2-keto-4-methylvalerate has been researched along with Adenoma, Islet Cell in 3 studies
alpha-ketoisocaproic acid: RN given refers to parent cpd
4-methyl-2-oxopentanoate : A 2-oxo monocarboxylic acid anion that is the conjugate base of 4-methyl-2-oxopentanoic acid.
4-methyl-2-oxopentanoic acid : A 2-oxo monocarboxylic acid that is pentanoic acid (valeric acid) substituted with a keto group at C-2 and a methyl group at C-4. A metabolite that has been found to accumulate in maple syrup urine disease.
Adenoma, Islet Cell: A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We studied the release of insulin, glucagon, and somatostatin in response to glucose, glyceraldehyde (GA), and alpha-ketoisocaproate (KIC) from rat kidneys containing transplanted insulinomas." | 3.67 | Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984) |
| "Cytochalasin B did not enhance this primed glucose response." | 1.27 | Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984) |
| "These findings show that this islet cell tumor transplanted under the kidney capsule releases insulin in response to physiologic and model fuel substances." | 1.27 | Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney. ( Ferguson, DC; Hoenig, M; Matschinsky, FM, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hoenig, M | 1 |
| Ferguson, DC | 1 |
| Matschinsky, FM | 1 |
| Barreto, M | 1 |
| Sener, A | 2 |
| Malaisse, WJ | 2 |
| Valverde, I | 1 |
| Leclercq-Meyer, V | 1 |
| Marchand, J | 1 |
| Blachier, F | 1 |
3 other studies available for 2-keto-4-methylvalerate and Adenoma, Islet Cell
| Article | Year |
|---|---|
Fuel-induced insulin release in vitro from insulinomas transplanted into the rat kidney.
Topics: Adenoma, Islet Cell; Animals; Cytochalasin B; Diazoxide; Glucagon; Glucose; Glyceraldehyde; Humans; | 1984 |
Inhibition by a nonmetabolized analogue of L-leucine of protein biosynthesis in tumoral pancreatic islet cells.
Topics: Adenoma, Islet Cell; Amino Acids; Amino Acids, Cyclic; Keto Acids; Leucine; Neoplasm Proteins; Pancr | 1989 |
Effects of L-leucine, its 2-keto acid metabolite and its non-metabolized analogue on rat tumoral islet cell function.
Topics: Adenine Nucleotides; Adenoma, Islet Cell; Amino Acids; Amino Acids, Cyclic; Animals; Calcium Radiois | 1988 |