2-keto-4-methylvalerate has been researched along with Disease Models, Animal in 9 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Most patients at risk for developing type 2 diabetes are hyperinsulinemic." | 1.33 | Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. ( Attie, AD; Frey, BL; Gray-Keller, MP; Rabaglia, ME; Shortreed, MR; Smith, LM, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 6 (66.67) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| S Sonnet, D | 1 |
| N O'Leary, M | 1 |
| A Gutierrez, M | 1 |
| M Nguyen, S | 1 |
| Mateen, S | 1 |
| Hsu, Y | 1 |
| P Mitchell, K | 1 |
| J Lopez, A | 1 |
| Vockley, J | 1 |
| K Kennedy, B | 1 |
| Ramanathan, A | 1 |
| Zinnanti, WJ | 1 |
| Lazovic, J | 1 |
| Griffin, K | 1 |
| Skvorak, KJ | 1 |
| Paul, HS | 1 |
| Homanics, GE | 1 |
| Bewley, MC | 1 |
| Cheng, KC | 1 |
| Lanoue, KF | 1 |
| Flanagan, JM | 1 |
| Sgaravatti, AM | 1 |
| Rosa, RB | 1 |
| Schuck, PF | 1 |
| Ribeiro, CA | 1 |
| Wannmacher, CM | 2 |
| Wyse, AT | 1 |
| Dutra-Filho, CS | 2 |
| Wajner, M | 2 |
| Rabaglia, ME | 1 |
| Gray-Keller, MP | 1 |
| Frey, BL | 1 |
| Shortreed, MR | 1 |
| Smith, LM | 1 |
| Attie, AD | 1 |
| Bridi, R | 1 |
| Braun, CA | 1 |
| Zorzi, GK | 1 |
| Lissi, EG | 1 |
| Gunawardana, SC | 1 |
| Head, WS | 1 |
| Piston, DW | 1 |
| Tsuura, Y | 1 |
| Ishida, H | 1 |
| Okamoto, Y | 1 |
| Kato, S | 1 |
| Sakamoto, K | 1 |
| Horie, M | 1 |
| Ikeda, H | 1 |
| Okada, Y | 1 |
| Seino, Y | 1 |
| Hirokawa, M | 1 |
| Walser, M | 1 |
| Dufour, F | 1 |
| Nalecz, KA | 1 |
| Nalecz, MJ | 1 |
| Nehlig, A | 1 |
9 other studies available for 2-keto-4-methylvalerate and Disease Models, Animal
| Article | Year |
|---|---|
Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD.
Topics: Amino Acids, Branched-Chain; Animals; Chromatography, Liquid; Disease Models, Animal; Female; Fibrob | 2016 |
Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease.
Topics: Amino Acids; Animals; Behavior, Animal; Brain; Brain Edema; Brain Mapping; Dietary Proteins; Disease | 2009 |
Inhibition of brain energy metabolism by the alpha-keto acids accumulating in maple syrup urine disease.
Topics: Animals; Biological Transport; Brain; Carbon Dioxide; Disease Models, Animal; Energy Metabolism; Glu | 2003 |
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutamate Dehydrogenase | 2005 |
alpha-keto acids accumulating in maple syrup urine disease stimulate lipid peroxidation and reduce antioxidant defences in cerebral cortex from young rats.
Topics: Animals; Antioxidants; Catalase; Cerebral Cortex; Disease Models, Animal; Free Radicals; Glutathione | 2005 |
Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes.
Topics: Amiloride; Amino Acids, Cyclic; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Disease | 2008 |
Glucose sensitivity of ATP-sensitive K+ channels is impaired in beta-cells of the GK rat. A new genetic model of NIDDM.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism, Inborn Errors; | 1993 |
Enteral infusion of sodium 2-ketoisocaproate in endotoxic rats.
Topics: Animals; Caproates; Disease Models, Animal; Drug Evaluation, Preclinical; Endotoxemia; Endotoxins; E | 1999 |
Metabolic approach of absence seizures in a genetic model of absence epilepsy, the GAERS: study of the leucine-glutamate cycle.
Topics: Acetates; Amines; Amino Acids, Branched-Chain; Animals; Brain; Carbon Monoxide; Cells, Cultured; Cer | 2001 |