler, F2
Langenbeck, U2
Oh, HY1
Fadda, GZ1
Smogorzewski, M1
Liou, HH1
Massry, SG1
Luzi, L3
Battezzati, A1
Perseghin, G1
Bianchi, E1
Terruzzi, I1
Spotti, D1
Vergani, S1
Secchi, A1
La Rocca, E1
Ferrari, G1
Garibotto, G1
Paoletti, E1
Fiorini, F1
Russo, R1
Robaudo, C1
Deferrari, G1
Tizianello, A1
Biolo, G1
Toigo, G1
Ciocchi, B1
Morena, G1
Situlin, R1
Vasile, A1
Carraro, M1
Faccini, L1
Guarnieri, G1
Castellino, P2
Giordano, M2
Defronzo, RA2
Kramer, P1
Grieben, K1
Mench-Hoinowski, A1
Solini, A1
Barr, JG1
Smith, DJ1
Petrides, A1
Carroll, C1
Barratt, TM1
Chantler, C1
Lederman, S1
Rigden, SP1
Tungsanga, K1
Kang, CW1
Walser, M1
Bode, JC1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Monocentric Prospective Randomized Pilot Study in Patients With Kidney Failure to Evaluate the Relationship Between the Hemadsorption During and After Cardiopulmonary Bypass and the Modulation of Post-surgical Inflammatory Response[NCT04157647]40 participants (Anticipated)Interventional2020-11-15Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for 2-keto-4-methylvalerate and Kidney Failure, Chronic

ArticleYear
Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients.
    Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:5

    Topics: Adult; Amino Acids; Blood Glucose; Calorimetry, Indirect; Female; Glucose; Hormones; Humans; Insulin

1999
Assessment of renal function.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1986, Volume: 7, Issue:4

    Topics: Adult; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Creatinine; Double-Blind Meth

1986

Other Studies

11 other studies available for 2-keto-4-methylvalerate and Kidney Failure, Chronic

ArticleYear
Inflammatory signals associated with hemodialysis.
    Kidney international, 2002, Volume: 62, Issue:4

    Topics: Adult; Biomarkers; Carbon Isotopes; Female; Fibrinogen; Humans; Inflammation; Interleukin-6; Keto Ac

2002
[Plasma branched-chain ketoacids metabolism in patients with chronic renal failure after oral administration of ketosteril].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 1999, Volume: 21, Issue:6

    Topics: Administration, Oral; Adult; Amino Acids, Essential; Female; Hemiterpenes; Humans; Keto Acids; Kidne

1999
Blood levels of branched-chain alpha-keto acids in uremia: effect of an oral glucose tolerance test.
    Klinische Wochenschrift, 1981, Aug-03, Volume: 59, Issue:15

    Topics: Adult; Blood Glucose; C-Peptide; Female; Glucose Tolerance Test; Hemiterpenes; Humans; Insulin; Keto

1981
Abnormal leucine-induced insulin secretion in chronic renal failure.
    The American journal of physiology, 1994, Volume: 267, Issue:5 Pt 2

    Topics: Animals; Body Weight; Bridged Bicyclo Compounds; Creatinine; Glutamate Dehydrogenase; Glutaminase; I

1994
Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients.
    The Journal of clinical investigation, 1994, Volume: 93, Issue:5

    Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Hemoglobins; Hormones; Humans; Hyperinsulin

1994
Peripheral metabolism of branched-chain keto acids in patients with chronic renal failure.
    Mineral and electrolyte metabolism, 1993, Volume: 19, Issue:1

    Topics: Adult; Amino Acids, Branched-Chain; Bicarbonates; Female; Hemiterpenes; Humans; Isoleucine; Keto Aci

1993
Relationship between whole-body protein turnover and serum creatinine in chronically uremic patients.
    Mineral and electrolyte metabolism, 1998, Volume: 24, Issue:4

    Topics: Adult; Aged; Body Mass Index; Carbon Isotopes; Creatinine; Female; Humans; Hydrogen-Ion Concentratio

1998
Plasma keto-analogues in uraemic patients.
    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association, 1979, Volume: 16

    Topics: Amino Acids; Creatinine; Hemiterpenes; Humans; Keto Acids; Kidney Failure, Chronic; Renal Dialysis;

1979
Glucose and amino acid metabolism in chronic renal failure: effect of insulin and amino acids.
    The American journal of physiology, 1992, Volume: 262, Issue:2 Pt 2

    Topics: Adult; Amino Acids; Blood Glucose; Glucose; Hormones; Humans; Insulin; Keto Acids; Kidney Failure, C

1992
Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats.
    Kidney international, 1986, Volume: 30, Issue:6

    Topics: Animals; Blood Proteins; Body Weight; Keto Acids; Kidney Failure, Chronic; Leucine; Nephrectomy; Pro

1986
[Branched-chain amino acids and their ketoanalogs: therapeutic uses in patients with chronic liver or kidney failure].
    Der Internist, 1985, Volume: 26, Issue:7

    Topics: Administration, Oral; Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Essential; Blood-Brain

1985