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2-keto-4-methylvalerate and Body Weight

2-keto-4-methylvalerate has been researched along with Body Weight in 23 studies

alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.

Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Research Excerpts

ExcerptRelevanceReference
"Whole body leucine kinetics was compared in endurance-trained athletes and sedentary controls matched for age, gender, and body weight."5.09Comparison of leucine kinetics in endurance-trained and sedentary humans. ( Kalhan, SC; Lamont, LS; McCullough, AJ, 1999)
" While central leucine reduces food intake and body weight, the specific neuroanatomical sites of leucine sensing, downstream neural substrates, and neurochemical effectors involved in this regulation remain largely unknown."3.75Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit. ( Blouet, C; Jo, YH; Li, X; Schwartz, GJ, 2009)
"We measured leucine flux rates during infusions of L-[1-14C]- and L-[1-1C]leucine in fetal sheep exposed to maternal insulin-induced hypoglycemia over the last 8 wk (40%) of gestation to determine effects of chronic glucose deficiency and hypoglycemia on fetal leucine metabolism."3.69Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep. ( Carver, TD; Fennessey, PV; Hay, WW; Pike, AW; Quick, AA; Teng, CC, 1997)
"Prednisone treatment causes protein wasting and adds additional risks to a patient, whereas human growth hormone (hGH) treatment causes positive nitrogen balance."2.67Human growth hormone prevents the protein catabolic side effects of prednisone in humans. ( Haymond, MW; Horber, FF, 1990)
"To see how chronic uremia affects R, 11/12 nephrectomized rats and sham-operated controls were fed a regular diet for 15 days and then given these isotopes p."1.27Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats. ( Kang, CW; Tungsanga, K; Walser, M, 1986)
" We also found that alpha-ketoisocaproate feeding at varying dosage did not alter this ratio in whole-body protein (measured in rats fasted overnight), suggesting that neither wide variations in growth rate nor exposure for 10 days to alpha-ketoisocaproate (in a diet of constant protein content) alters the relative rates of utilization (or oxidation) of alpha-ketoisocaproate vs."1.27Nutritional efficiency of alpha-ketoisocaproate relative to leucine, assessed isotopically. ( Kang, CW; Walser, M, 1985)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19909 (39.13)18.7374
1990's7 (30.43)18.2507
2000's6 (26.09)29.6817
2010's1 (4.35)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shibata, K1
Sakamoto, M1
Blouet, C1
Jo, YH1
Li, X1
Schwartz, GJ1
Parra, D1
González, A1
Martínez, JA1
Labayen, I1
Díez, N1
Gustavsson, N1
Larsson-Nyrén, G1
Lindström, P1
Toth, MJ1
Sites, CK1
Matthews, DE1
Fex, M1
Nitert, MD1
Wierup, N1
Sundler, F1
Ling, C1
Mulder, H1
Grill, V1
Efendić, S1
Yamada, O1
Shin, M1
Sano, K1
Umezawa, C1
Carbonnel, F1
Messing, B1
Darmaun, D1
Rimbert, A1
Rongier, M1
Rigal, O1
Koziet, J1
Thuillier, F1
Desjeux, JF1
Oh, HY1
Fadda, GZ1
Smogorzewski, M1
Liou, HH1
Massry, SG1
Tsuura, Y1
Ishida, H1
Okamoto, Y1
Kato, S1
Sakamoto, K1
Horie, M1
Ikeda, H1
Okada, Y1
Seino, Y1
Carver, TD1
Quick, AA1
Teng, CC1
Pike, AW1
Fennessey, PV1
Hay, WW1
Holecek, M2
Sprongl, L1
Skopec, F1
Andrýs, C1
Pecka, M1
Lamont, LS1
McCullough, AJ1
Kalhan, SC1
Horber, FF1
Haymond, MW1
Funk, MA1
Lowry, KR1
Baker, DH1
Yee, WC1
Drachman, DB1
Walser, M4
Pestronk, A1
Vazquez, JA1
Paul, HS1
Adibi, SA1
Barratt, TM1
Chantler, C1
Lederman, S1
Rigden, SP1
Tungsanga, K2
Kang, CW3

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Pilot Study Examining the Impact of Eggs for Breakfast on Weight Loss and Hunger in Obese Children[NCT02467036]66 participants (Anticipated)Interventional2014-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

5 trials available for 2-keto-4-methylvalerate and Body Weight

ArticleYear
In vivo assessment of the mitochondrial response to caloric restriction in obese women by the 2-keto[1-C]isocaproate breath test.
    Metabolism: clinical and experimental, 2003, Volume: 52, Issue:4

    Topics: Adolescent; Adult; Body Composition; Body Weight; Breath Tests; Caloric Restriction; Energy Metaboli

2003
Role of ovarian hormones in the regulation of protein metabolism in women: effects of menopausal status and hormone replacement therapy.
    American journal of physiology. Endocrinology and metabolism, 2006, Volume: 291, Issue:3

    Topics: Body Composition; Body Weight; Double-Blind Method; Estrogen Replacement Therapy; Estrogens, Conjuga

2006
Comparison of leucine kinetics in endurance-trained and sedentary humans.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 86, Issue:1

    Topics: Adult; Blood Glucose; Body Composition; Body Weight; Female; Humans; Keto Acids; Leucine; Male; Oxyg

1999
Human growth hormone prevents the protein catabolic side effects of prednisone in humans.
    The Journal of clinical investigation, 1990, Volume: 86, Issue:1

    Topics: Blood Glucose; Body Weight; Diet; Growth Hormone; Humans; Insulin; Insulin-Like Growth Factor I; Ket

1990
Assessment of renal function.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 1986, Volume: 7, Issue:4

    Topics: Adult; Body Weight; Child; Child, Preschool; Clinical Trials as Topic; Creatinine; Double-Blind Meth

1986

Other Studies

18 other studies available for 2-keto-4-methylvalerate and Body Weight

ArticleYear
Urinary Branched-Chain 2-Oxo Acids as a Biomarker for Function of B-Group Vitamins in Humans.
    Journal of nutritional science and vitaminology, 2016, Volume: 62, Issue:4

    Topics: Asian People; Biomarkers; Body Mass Index; Body Weight; Dietary Carbohydrates; Dietary Fats; Dietary

2016
Mediobasal hypothalamic leucine sensing regulates food intake through activation of a hypothalamus-brainstem circuit.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009, Jul-01, Volume: 29, Issue:26

    Topics: Animals; Anorexia; Body Weight; Bone Morphogenetic Protein Receptors, Type I; Brain Stem; Butadienes

2009
Pancreatic beta cells from db/db mice show cell-specific [Ca2+]i and NADH responses to glucose but not to alpha-ketoisocaproic acid.
    Pancreas, 2005, Volume: 31, Issue:3

    Topics: Animals; Body Weight; Calcium; Diabetes Mellitus, Type 2; Glucose; Glycolysis; In Vitro Techniques;

2005
Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in islets from C57BL/6J mice fed a high-fat diet.
    Diabetologia, 2007, Volume: 50, Issue:1

    Topics: Adaptation, Physiological; Animals; Blood Glucose; Body Weight; Dietary Fats; Female; Glutamine; Ins

2007
Abnormal D cell secretion in alloxan-diabetes: influence by drug and aberrant metabolism.
    The American journal of physiology, 1984, Volume: 246, Issue:6 Pt 1

    Topics: 1-Methyl-3-isobutylxanthine; Alloxan; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experi

1984
Effect of dietary excess leucine on the levels of branched chain alpha-keto acids and ketone bodies in blood and the liver of rats.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 1983, Volume: 53, Issue:2

    Topics: Animals; Body Weight; Diet; Hemiterpenes; Keto Acids; Ketone Bodies; Leucine; Liver; Male; NAD; Rats

1983
Energy and protein metabolism in malnutrition due to nonneoplastic gastrointestinal diseases.
    Metabolism: clinical and experimental, 1995, Volume: 44, Issue:9

    Topics: Body Mass Index; Body Weight; C-Reactive Protein; Calorimetry, Indirect; Energy Metabolism; Gastroin

1995
Abnormal leucine-induced insulin secretion in chronic renal failure.
    The American journal of physiology, 1994, Volume: 267, Issue:5 Pt 2

    Topics: Animals; Body Weight; Bridged Bicyclo Compounds; Creatinine; Glutamate Dehydrogenase; Glutaminase; I

1994
Glucose sensitivity of ATP-sensitive K+ channels is impaired in beta-cells of the GK rat. A new genetic model of NIDDM.
    Diabetes, 1993, Volume: 42, Issue:10

    Topics: Adenosine Triphosphate; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism, Inborn Errors;

1993
Leucine metabolism in chronically hypoglycemic hypoinsulinemic growth-restricted fetal sheep.
    The American journal of physiology, 1997, Volume: 272, Issue:1 Pt 1

    Topics: Animals; Blood Glucose; Body Weight; Carbon Isotopes; Chronic Disease; Female; Fetal Blood; Fetal Gr

1997
Leucine metabolism in TNF-alpha- and endotoxin-treated rats: contribution of hepatic tissue.
    The American journal of physiology, 1997, Volume: 273, Issue:6

    Topics: Amino Acids; Animals; Body Weight; Carbon Radioisotopes; Endotoxins; Humans; Keto Acids; Leucine; Li

1997
Effect of starvation on branched-chain alpha-keto acid dehydrogenase activity in rat heart and skeletal muscle.
    Physiological research, 2001, Volume: 50, Issue:1

    Topics: 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); Animals; Body Weight; Heart; Keto Acids; Ketone O

2001
Utilization of the L- and DL-isomers of alpha-keto-beta-methylvaleric acid by rats and comparative efficacy of the keto analogs of branched-chain amino acids provided as ornithine, lysine and histidine salts.
    The Journal of nutrition, 1987, Volume: 117, Issue:9

    Topics: Amino Acids, Branched-Chain; Animals; Body Weight; Eating; Hemiterpenes; Histidine; Isoleucine; Keto

1987
Effect of ketoleucine treatment on atrophy of skeletal muscle.
    Experimental neurology, 1988, Volume: 99, Issue:1

    Topics: Animals; Body Weight; Female; Keto Acids; Methylhistidines; Muscle Denervation; Muscle Proteins; Mus

1988
Leucine catabolism and incorporation into tissue proteins in thyroparathyroidectomized rats.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1988, Volume: 187, Issue:1

    Topics: Animals; Body Weight; Keto Acids; Leucine; Liver; Male; Muscle Proteins; Muscles; Parathyroid Glands

1988
Utilization of alpha-ketoisocaproate for protein synthesis in uremic rats.
    Kidney international, 1986, Volume: 30, Issue:6

    Topics: Animals; Blood Proteins; Body Weight; Keto Acids; Kidney Failure, Chronic; Leucine; Nephrectomy; Pro

1986
Effect of the level of dietary protein on the utilization of alpha-ketoisocaproate for protein synthesis.
    The American journal of clinical nutrition, 1986, Volume: 43, Issue:4

    Topics: Administration, Oral; Animals; Body Weight; Carbon Radioisotopes; Dietary Proteins; Keto Acids; Leuc

1986
Nutritional efficiency of alpha-ketoisocaproate relative to leucine, assessed isotopically.
    The American journal of physiology, 1985, Volume: 249, Issue:4 Pt 1

    Topics: Animals; Body Weight; Carbon Radioisotopes; Diet; Dose-Response Relationship, Drug; Eating; Fibrin;

1985