2-keto-4-methylvalerate has been researched along with Chronic Kidney Failure in 13 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Inflammation is highly prevalent in chronic hemodialysis patients." | 1.31 | Inflammatory signals associated with hemodialysis. ( Caglar, K; Flakoll, PJ; Hakim, RM; Ikizler, TA; Levenhagen, D; Peng, Y; Pupim, LB, 2002) |
| "During hyperinsulinemia (study 1), IDDUP showed a defective decrease of leucine (42% vs." | 1.29 | Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients. ( Battezzati, A; Bianchi, E; Ferrari, G; La Rocca, E; Luzi, L; Perseghin, G; Secchi, A; Spotti, D; Terruzzi, I; Vergani, S, 1994) |
| "To see how chronic uremia affects R, 11/12 nephrectomized rats and sham-operated controls were fed a regular diet for 15 days and then given these isotopes p." | 1.27 | Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats. ( Kang, CW; Tungsanga, K; Walser, M, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 7 (53.85) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caglar, K | 1 |
| Peng, Y | 1 |
| Pupim, LB | 1 |
| Flakoll, PJ | 1 |
| Levenhagen, D | 1 |
| Hakim, RM | 1 |
| Ikizler, TA | 1 |
| Yang, H | 1 |
| Zheng, F | 1 |
| Jiang, J | 1 |
| Hu, P | 1 |
| Li, X | 1 |
| Schauder, P | 2 |
| Matthaei, D | 2 |
| Henning, HV | 1 |
| Scheler, F | 2 |
| Langenbeck, U | 2 |
| Oh, HY | 1 |
| Fadda, GZ | 1 |
| Smogorzewski, M | 1 |
| Liou, HH | 1 |
| Massry, SG | 1 |
| Luzi, L | 3 |
| Battezzati, A | 1 |
| Perseghin, G | 1 |
| Bianchi, E | 1 |
| Terruzzi, I | 1 |
| Spotti, D | 1 |
| Vergani, S | 1 |
| Secchi, A | 1 |
| La Rocca, E | 1 |
| Ferrari, G | 1 |
| Garibotto, G | 1 |
| Paoletti, E | 1 |
| Fiorini, F | 1 |
| Russo, R | 1 |
| Robaudo, C | 1 |
| Deferrari, G | 1 |
| Tizianello, A | 1 |
| Biolo, G | 1 |
| Toigo, G | 1 |
| Ciocchi, B | 1 |
| Morena, G | 1 |
| Situlin, R | 1 |
| Vasile, A | 1 |
| Carraro, M | 1 |
| Faccini, L | 1 |
| Guarnieri, G | 1 |
| Castellino, P | 2 |
| Giordano, M | 2 |
| Defronzo, RA | 2 |
| Kramer, P | 1 |
| Grieben, K | 1 |
| Mench-Hoinowski, A | 1 |
| Solini, A | 1 |
| Barr, JG | 1 |
| Smith, DJ | 1 |
| Petrides, A | 1 |
| Carroll, C | 1 |
| Barratt, TM | 1 |
| Chantler, C | 1 |
| Lederman, S | 1 |
| Rigden, SP | 1 |
| Tungsanga, K | 1 |
| Kang, CW | 1 |
| Walser, M | 1 |
| Bode, JC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Monocentric Prospective Randomized Pilot Study in Patients With Kidney Failure to Evaluate the Relationship Between the Hemadsorption During and After Cardiopulmonary Bypass and the Modulation of Post-surgical Inflammatory Response[NCT04157647] | 40 participants (Anticipated) | Interventional | 2020-11-15 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for 2-keto-4-methylvalerate and Chronic Kidney Failure
| Article | Year |
|---|---|
Effects of insulin and amino acids on glucose and leucine metabolism in CAPD patients.
Topics: Adult; Amino Acids; Blood Glucose; Calorimetry, Indirect; Female; Glucose; Hormones; Humans; Insulin | 1999 |
Assessment of renal function.
Topics: Adult; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Creatinine; Double-Blind Meth | 1986 |
11 other studies available for 2-keto-4-methylvalerate and Chronic Kidney Failure
| Article | Year |
|---|---|
Inflammatory signals associated with hemodialysis.
Topics: Adult; Biomarkers; Carbon Isotopes; Female; Fibrinogen; Humans; Inflammation; Interleukin-6; Keto Ac | 2002 |
[Plasma branched-chain ketoacids metabolism in patients with chronic renal failure after oral administration of ketosteril].
Topics: Administration, Oral; Adult; Amino Acids, Essential; Female; Hemiterpenes; Humans; Keto Acids; Kidne | 1999 |
Blood levels of branched-chain alpha-keto acids in uremia: effect of an oral glucose tolerance test.
Topics: Adult; Blood Glucose; C-Peptide; Female; Glucose Tolerance Test; Hemiterpenes; Humans; Insulin; Keto | 1981 |
Abnormal leucine-induced insulin secretion in chronic renal failure.
Topics: Animals; Body Weight; Bridged Bicyclo Compounds; Creatinine; Glutamate Dehydrogenase; Glutaminase; I | 1994 |
Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Hemoglobins; Hormones; Humans; Hyperinsulin | 1994 |
Peripheral metabolism of branched-chain keto acids in patients with chronic renal failure.
Topics: Adult; Amino Acids, Branched-Chain; Bicarbonates; Female; Hemiterpenes; Humans; Isoleucine; Keto Aci | 1993 |
Relationship between whole-body protein turnover and serum creatinine in chronically uremic patients.
Topics: Adult; Aged; Body Mass Index; Carbon Isotopes; Creatinine; Female; Humans; Hydrogen-Ion Concentratio | 1998 |
Plasma keto-analogues in uraemic patients.
Topics: Amino Acids; Creatinine; Hemiterpenes; Humans; Keto Acids; Kidney Failure, Chronic; Renal Dialysis; | 1979 |
Glucose and amino acid metabolism in chronic renal failure: effect of insulin and amino acids.
Topics: Adult; Amino Acids; Blood Glucose; Glucose; Hormones; Humans; Insulin; Keto Acids; Kidney Failure, C | 1992 |
Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats.
Topics: Animals; Blood Proteins; Body Weight; Keto Acids; Kidney Failure, Chronic; Leucine; Nephrectomy; Pro | 1986 |
[Branched-chain amino acids and their ketoanalogs: therapeutic uses in patients with chronic liver or kidney failure].
Topics: Administration, Oral; Amino Acids; Amino Acids, Branched-Chain; Amino Acids, Essential; Blood-Brain | 1985 |