2-keto-4-methylvalerate has been researched along with Diabetes Mellitus, Type 2 in 14 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "77 patients with NAFLD and 11 healthy control subjects were studied." | 1.48 | The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the ( Afolabi, PR; Almehmadi, AA; Byrne, CD; Calder, PC; Scorletti, E; Smith, DE, 2018) |
| "HMF (cPDR over 1 h) was lower in NAFLD compared to controls [13." | 1.48 | The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the ( Afolabi, PR; Almehmadi, AA; Byrne, CD; Calder, PC; Scorletti, E; Smith, DE, 2018) |
| "Ageing and type 2 diabetes mellitus (T2DM) are risk factors for skeletal muscle loss." | 1.46 | Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity. ( Babraj, J; Cuthbertson, DJ; Leese, G; Siervo, M, 2017) |
| "Most patients at risk for developing type 2 diabetes are hyperinsulinemic." | 1.33 | Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. ( Attie, AD; Frey, BL; Gray-Keller, MP; Rabaglia, ME; Shortreed, MR; Smith, LM, 2005) |
| "In several rodent models of type 2 diabetes mellitus, GKAs lowered blood glucose levels, improved the results of glucose tolerance tests, and increased hepatic glucose uptake." | 1.32 | Allosteric activators of glucokinase: potential role in diabetes therapy. ( Bizzarro, FT; Chu, CA; Coffey, JW; Corbett, WL; Dvorozniak, MT; Grimsby, J; Grippo, JF; Guertin, KR; Haynes, NE; Hilliard, DW; Kester, RF; Magnuson, MA; Mahaney, PE; Marcus, L; Matschinsky, FM; Qi, L; Sarabu, R; Spence, CL; Tengi, J, 2003) |
| "Congenic strains for the two subloci (Niddm1f and Niddm1i) have been generated by transfer of GK alleles onto the genome of F344 rats." | 1.31 | Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats. ( Bergsten, P; Fakhrai-Rad, H; Galli, J; Lin, JM; Luthman, H; Ortsäter, H, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.14) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Afolabi, PR | 1 |
| Scorletti, E | 1 |
| Smith, DE | 1 |
| Almehmadi, AA | 1 |
| Calder, PC | 1 |
| Byrne, CD | 1 |
| Stec, DF | 1 |
| Wang, S | 1 |
| Stothers, C | 1 |
| Avance, J | 1 |
| Denson, D | 1 |
| Harris, R | 1 |
| Voziyan, P | 1 |
| Cuthbertson, DJ | 1 |
| Babraj, J | 1 |
| Leese, G | 1 |
| Siervo, M | 1 |
| Grimsby, J | 1 |
| Sarabu, R | 1 |
| Corbett, WL | 1 |
| Haynes, NE | 1 |
| Bizzarro, FT | 1 |
| Coffey, JW | 1 |
| Guertin, KR | 1 |
| Hilliard, DW | 1 |
| Kester, RF | 1 |
| Mahaney, PE | 1 |
| Marcus, L | 1 |
| Qi, L | 1 |
| Spence, CL | 1 |
| Tengi, J | 1 |
| Magnuson, MA | 1 |
| Chu, CA | 1 |
| Dvorozniak, MT | 1 |
| Matschinsky, FM | 1 |
| Grippo, JF | 1 |
| Rabaglia, ME | 1 |
| Gray-Keller, MP | 1 |
| Frey, BL | 1 |
| Shortreed, MR | 1 |
| Smith, LM | 1 |
| Attie, AD | 1 |
| Gustavsson, N | 1 |
| Larsson-Nyrén, G | 1 |
| Lindström, P | 1 |
| Gunawardana, SC | 1 |
| Head, WS | 1 |
| Piston, DW | 1 |
| Lugli, AK | 1 |
| Donatelli, F | 1 |
| Schricker, T | 1 |
| Wykes, L | 1 |
| Carli, F | 1 |
| Tsuura, Y | 1 |
| Ishida, H | 1 |
| Okamoto, Y | 1 |
| Kato, S | 1 |
| Sakamoto, K | 1 |
| Horie, M | 1 |
| Ikeda, H | 1 |
| Okada, Y | 1 |
| Seino, Y | 1 |
| Malaisse-Lagae, F | 1 |
| Vanhoutte, C | 1 |
| Rypens, F | 1 |
| Louryan, S | 1 |
| Malaisse, WJ | 1 |
| Sakura, H | 1 |
| Ashcroft, SJ | 1 |
| Terauchi, Y | 1 |
| Kadowaki, T | 1 |
| Ashcroft, FM | 1 |
| Guenifi, A | 1 |
| Abdel-Halim, SM | 1 |
| Efendic, S | 1 |
| Ostenson, CG | 1 |
| Lin, JM | 1 |
| Ortsäter, H | 1 |
| Fakhrai-Rad, H | 1 |
| Galli, J | 1 |
| Luthman, H | 1 |
| Bergsten, P | 1 |
| Grill, V | 1 |
| Rundfeldt, M | 1 |
1 trial available for 2-keto-4-methylvalerate and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Epidural analgesia enhances the postoperative anabolic effect of amino acids in diabetes mellitus type 2 patients undergoing colon surgery.
Topics: Aged; Amino Acids; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Blood Glu | 2008 |
13 other studies available for 2-keto-4-methylvalerate and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the
Topics: Adult; Breath Tests; Carbon Isotopes; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Human | 2018 |
Alterations of urinary metabolite profile in model diabetic nephropathy.
Topics: Aconitic Acid; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2015 |
Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity.
Topics: Absorptiometry, Photon; Adaptor Proteins, Signal Transducing; Aged; Amino Acids, Essential; Anabolic | 2017 |
Allosteric activators of glucokinase: potential role in diabetes therapy.
Topics: Adaptor Proteins, Signal Transducing; Allosteric Regulation; Animals; Blood Glucose; Carrier Protein | 2003 |
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutamate Dehydrogenase | 2005 |
Pancreatic beta cells from db/db mice show cell-specific [Ca2+]i and NADH responses to glucose but not to alpha-ketoisocaproic acid.
Topics: Animals; Body Weight; Calcium; Diabetes Mellitus, Type 2; Glucose; Glycolysis; In Vitro Techniques; | 2005 |
Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes.
Topics: Amiloride; Amino Acids, Cyclic; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Disease | 2008 |
Glucose sensitivity of ATP-sensitive K+ channels is impaired in beta-cells of the GK rat. A new genetic model of NIDDM.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism, Inborn Errors; | 1993 |
Anomalies of fetal development in GK rats.
Topics: Animals; Diabetes Mellitus, Type 2; Embryonic and Fetal Development; Female; Fetal Diseases; Fetus; | 1997 |
Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Diabetes Mellitus, Type 2; Eukaryotic Cells; Gluc | 1998 |
Preserved initiatory and potentiatory effect of alpha-ketoisocaproate on insulin release in islets of glucose intolerant rats.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Crosses, Genetic; Diabetes Mellitus, Type 2; | 1998 |
Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats.
Topics: Alleles; Animals; Crosses, Genetic; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Gl | 2001 |
Abnormalities of insulin responses after ambient and previous exposure to glucose in streptozocin-diabetic and dexamethasone-treated rats. Role of hyperglycemia and increased B-cell demands.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Dexamethasone; Diabetes Mellitus, Experimental; | 1986 |