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2-keto-4-methylvalerate and Chronic Disease

2-keto-4-methylvalerate has been researched along with Chronic Disease in 3 studies

alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.

Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effects of chronic metabolic acidosis on protein dynamics and amino acid oxidation in the human kidney, a combination of organ isotopic ((14)C-leucine) and mass-balance techniques in 11 subjects with normal renal function undergoing venous catheterizations was used."3.72Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis. ( Deferrari, G; Garibotto, G; Procopio, V; Robaudo, C; Russo, R; Saffioti, S; Sala, MR; Sofia, A; Tessari, P; Verzola, D; Vettore, M, 2004)
"The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose."3.69Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995)
"We measured leucine flux rates during infusions of L-[1-14C]- and L-[1-1C]leucine in fetal sheep exposed to maternal insulin-induced hypoglycemia over the last 8 wk (40%) of gestation to determine effects of chronic glucose deficiency and hypoglycemia on fetal leucine metabolism."3.69Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep. ( Carver, TD; Fennessey, PV; Hay, WW; Pike, AW; Quick, AA; Teng, CC, 1997)
"The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose."1.29Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995)

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (66.67)18.2507
2000's1 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Garibotto, G1
Sofia, A1
Robaudo, C1
Saffioti, S1
Sala, MR1
Verzola, D1
Vettore, M1
Russo, R1
Procopio, V1
Deferrari, G1
Tessari, P1
Battezzati, A1
Terruzzi, I1
Perseghin, G1
Bianchi, E1
Di Carlo, V1
Pozza, G1
Luzi, L1
Carver, TD1
Quick, AA1
Teng, CC1
Pike, AW1
Fennessey, PV1
Hay, WW1

Other Studies

3 other studies available for 2-keto-4-methylvalerate and Chronic Disease

ArticleYear
Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis.
    Journal of the American Society of Nephrology : JASN, 2004, Volume: 15, Issue:6

    Topics: Acidosis; Adult; Amino Acids; Ammonia; Catheterization; Chronic Disease; Female; Glomerular Filtrati

2004
Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma.
    Diabetes, 1995, Volume: 44, Issue:7

    Topics: Adult; Blood Glucose; Carbon Radioisotopes; Chronic Disease; Glucose; Glucose Clamp Technique; Human

1995
Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep.
    The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 1

    Topics: Animals; Blood Glucose; Body Weight; Carbon Isotopes; Chronic Disease; Female; Fetal Blood; Fetal Gr

1997