2-keto-4-methylvalerate has been researched along with Autoimmune Diabetes in 9 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In summary, in IDDM: (a) Peripheral hyperinsulinemia is required to normalize both fasting leucine metabolism and blood glucose concentrations." | 5.27 | Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism. ( Biolo, G; Crepaldi, G; De Kreutzenberg, SV; Duner, E; Inchiostro, S; Marescotti, MC; Nosadini, R; Tessari, P; Tiengo, A; Trevisan, R, 1986) |
| "During hyperinsulinemia (study 1), IDDUP showed a defective decrease of leucine (42% vs." | 1.29 | Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients. ( Battezzati, A; Bianchi, E; Ferrari, G; La Rocca, E; Luzi, L; Perseghin, G; Secchi, A; Spotti, D; Terruzzi, I; Vergani, S, 1994) |
| "Thus, in IDDM subjects maintained at euglycemia, endogenous Ra of essential amino acid(s) (index of endogenous proteolysis) is increased, both in the postabsorptive state and after hyperinsulinemia combined with hyperaminoacidemia, while leucine utilization for protein synthesis is not impaired." | 1.28 | Effects of insulin and amino acid infusion on leucine and phenylalanine kinetics in type 1 diabetes. ( Biolo, G; Bruttomesso, D; Carlini, M; Duner, E; Fongher, C; Inchiostro, S; Sabadin, L; Tessari, P; Tiengo, A, 1992) |
| "We studied the metabolic adaptation of IDDM patients with early nephropathy to therapeutic, low-protein diets." | 1.28 | Effects of low-protein diets on protein metabolism in insulin-dependent diabetes mellitus patients with early nephropathy. ( Brodsky, IG; Devlin, JT; Fillyaw, M; Fuller, SP; Hiser, E; Robbins, DC, 1992) |
| "In summary, in IDDM: (a) Peripheral hyperinsulinemia is required to normalize both fasting leucine metabolism and blood glucose concentrations." | 1.27 | Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism. ( Biolo, G; Crepaldi, G; De Kreutzenberg, SV; Duner, E; Inchiostro, S; Marescotti, MC; Nosadini, R; Tessari, P; Tiengo, A; Trevisan, R, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 7 (77.78) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Stec, DF | 1 |
| Wang, S | 1 |
| Stothers, C | 1 |
| Avance, J | 1 |
| Denson, D | 1 |
| Harris, R | 1 |
| Voziyan, P | 1 |
| Luzi, L | 2 |
| Battezzati, A | 1 |
| Perseghin, G | 1 |
| Bianchi, E | 1 |
| Terruzzi, I | 1 |
| Spotti, D | 1 |
| Vergani, S | 1 |
| Secchi, A | 1 |
| La Rocca, E | 1 |
| Ferrari, G | 1 |
| Barazzoni, R | 1 |
| Meek, SE | 1 |
| Ekberg, K | 1 |
| Wahren, J | 1 |
| Nair, KS | 1 |
| Lin, JM | 1 |
| Sternesjö, J | 1 |
| Sandler, S | 1 |
| Bergsten, P | 1 |
| Inchiostro, S | 3 |
| Biolo, G | 3 |
| Bruttomesso, D | 1 |
| Fongher, C | 1 |
| Sabadin, L | 1 |
| Carlini, M | 1 |
| Duner, E | 2 |
| Tiengo, A | 3 |
| Tessari, P | 3 |
| Brodsky, IG | 1 |
| Robbins, DC | 1 |
| Hiser, E | 1 |
| Fuller, SP | 1 |
| Fillyaw, M | 1 |
| Devlin, JT | 1 |
| Saccà, L | 1 |
| Nosadini, R | 2 |
| Boscarato, MT | 1 |
| Trevisan, R | 2 |
| De Kreutzenberg, SV | 2 |
| Castellino, P | 1 |
| Simonson, DC | 1 |
| Petrides, AS | 1 |
| DeFronzo, RA | 1 |
| Marescotti, MC | 1 |
| Crepaldi, G | 1 |
1 trial available for 2-keto-4-methylvalerate and Autoimmune Diabetes
| Article | Year |
|---|---|
Arterial KIC as marker of liver and muscle intracellular leucine pools in healthy and type 1 diabetic humans.
Topics: Adult; Arteries; Diabetes Mellitus, Type 1; Female; Femoral Vein; Hepatic Veins; Humans; Insulin; Ke | 1999 |
8 other studies available for 2-keto-4-methylvalerate and Autoimmune Diabetes
| Article | Year |
|---|---|
Alterations of urinary metabolite profile in model diabetic nephropathy.
Topics: Aconitic Acid; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitu | 2015 |
Combined pancreas and kidney transplantation normalizes protein metabolism in insulin-dependent diabetic-uremic patients.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Female; Hemoglobins; Hormones; Humans; Hyperinsulin | 1994 |
Preserved pulsatile insulin release from prediabetic mouse islets.
Topics: Aging; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucose; In Vitr | 1999 |
Effects of insulin and amino acid infusion on leucine and phenylalanine kinetics in type 1 diabetes.
Topics: Amino Acids; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucagon; Glucose Clamp Technique; Hu | 1992 |
Effects of low-protein diets on protein metabolism in insulin-dependent diabetes mellitus patients with early nephropathy.
Topics: Adult; Amino Acids, Branched-Chain; Blood Proteins; Body Composition; Diabetes Mellitus, Type 1; Dia | 1992 |
Effects of insulin on whole body and forearm leucine and KIC metabolism in type 1 diabetes.
Topics: Adult; Blood Glucose; Caproates; Diabetes Mellitus, Type 1; Fatty Acids, Nonesterified; Forearm; Hum | 1990 |
Leucine metabolism in IDDM. Role of insulin and substrate availability.
Topics: Adult; Blood Glucose; Diabetes Mellitus, Type 1; Dose-Response Relationship, Drug; Epinephrine; Fema | 1990 |
Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism.
Topics: Adult; Amino Acids; Blood Glucose; Carbon; Diabetes Mellitus, Type 1; Humans; Insulin; Insulin Resis | 1986 |