2-keto-4-methylvalerate has been researched along with Aging in 12 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In order to approach the effect of preeclampsia in the mother on neonatal protein turnover, we studied the leucine turnover in preterm infants soon after birth and again after 7 days." | 5.31 | Effect of preeclampsia in the mother on the leucine metabolism in the newborn infant. ( Lotgering, FK; Saenz De Pipaón Marcos, M; Sauer, PJ; Van Beek, RH; Wattimena, DJ, 2002) |
| "A strong association has been reported between atherosclerotic diseases and fibrinogen levels, and a decreased whole body protein synthesis has also been reported with aging." | 3.70 | Age effect on fibrinogen and albumin synthesis in humans. ( Fu, A; Nair, KS, 1998) |
| "In order to approach the effect of preeclampsia in the mother on neonatal protein turnover, we studied the leucine turnover in preterm infants soon after birth and again after 7 days." | 1.31 | Effect of preeclampsia in the mother on the leucine metabolism in the newborn infant. ( Lotgering, FK; Saenz De Pipaón Marcos, M; Sauer, PJ; Van Beek, RH; Wattimena, DJ, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (58.33) | 18.2507 |
| 2000's | 4 (33.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Shreeram, S | 1 |
| Ramesh, S | 1 |
| Puthan, JK | 1 |
| Balakrishnan, G | 1 |
| Subramanian, R | 1 |
| Reddy, MT | 1 |
| Pereira, SL | 1 |
| Cuthbertson, D | 1 |
| Smith, K | 1 |
| Babraj, J | 1 |
| Leese, G | 1 |
| Waddell, T | 1 |
| Atherton, P | 1 |
| Wackerhage, H | 1 |
| Taylor, PM | 1 |
| Rennie, MJ | 1 |
| Laychock, SG | 1 |
| Vadlamudi, S | 1 |
| Patel, MS | 1 |
| Bombara, M | 3 |
| Masiello, P | 3 |
| Novelli, M | 3 |
| Bergamini, E | 3 |
| Gatnau, R | 1 |
| Zimmerman, DR | 1 |
| Nissen, SL | 1 |
| Wannemuehler, M | 1 |
| Ewan, RC | 1 |
| Zhou, YP | 1 |
| Berggren, PO | 1 |
| Grill, V | 1 |
| Fu, A | 1 |
| Nair, KS | 1 |
| Lin, JM | 1 |
| Sternesjö, J | 1 |
| Sandler, S | 1 |
| Bergsten, P | 1 |
| Hasten, DL | 1 |
| Pak-Loduca, J | 1 |
| Obert, KA | 1 |
| Yarasheski, KE | 1 |
| De Tata, V | 1 |
| Saenz De Pipaón Marcos, M | 1 |
| Wattimena, DJ | 1 |
| Van Beek, RH | 1 |
| Lotgering, FK | 1 |
| Sauer, PJ | 1 |
| Fierabracci, V | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Deep Nutritional Phenotyping of Adult Crohn's Disease Patients: a Focus on Protein Intake and Sarcopenia[NCT05572203] | 35 participants (Anticipated) | Interventional | 2022-04-14 | Active, not recruiting | |||
| Community Ambulation Project (CAP) Ancillary Study - PUSH Plus Protein Pilot Study[NCT03410823] | 20 participants (Actual) | Interventional | 2018-07-16 | Active, not recruiting | |||
| Hormonal Regulators of Muscle and Metabolism in Aging[NCT00183040] | Phase 2 | 108 participants (Anticipated) | Interventional | 2002-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for 2-keto-4-methylvalerate and Aging
| Article | Year |
|---|---|
Resistance exercise acutely increases MHC and mixed muscle protein synthesis rates in 78-84 and 23-32 yr olds.
Topics: Actins; Adult; Aged; Aged, 80 and over; Aging; Body Composition; Female; Humans; Keto Acids; Kinetic | 2000 |
11 other studies available for 2-keto-4-methylvalerate and Aging
| Article | Year |
|---|---|
Age associated decline in the conversion of leucine to β-Hydroxy-β-Methylbutyrate in rats.
Topics: 4-Hydroxyphenylpyruvate Dioxygenase; Aging; Animals; Dietary Supplements; Humans; Keto Acids; Leucin | 2016 |
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.
Topics: Adult; Aged; Aging; Amino Acids, Essential; Carbon Isotopes; Drinking; Drug Resistance; Eukaryotic I | 2005 |
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.
Topics: Adult; Aged; Aging; Amino Acids, Essential; Carbon Isotopes; Drinking; Drug Resistance; Eukaryotic I | 2005 |
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.
Topics: Adult; Aged; Aging; Amino Acids, Essential; Carbon Isotopes; Drinking; Drug Resistance; Eukaryotic I | 2005 |
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle.
Topics: Adult; Aged; Aging; Amino Acids, Essential; Carbon Isotopes; Drinking; Drug Resistance; Eukaryotic I | 2005 |
Neonatal rat dietary carbohydrate affects pancreatic islet insulin secretion in adults and progeny.
Topics: Aging; Animals; Animals, Newborn; Dietary Carbohydrates; Female; Glucose; Glyceraldehyde-3-Phosphate | 1995 |
Impairment of the priming effect of glucose on insulin secretion from isolated islets of aging rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Arginine; Blood Glucose; Glucose; In Vitro Techniques; | 1995 |
Effects of excess dietary leucine and leucine catabolites on growth and immune responses in weanling pigs.
Topics: 3-Hydroxybutyric Acid; Aging; Amino Acids; Animals; Avena; Blood Urea Nitrogen; Crosses, Genetic; De | 1995 |
A fatty acid-induced decrease in pyruvate dehydrogenase activity is an important determinant of beta-cell dysfunction in the obese diabetic db/db mouse.
Topics: Aging; Animals; Carnitine O-Palmitoyltransferase; Cells, Cultured; Crosses, Genetic; Diabetes Mellit | 1996 |
Age effect on fibrinogen and albumin synthesis in humans.
Topics: Adult; Aged; Aging; Female; Fibrinogen; Humans; Keto Acids; Leucine; Male; Middle Aged; Osmolar Conc | 1998 |
Preserved pulsatile insulin release from prediabetic mouse islets.
Topics: Aging; Animals; Animals, Newborn; Blood Glucose; Diabetes Mellitus, Type 1; Female; Glucose; In Vitr | 1999 |
Age-dependent reduction in GLUT-2 levels is correlated with the impairment of the insulin secretory response in isolated islets of Sprague-Dawley rats.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Glucose Transporter Type 2; Insulin; Insulin Secretion; | 2000 |
Effect of preeclampsia in the mother on the leucine metabolism in the newborn infant.
Topics: Aging; Birth Weight; Carbon Isotopes; Dietary Proteins; Energy Intake; Female; Gestational Age; Huma | 2002 |
Effects of different regimens of dietary restriction on the age-related decline in insulin secretory response of isolated rat pancreatic islets.
Topics: 1-Methyl-3-isobutylxanthine; Aging; Animals; Arginine; Diet, Reducing; Energy Intake; Glucose; In Vi | 1991 |