2-keto-4-methylvalerate has been researched along with Compensatory Hyperinsulinemia in 10 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose." | 3.69 | Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995) |
| "Most patients at risk for developing type 2 diabetes are hyperinsulinemic." | 1.33 | Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. ( Attie, AD; Frey, BL; Gray-Keller, MP; Rabaglia, ME; Shortreed, MR; Smith, LM, 2005) |
| "The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose." | 1.29 | Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995) |
| "During hyperinsulinemia (study 1), IDDUP showed a defective decrease of leucine (42% vs." | 1.29 | Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients. ( Battezzati, A; Bianchi, E; Ferrari, G; La Rocca, E; Luzi, L; Perseghin, G; Secchi, A; Spotti, D; Terruzzi, I; Vergani, S, 1994) |
| "The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were studied in postabsorptive healthy subjects with primed-constant infusions of L-[4,5-3H]leucine and [1-14C]alpha-ketoisocaproate (KIC) under euglycemic conditions." | 1.27 | Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition. ( Biolo, G; Crepaldi, G; Fantin, G; Inchiostro, S; Iori, E; Marescotti, MC; Tessari, P; Tiengo, A; Trevisan, R, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 6 (60.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rabaglia, ME | 1 |
| Gray-Keller, MP | 1 |
| Frey, BL | 1 |
| Shortreed, MR | 1 |
| Smith, LM | 1 |
| Attie, AD | 1 |
| Tauveron, I | 2 |
| Charrier, S | 1 |
| Champredon, C | 2 |
| Bonnet, Y | 1 |
| Berry, C | 2 |
| Bayle, G | 2 |
| Prugnaud, J | 2 |
| Obled, C | 1 |
| Grizard, J | 2 |
| Thiéblot, P | 2 |
| Battezzati, A | 2 |
| Terruzzi, I | 2 |
| Perseghin, G | 2 |
| Bianchi, E | 2 |
| Di Carlo, V | 1 |
| Pozza, G | 1 |
| Luzi, L | 3 |
| Petrides, AS | 1 |
| DeFronzo, RA | 1 |
| Spotti, D | 1 |
| Vergani, S | 1 |
| Secchi, A | 1 |
| La Rocca, E | 1 |
| Ferrari, G | 1 |
| Zhou, YP | 1 |
| Berggren, PO | 1 |
| Grill, V | 1 |
| Volpi, E | 1 |
| Lucidi, P | 1 |
| Cruciani, G | 1 |
| Monacchia, F | 1 |
| Reboldi, G | 1 |
| Brunetti, P | 1 |
| Bolli, GB | 1 |
| De Feo, P | 1 |
| Rochon, C | 1 |
| Dejax, C | 1 |
| Benoit, P | 1 |
| Capitan, P | 1 |
| Fabricio, A | 1 |
| Keller, U | 1 |
| Turkalj, I | 1 |
| Laager, R | 1 |
| Bloesch, D | 1 |
| Bilz, S | 1 |
| Tessari, P | 1 |
| Inchiostro, S | 1 |
| Biolo, G | 1 |
| Trevisan, R | 1 |
| Fantin, G | 1 |
| Marescotti, MC | 1 |
| Iori, E | 1 |
| Tiengo, A | 1 |
| Crepaldi, G | 1 |
1 trial available for 2-keto-4-methylvalerate and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Effects of medium- and long-chain fatty acids on whole body leucine and glucose kinetics in man.
Topics: Adult; C-Peptide; Carbon Isotopes; Fatty Acids; Fatty Acids, Nonesterified; Glucagon; Glucose; Gluco | 2002 |
9 other studies available for 2-keto-4-methylvalerate and Compensatory Hyperinsulinemia
| Article | Year |
|---|---|
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutamate Dehydrogenase | 2005 |
Response of leucine metabolism to hyperinsulinemia under amino acid replacement in experimental hyperthyroidism.
Topics: Adult; Amino Acids; Blood Glucose; Carbon Dioxide; Humans; Hyperinsulinism; Hyperthyroidism; Insulin | 1995 |
Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma.
Topics: Adult; Blood Glucose; Carbon Radioisotopes; Chronic Disease; Glucose; Glucose Clamp Technique; Human | 1995 |
Time-dependent regulation by insulin of leucine metabolism in young healthy adults.
Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Calorimetry, Indirect; Female; Glucagon; Humans; Hype | 1994 |
Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Hemoglobins; Hormones; Humans; Hyperinsulin | 1994 |
A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.
Topics: Aging; Animals; Carnitine O-Palmitoyltransferase; Cells, Cultured; Crosses, Genetic; Diabetes Mellit | 1996 |
Contribution of amino acids and insulin to protein anabolism during meal absorption.
Topics: Administration, Oral; Adult; Amino Acids; Antithrombin III; Blood Glucose; C-Peptide; Carbon Radiois | 1996 |
Response of leucine metabolism to hyperinsulinemia in hypothyroid patients before and after thyroxine replacement.
Topics: Adult; Amino Acids; Blood Glucose; Carbon Dioxide; Humans; Hyperinsulinism; Hypothyroidism; Insulin; | 2000 |
Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition.
Topics: Amino Acids; Blood Glucose; Carbon; Female; Glucagon; Humans; Hyperinsulinism; Insulin; Keto Acids; | 1987 |