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2-keto-4-methylvalerate and Compensatory Hyperinsulinemia

2-keto-4-methylvalerate has been researched along with Compensatory Hyperinsulinemia in 10 studies

alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.

Compensatory Hyperinsulinemia: A GLUCOSE-induced HYPERINSULINEMIA, a marker of insulin-resistant state. It is a mechanism to compensate for reduced sensitivity to insulin.

Research Excerpts

ExcerptRelevanceReference
"The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose."3.69Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995)
"Most patients at risk for developing type 2 diabetes are hyperinsulinemic."1.33Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice. ( Attie, AD; Frey, BL; Gray-Keller, MP; Rabaglia, ME; Shortreed, MR; Smith, LM, 2005)
"The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose."1.29Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995)
"During hyperinsulinemia (study 1), IDDUP showed a defective decrease of leucine (42% vs."1.29Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients. ( Battezzati, A; Bianchi, E; Ferrari, G; La Rocca, E; Luzi, L; Perseghin, G; Secchi, A; Spotti, D; Terruzzi, I; Vergani, S, 1994)
"The effects of physiologic hyperinsulinemia and hyperaminoacidemia, alone or in combination, on leucine kinetics in vivo were studied in postabsorptive healthy subjects with primed-constant infusions of L-[4,5-3H]leucine and [1-14C]alpha-ketoisocaproate (KIC) under euglycemic conditions."1.27Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition. ( Biolo, G; Crepaldi, G; Fantin, G; Inchiostro, S; Iori, E; Marescotti, MC; Tessari, P; Tiengo, A; Trevisan, R, 1987)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's6 (60.00)18.2507
2000's3 (30.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rabaglia, ME1
Gray-Keller, MP1
Frey, BL1
Shortreed, MR1
Smith, LM1
Attie, AD1
Tauveron, I2
Charrier, S1
Champredon, C2
Bonnet, Y1
Berry, C2
Bayle, G2
Prugnaud, J2
Obled, C1
Grizard, J2
ThiƩblot, P2
Battezzati, A2
Terruzzi, I2
Perseghin, G2
Bianchi, E2
Di Carlo, V1
Pozza, G1
Luzi, L3
Petrides, AS1
DeFronzo, RA1
Spotti, D1
Vergani, S1
Secchi, A1
La Rocca, E1
Ferrari, G1
Zhou, YP1
Berggren, PO1
Grill, V1
Volpi, E1
Lucidi, P1
Cruciani, G1
Monacchia, F1
Reboldi, G1
Brunetti, P1
Bolli, GB1
De Feo, P1
Rochon, C1
Dejax, C1
Benoit, P1
Capitan, P1
Fabricio, A1
Keller, U1
Turkalj, I1
Laager, R1
Bloesch, D1
Bilz, S1
Tessari, P1
Inchiostro, S1
Biolo, G1
Trevisan, R1
Fantin, G1
Marescotti, MC1
Iori, E1
Tiengo, A1
Crepaldi, G1

Trials

1 trial available for 2-keto-4-methylvalerate and Compensatory Hyperinsulinemia

ArticleYear
Effects of medium- and long-chain fatty acids on whole body leucine and glucose kinetics in man.
    Metabolism: clinical and experimental, 2002, Volume: 51, Issue:6

    Topics: Adult; C-Peptide; Carbon Isotopes; Fatty Acids; Fatty Acids, Nonesterified; Glucagon; Glucose; Gluco

2002

Other Studies

9 other studies available for 2-keto-4-methylvalerate and Compensatory Hyperinsulinemia

ArticleYear
Alpha-Ketoisocaproate-induced hypersecretion of insulin by islets from diabetes-susceptible mice.
    American journal of physiology. Endocrinology and metabolism, 2005, Volume: 289, Issue:2

    Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Disease Models, Animal; Glutamate Dehydrogenase

2005
Response of leucine metabolism to hyperinsulinemia under amino acid replacement in experimental hyperthyroidism.
    The American journal of physiology, 1995, Volume: 269, Issue:3 Pt 1

    Topics: Adult; Amino Acids; Blood Glucose; Carbon Dioxide; Humans; Hyperinsulinism; Hyperthyroidism; Insulin

1995
Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma.
    Diabetes, 1995, Volume: 44, Issue:7

    Topics: Adult; Blood Glucose; Carbon Radioisotopes; Chronic Disease; Glucose; Glucose Clamp Technique; Human

1995
Time-dependent regulation by insulin of leucine metabolism in young healthy adults.
    The American journal of physiology, 1994, Volume: 267, Issue:3 Pt 1

    Topics: Adolescent; Adult; Amino Acids; Blood Glucose; Calorimetry, Indirect; Female; Glucagon; Humans; Hype

1994
Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients.
    The Journal of clinical investigation, 1994, Volume: 93, Issue:5

    Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Hemoglobins; Hormones; Humans; Hyperinsulin

1994
A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.
    Diabetes, 1996, Volume: 45, Issue:5

    Topics: Aging; Animals; Carnitine O-Palmitoyltransferase; Cells, Cultured; Crosses, Genetic; Diabetes Mellit

1996
Contribution of amino acids and insulin to protein anabolism during meal absorption.
    Diabetes, 1996, Volume: 45, Issue:9

    Topics: Administration, Oral; Adult; Amino Acids; Antithrombin III; Blood Glucose; C-Peptide; Carbon Radiois

1996
Response of leucine metabolism to hyperinsulinemia in hypothyroid patients before and after thyroxine replacement.
    The Journal of clinical endocrinology and metabolism, 2000, Volume: 85, Issue:2

    Topics: Adult; Amino Acids; Blood Glucose; Carbon Dioxide; Humans; Hyperinsulinism; Hypothyroidism; Insulin;

2000
Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. Evidence for distinct mechanisms in regulation of net amino acid deposition.
    The Journal of clinical investigation, 1987, Volume: 79, Issue:4

    Topics: Amino Acids; Blood Glucose; Carbon; Female; Glucagon; Humans; Hyperinsulinism; Insulin; Keto Acids;

1987