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2-keto-4-methylvalerate and Diabetes Mellitus, Type 2

2-keto-4-methylvalerate has been researched along with Diabetes Mellitus, Type 2 in 14 studies

alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.

Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Research Excerpts

ExcerptRelevanceReference
"77 patients with NAFLD and 11 healthy control subjects were studied."1.48The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the ( Afolabi, PR; Almehmadi, AA; Byrne, CD; Calder, PC; Scorletti, E; Smith, DE, 2018)
"HMF (cPDR over 1 h) was lower in NAFLD compared to controls [13."1.48The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the ( Afolabi, PR; Almehmadi, AA; Byrne, CD; Calder, PC; Scorletti, E; Smith, DE, 2018)
"Ageing and type 2 diabetes mellitus (T2DM) are risk factors for skeletal muscle loss."1.46Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity. ( Babraj, J; Cuthbertson, DJ; Leese, G; Siervo, M, 2017)
"Most patients at risk for developing type 2 diabetes are hyperinsulinemic."1.33Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. ( Attie, AD; Frey, BL; Gray-Keller, MP; Rabaglia, ME; Shortreed, MR; Smith, LM, 2005)
"In several rodent models of type 2 diabetes mellitus, GKAs lowered blood glucose levels, improved the results of glucose tolerance tests, and increased hepatic glucose uptake."1.32Allosteric activators of glucokinase: potential role in diabetes therapy. ( Bizzarro, FT; Chu, CA; Coffey, JW; Corbett, WL; Dvorozniak, MT; Grimsby, J; Grippo, JF; Guertin, KR; Haynes, NE; Hilliard, DW; Kester, RF; Magnuson, MA; Mahaney, PE; Marcus, L; Matschinsky, FM; Qi, L; Sarabu, R; Spence, CL; Tengi, J, 2003)
"Congenic strains for the two subloci (Niddm1f and Niddm1i) have been generated by transfer of GK alleles onto the genome of F344 rats."1.31Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats. ( Bergsten, P; Fakhrai-Rad, H; Galli, J; Lin, JM; Luthman, H; Ortsäter, H, 2001)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19901 (7.14)18.7374
1990's4 (28.57)18.2507
2000's6 (42.86)29.6817
2010's3 (21.43)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Afolabi, PR1
Scorletti, E1
Smith, DE1
Almehmadi, AA1
Calder, PC1
Byrne, CD1
Stec, DF1
Wang, S1
Stothers, C1
Avance, J1
Denson, D1
Harris, R1
Voziyan, P1
Cuthbertson, DJ1
Babraj, J1
Leese, G1
Siervo, M1
Grimsby, J1
Sarabu, R1
Corbett, WL1
Haynes, NE1
Bizzarro, FT1
Coffey, JW1
Guertin, KR1
Hilliard, DW1
Kester, RF1
Mahaney, PE1
Marcus, L1
Qi, L1
Spence, CL1
Tengi, J1
Magnuson, MA1
Chu, CA1
Dvorozniak, MT1
Matschinsky, FM1
Grippo, JF1
Rabaglia, ME1
Gray-Keller, MP1
Frey, BL1
Shortreed, MR1
Smith, LM1
Attie, AD1
Gustavsson, N1
Larsson-Nyrén, G1
Lindström, P1
Gunawardana, SC1
Head, WS1
Piston, DW1
Lugli, AK1
Donatelli, F1
Schricker, T1
Wykes, L1
Carli, F1
Tsuura, Y1
Ishida, H1
Okamoto, Y1
Kato, S1
Sakamoto, K1
Horie, M1
Ikeda, H1
Okada, Y1
Seino, Y1
Malaisse-Lagae, F1
Vanhoutte, C1
Rypens, F1
Louryan, S1
Malaisse, WJ1
Sakura, H1
Ashcroft, SJ1
Terauchi, Y1
Kadowaki, T1
Ashcroft, FM1
Guenifi, A1
Abdel-Halim, SM1
Efendic, S1
Ostenson, CG1
Lin, JM1
Ortsäter, H1
Fakhrai-Rad, H1
Galli, J1
Luthman, H1
Bergsten, P1
Grill, V1
Rundfeldt, M1

Trials

1 trial available for 2-keto-4-methylvalerate and Diabetes Mellitus, Type 2

ArticleYear
Epidural analgesia enhances the postoperative anabolic effect of amino acids in diabetes mellitus type 2 patients undergoing colon surgery.
    Anesthesiology, 2008, Volume: 108, Issue:6

    Topics: Aged; Amino Acids; Analgesia, Epidural; Analgesia, Patient-Controlled; Analgesics, Opioid; Blood Glu

2008

Other Studies

13 other studies available for 2-keto-4-methylvalerate and Diabetes Mellitus, Type 2

ArticleYear
The characterisation of hepatic mitochondrial function in patients with non-alcoholic fatty liver disease (NAFLD) using the
    Journal of breath research, 2018, 07-19, Volume: 12, Issue:4

    Topics: Adult; Breath Tests; Carbon Isotopes; Case-Control Studies; Diabetes Mellitus, Type 2; Female; Human

2018
Alterations of urinary metabolite profile in model diabetic nephropathy.
    Biochemical and biophysical research communications, 2015, Jan-09, Volume: 456, Issue:2

    Topics: Aconitic Acid; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitu

2015
Anabolic resistance does not explain sarcopenia in patients with type 2 diabetes mellitus, compared with healthy controls, despite reduced mTOR pathway activity.
    Clinical nutrition (Edinburgh, Scotland), 2017, Volume: 36, Issue:6

    Topics: Absorptiometry, Photon; Adaptor Proteins, Signal Transducing; Aged; Amino Acids, Essential; Anabolic

2017
Allosteric activators of glucokinase: potential role in diabetes therapy.
    Science (New York, N.Y.), 2003, Jul-18, Volume: 301, Issue:5631

    Topics: Adaptor Proteins, Signal Transducing; Allosteric Regulation; Animals; Blood Glucose; Carrier Protein

2003
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.
    American journal of physiology. Endocrinology and metabolism, 2005, Volume: 289, Issue:2

    Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutamate Dehydrogenase

2005
Pancreatic beta cells from db/db mice show cell-specific [Ca2+]i and NADH responses to glucose but not to alpha-ketoisocaproic acid.
    Pancreas, 2005, Volume: 31, Issue:3

    Topics: Animals; Body Weight; Calcium; Diabetes Mellitus, Type 2; Glucose; Glycolysis; In Vitro Techniques;

2005
Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes.
    American journal of physiology. Endocrinology and metabolism, 2008, Volume: 294, Issue:6

    Topics: Amiloride; Amino Acids, Cyclic; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Disease

2008
Glucose sensitivity of ATP-sensitive K+ channels is impaired in beta-cells of the GK rat. A new genetic model of NIDDM.
    Diabetes, 1993, Volume: 42, Issue:10

    Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism, Inborn Errors;

1993
Anomalies of fetal development in GK rats.
    Acta diabetologica, 1997, Volume: 34, Issue:2

    Topics: Animals; Diabetes Mellitus, Type 2; Embryonic and Fetal Development; Female; Fetal Diseases; Fetus;

1997
Glucose modulation of ATP-sensitive K-currents in wild-type, homozygous and heterozygous glucokinase knock-out mice.
    Diabetologia, 1998, Volume: 41, Issue:6

    Topics: Adenosine Triphosphate; Animals; Animals, Newborn; Diabetes Mellitus, Type 2; Eukaryotic Cells; Gluc

1998
Preserved initiatory and potentiatory effect of alpha-ketoisocaproate on insulin release in islets of glucose intolerant rats.
    Diabetologia, 1998, Volume: 41, Issue:11

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Cells, Cultured; Crosses, Genetic; Diabetes Mellitus, Type 2;

1998
Phenotyping of individual pancreatic islets locates genetic defects in stimulus secretion coupling to Niddm1i within the major diabetes locus in GK rats.
    Diabetes, 2001, Volume: 50, Issue:12

    Topics: Alleles; Animals; Crosses, Genetic; Diabetes Mellitus, Type 2; Genetic Predisposition to Disease; Gl

2001
Abnormalities of insulin responses after ambient and previous exposure to glucose in streptozocin-diabetic and dexamethasone-treated rats. Role of hyperglycemia and increased B-cell demands.
    Diabetes, 1986, Volume: 35, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Glucose; Dexamethasone; Diabetes Mellitus, Experimental;

1986