2-keto-4-methylvalerate has been researched along with Chronic Disease in 3 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effects of chronic metabolic acidosis on protein dynamics and amino acid oxidation in the human kidney, a combination of organ isotopic ((14)C-leucine) and mass-balance techniques in 11 subjects with normal renal function undergoing venous catheterizations was used." | 3.72 | Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis. ( Deferrari, G; Garibotto, G; Procopio, V; Robaudo, C; Russo, R; Saffioti, S; Sala, MR; Sofia, A; Tessari, P; Verzola, D; Vettore, M, 2004) |
| "The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose." | 3.69 | Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995) |
| "We measured leucine flux rates during infusions of L-[1-14C]- and L-[1-1C]leucine in fetal sheep exposed to maternal insulin-induced hypoglycemia over the last 8 wk (40%) of gestation to determine effects of chronic glucose deficiency and hypoglycemia on fetal leucine metabolism." | 3.69 | Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep. ( Carver, TD; Fennessey, PV; Hay, WW; Pike, AW; Quick, AA; Teng, CC, 1997) |
| "The ability of chronic endogenous hyperinsulinemia to induce a resistance to insulin action on protein and glucose metabolism was studied in 10 subjects affected by a benign (functioning) insulinoma and 18 healthy subjects by means of infusions of [1-(14)C]leucine and [3-(3)H] glucose." | 1.29 | Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma. ( Battezzati, A; Bianchi, E; Di Carlo, V; Luzi, L; Perseghin, G; Pozza, G; Terruzzi, I, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garibotto, G | 1 |
| Sofia, A | 1 |
| Robaudo, C | 1 |
| Saffioti, S | 1 |
| Sala, MR | 1 |
| Verzola, D | 1 |
| Vettore, M | 1 |
| Russo, R | 1 |
| Procopio, V | 1 |
| Deferrari, G | 1 |
| Tessari, P | 1 |
| Battezzati, A | 1 |
| Terruzzi, I | 1 |
| Perseghin, G | 1 |
| Bianchi, E | 1 |
| Di Carlo, V | 1 |
| Pozza, G | 1 |
| Luzi, L | 1 |
| Carver, TD | 1 |
| Quick, AA | 1 |
| Teng, CC | 1 |
| Pike, AW | 1 |
| Fennessey, PV | 1 |
| Hay, WW | 1 |
3 other studies available for 2-keto-4-methylvalerate and Chronic Disease
| Article | Year |
|---|---|
Kidney protein dynamics and ammoniagenesis in humans with chronic metabolic acidosis.
Topics: Acidosis; Adult; Amino Acids; Ammonia; Catheterization; Chronic Disease; Female; Glomerular Filtrati | 2004 |
Defective insulin action on protein and glucose metabolism during chronic hyperinsulinemia in subjects with benign insulinoma.
Topics: Adult; Blood Glucose; Carbon Radioisotopes; Chronic Disease; Glucose; Glucose Clamp Technique; Human | 1995 |
Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep.
Topics: Animals; Blood Glucose; Body Weight; Carbon Isotopes; Chronic Disease; Female; Fetal Blood; Fetal Gr | 1997 |