2-keto-4-methylvalerate has been researched along with Brain Edema in 1 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zinnanti, WJ | 1 |
| Lazovic, J | 1 |
| Griffin, K | 1 |
| Skvorak, KJ | 1 |
| Paul, HS | 1 |
| Homanics, GE | 1 |
| Bewley, MC | 1 |
| Cheng, KC | 1 |
| Lanoue, KF | 1 |
| Flanagan, JM | 1 |
1 other study available for 2-keto-4-methylvalerate and Brain Edema
| Article | Year |
|---|---|
Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease.
Topics: Amino Acids; Animals; Behavior, Animal; Brain; Brain Edema; Brain Mapping; Dietary Proteins; Disease | 2009 |