2-keto-4-methylvalerate has been researched along with Body Weight in 23 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Whole body leucine kinetics was compared in endurance-trained athletes and sedentary controls matched for age, gender, and body weight." | 5.09 | Comparison of leucine kinetics in endurance-trained and sedentary humans. ( Kalhan, SC; Lamont, LS; McCullough, AJ, 1999) |
| " While central leucine reduces food intake and body weight, the specific neuroanatomical sites of leucine sensing, downstream neural substrates, and neurochemical effectors involved in this regulation remain largely unknown." | 3.75 | Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. ( Blouet, C; Jo, YH; Li, X; Schwartz, GJ, 2009) |
| "We measured leucine flux rates during infusions of L-[1-14C]- and L-[1-1C]leucine in fetal sheep exposed to maternal insulin-induced hypoglycemia over the last 8 wk (40%) of gestation to determine effects of chronic glucose deficiency and hypoglycemia on fetal leucine metabolism." | 3.69 | Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep. ( Carver, TD; Fennessey, PV; Hay, WW; Pike, AW; Quick, AA; Teng, CC, 1997) |
| "Prednisone treatment causes protein wasting and adds additional risks to a patient, whereas human growth hormone (hGH) treatment causes positive nitrogen balance." | 2.67 | Human growth hormone prevents the protein catabolic side effects of prednisone in humans. ( Haymond, MW; Horber, FF, 1990) |
| "To see how chronic uremia affects R, 11/12 nephrectomized rats and sham-operated controls were fed a regular diet for 15 days and then given these isotopes p." | 1.27 | Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats. ( Kang, CW; Tungsanga, K; Walser, M, 1986) |
| " We also found that alpha-ketoisocaproate feeding at varying dosage did not alter this ratio in whole-body protein (measured in rats fasted overnight), suggesting that neither wide variations in growth rate nor exposure for 10 days to alpha-ketoisocaproate (in a diet of constant protein content) alters the relative rates of utilization (or oxidation) of alpha-ketoisocaproate vs." | 1.27 | Nutritional efficiency of alpha-ketoisocaproate relative to leucine, assessed isotopically. ( Kang, CW; Walser, M, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (39.13) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 6 (26.09) | 29.6817 |
| 2010's | 1 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shibata, K | 1 |
| Sakamoto, M | 1 |
| Blouet, C | 1 |
| Jo, YH | 1 |
| Li, X | 1 |
| Schwartz, GJ | 1 |
| Parra, D | 1 |
| González, A | 1 |
| Martínez, JA | 1 |
| Labayen, I | 1 |
| Díez, N | 1 |
| Gustavsson, N | 1 |
| Larsson-Nyrén, G | 1 |
| Lindström, P | 1 |
| Toth, MJ | 1 |
| Sites, CK | 1 |
| Matthews, DE | 1 |
| Fex, M | 1 |
| Nitert, MD | 1 |
| Wierup, N | 1 |
| Sundler, F | 1 |
| Ling, C | 1 |
| Mulder, H | 1 |
| Grill, V | 1 |
| Efendić, S | 1 |
| Yamada, O | 1 |
| Shin, M | 1 |
| Sano, K | 1 |
| Umezawa, C | 1 |
| Carbonnel, F | 1 |
| Messing, B | 1 |
| Darmaun, D | 1 |
| Rimbert, A | 1 |
| Rongier, M | 1 |
| Rigal, O | 1 |
| Koziet, J | 1 |
| Thuillier, F | 1 |
| Desjeux, JF | 1 |
| Oh, HY | 1 |
| Fadda, GZ | 1 |
| Smogorzewski, M | 1 |
| Liou, HH | 1 |
| Massry, SG | 1 |
| Tsuura, Y | 1 |
| Ishida, H | 1 |
| Okamoto, Y | 1 |
| Kato, S | 1 |
| Sakamoto, K | 1 |
| Horie, M | 1 |
| Ikeda, H | 1 |
| Okada, Y | 1 |
| Seino, Y | 1 |
| Carver, TD | 1 |
| Quick, AA | 1 |
| Teng, CC | 1 |
| Pike, AW | 1 |
| Fennessey, PV | 1 |
| Hay, WW | 1 |
| Holecek, M | 2 |
| Sprongl, L | 1 |
| Skopec, F | 1 |
| Andrýs, C | 1 |
| Pecka, M | 1 |
| Lamont, LS | 1 |
| McCullough, AJ | 1 |
| Kalhan, SC | 1 |
| Horber, FF | 1 |
| Haymond, MW | 1 |
| Funk, MA | 1 |
| Lowry, KR | 1 |
| Baker, DH | 1 |
| Yee, WC | 1 |
| Drachman, DB | 1 |
| Walser, M | 4 |
| Pestronk, A | 1 |
| Vazquez, JA | 1 |
| Paul, HS | 1 |
| Adibi, SA | 1 |
| Barratt, TM | 1 |
| Chantler, C | 1 |
| Lederman, S | 1 |
| Rigden, SP | 1 |
| Tungsanga, K | 2 |
| Kang, CW | 3 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot Study Examining the Impact of Eggs for Breakfast on Weight Loss and Hunger in Obese Children[NCT02467036] | 66 participants (Anticipated) | Interventional | 2014-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for 2-keto-4-methylvalerate and Body Weight
| Article | Year |
|---|---|
In vivo assessment of the mitochondrial response to caloric restriction in obese women by the 2-keto[1-C]isocaproate breath test.
Topics: Adolescent; Adult; Body Composition; Body Weight; Breath Tests; Caloric Restriction; Energy Metaboli | 2003 |
Role of ovarian hormones in the regulation of protein metabolism in women: effects of menopausal status and hormone replacement therapy.
Topics: Body Composition; Body Weight; Double-Blind Method; Estrogen Replacement Therapy; Estrogens, Conjuga | 2006 |
Comparison of leucine kinetics in endurance-trained and sedentary humans.
Topics: Adult; Blood Glucose; Body Composition; Body Weight; Female; Humans; Keto Acids; Leucine; Male; Oxyg | 1999 |
Human growth hormone prevents the protein catabolic side effects of prednisone in humans.
Topics: Blood Glucose; Body Weight; Diet; Growth Hormone; Humans; Insulin; Insulin-Like Growth Factor I; Ket | 1990 |
Assessment of renal function.
Topics: Adult; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Creatinine; Double-Blind Meth | 1986 |
18 other studies available for 2-keto-4-methylvalerate and Body Weight
| Article | Year |
|---|---|
Urinary Branched-Chain 2-Oxo Acids as a Biomarker for Function of B-Group Vitamins in Humans.
Topics: Asian People; Biomarkers; Body Mass Index; Body Weight; Dietary Carbohydrates; Dietary Fats; Dietary | 2016 |
Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit.
Topics: Animals; Anorexia; Body Weight; Bone Morphogenetic Protein Receptors, Type I; Brain Stem; Butadienes | 2009 |
Pancreatic beta cells from db/db mice show cell-specific [Ca2+]i and NADH responses to glucose but not to alpha-ketoisocaproic acid.
Topics: Animals; Body Weight; Calcium; Diabetes Mellitus, Type 2; Glucose; Glycolysis; In Vitro Techniques; | 2005 |
Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.
Topics: Adaptation, Physiological; Animals; Blood Glucose; Body Weight; Dietary Fats; Female; Glutamine; Ins | 2007 |
Abnormal D cell secretion in alloxan-diabetes: influence by drug and aberrant metabolism.
Topics: 1-Methyl-3-isobutylxanthine; Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experi | 1984 |
Effect of dietary excess leucine on the levels of branched chain alpha-keto acids and ketone bodies in blood and the liver of rats.
Topics: Animals; Body Weight; Diet; Hemiterpenes; Keto Acids; Ketone Bodies; Leucine; Liver; Male; NAD; Rats | 1983 |
Energy and protein metabolism in malnutrition due to nonneoplastic gastrointestinal diseases.
Topics: Body Mass Index; Body Weight; C-Reactive Protein; Calorimetry, Indirect; Energy Metabolism; Gastroin | 1995 |
Abnormal leucine-induced insulin secretion in chronic renal failure.
Topics: Animals; Body Weight; Bridged Bicyclo Compounds; Creatinine; Glutamate Dehydrogenase; Glutaminase; I | 1994 |
Glucose sensitivity of ATP-sensitive K+ channels is impaired in beta-cells of the GK rat. A new genetic model of NIDDM.
Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism, Inborn Errors; | 1993 |
Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep.
Topics: Animals; Blood Glucose; Body Weight; Carbon Isotopes; Chronic Disease; Female; Fetal Blood; Fetal Gr | 1997 |
Leucine metabolism in TNF-alpha- and endotoxin-treated rats: contribution of hepatic tissue.
Topics: Amino Acids; Animals; Body Weight; Carbon Radioisotopes; Endotoxins; Humans; Keto Acids; Leucine; Li | 1997 |
Effect of starvation on branched-chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle.
Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Body Weight; Heart; Keto Acids; Ketone O | 2001 |
Utilization of the L- and DL-isomers of alpha-keto-beta-methylvaleric acid by rats and comparative efficacy of the keto analogs of branched-chain amino acids provided as ornithine, lysine and histidine salts.
Topics: Amino Acids, Branched-Chain; Animals; Body Weight; Eating; Hemiterpenes; Histidine; Isoleucine; Keto | 1987 |
Effect of ketoleucine treatment on atrophy of skeletal muscle.
Topics: Animals; Body Weight; Female; Keto Acids; Methylhistidines; Muscle Denervation; Muscle Proteins; Mus | 1988 |
Leucine catabolism and incorporation into tissue proteins in thyroparathyroidectomized rats.
Topics: Animals; Body Weight; Keto Acids; Leucine; Liver; Male; Muscle Proteins; Muscles; Parathyroid Glands | 1988 |
Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats.
Topics: Animals; Blood Proteins; Body Weight; Keto Acids; Kidney Failure, Chronic; Leucine; Nephrectomy; Pro | 1986 |
Effect of the level of dietary protein on the utilization of alpha-ketoisocaproate for protein synthesis.
Topics: Administration, Oral; Animals; Body Weight; Carbon Radioisotopes; Dietary Proteins; Keto Acids; Leuc | 1986 |
Nutritional efficiency of alpha-ketoisocaproate relative to leucine, assessed isotopically.
Topics: Animals; Body Weight; Carbon Radioisotopes; Diet; Dose-Response Relationship, Drug; Eating; Fibrin; | 1985 |