2-iminobiotin has been researched along with Anoxia-Ischemia, Brain in 13 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (61.54) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| de Leede, LGJ; Hartstra, J; Leufkens, PWTJ; Peeters-Scholte, CMPCD; van Hoogdalem, EJ; van Lier, JJ | 1 |
| Albrecht, M; Groenendaal, F; Peeters-Scholte, C; van Bel, F; Zitta, K | 1 |
| Juul, SE; McAdams, RM | 1 |
| Albrecht, M; Parczany, K; Peeters-Scholte, C; Sommer, L; Steinfath, M; Zitta, K | 1 |
| Bjorkman, ST; Colditz, PB; Fan, X; Ireland, Z; Peeters-Scholte, CM; Roes, KC; van der Wal, WM | 1 |
| Bär, D; Blomgren, K; Groenendaal, F; Hagberg, H; Kops, N; Koster, J; Nicolay, K; Peeters-Scholte, C; van Bel, F; van Buul-Offers, S; van den Tweel, E; Veldhuis, W; Zhu, C | 1 |
| Braun, K; Groenendaal, F; Ioroi, T; Nicolay, K; Peeters-Scholte, C; Post, I; van Bel, F; van den Tweel, E; Veldhuis, W | 1 |
| Blomgren, K; Groenendaal, F; Hagberg, H; Hamers, N; Heijnen, C; Koster, J; Peeters-Scholte, C; van Bel, F; van Buul-Offers, S; van den Tweel, E; Zhu, C | 1 |
| Groenendaal, F; Peeters-Scholte, C; van Bel, F; van den Tweel, E | 1 |
| Blomgren, K; Hagberg, H; Peeters-Scholte, C; Qiu, L; Wang, X; Zhu, C | 1 |
| Groenendaal, F; Haumann, J; Heijnen, CJ; Kavelaars, A; Nijboer, CH; Peeters-Scholte, CM; van Bel, F; van den Tweel, ER | 1 |
| Groenendaal, F; Hagberg, HH; Heijnen, CJ; Kavelaars, A; Nijboer, CH; van Bel, F | 1 |
| Groenendaal, F; Heijnen, CJ; Kavelaars, A; Nijboer, CH; van Bel, F | 1 |
2 review(s) available for 2-iminobiotin and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
Neuroprotective strategies following perinatal hypoxia-ischemia: Taking aim at NOS.
Topics: Allopurinol; Asphyxia Neonatorum; Biotin; Cerebral Palsy; Clinical Trials as Topic; Epilepsy; Erythropoietin; Female; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Intellectual Disability; Ischemic Postconditioning; Melatonin; Neuroprotective Agents; Pregnancy; Reactive Nitrogen Species; Reactive Oxygen Species | 2019 |
Neonatal Encephalopathy: Update on Therapeutic Hypothermia and Other Novel Therapeutics.
Topics: Anesthetics, Inhalation; Biotin; Central Nervous System Depressants; Cerebral Palsy; Constriction; Erythropoietin; Humans; Hypothermia, Induced; Hypoxia-Ischemia, Brain; Infant, Newborn; Intellectual Disability; Melatonin; Stem Cell Transplantation; Survival Rate; Umbilical Cord; Xenon | 2016 |
1 trial(s) available for 2-iminobiotin and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
First-in-Human Study of the Safety, Tolerability, Pharmacokinetics and - Preliminary Dynamics of Neuroprotectant 2-Iminobiotin in Healthy Subjects.
Topics: Adolescent; Adult; beta-Cyclodextrins; Biotin; Dose-Response Relationship, Drug; Double-Blind Method; Excipients; Humans; Hypoxia-Ischemia, Brain; Infusions, Intravenous; Male; Middle Aged; Neuroprotective Agents; Time Factors; Tissue Distribution; Young Adult | 2020 |
10 other study(ies) available for 2-iminobiotin and Anoxia-Ischemia, Brain
| Article | Year |
|---|---|
Insights into the neuroprotective mechanisms of 2-iminobiotin employing an in-vitro model of hypoxic-ischemic cell injury.
Topics: Biotin; Cell Line; Dose-Response Relationship, Drug; Gene Expression Regulation; Humans; Hypoxia-Ischemia, Brain; Neurons; Neuroprotective Agents; Oxidative Stress | 2016 |
Short-term dose-response characteristics of 2-iminobiotin immediately postinsult in the neonatal piglet after hypoxia-ischemia.
Topics: Animals; Asphyxia; Biotin; Brain; Caspase 3; Dose-Response Relationship, Drug; Electroencephalography; Hypoxia-Ischemia, Brain; Models, Animal; Nitric Oxide Synthase; Swine; Time Factors; Treatment Outcome | 2013 |
Neuroprotection by selective nitric oxide synthase inhibition at 24 hours after perinatal hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Apoptosis; Biotin; Brain; Brain Edema; Caspase 3; Caspases; Disease Models, Animal; Energy Metabolism; Enzyme Inhibitors; Hypoxia-Ischemia, Brain; Immunohistochemistry; In Situ Nick-End Labeling; Magnetic Resonance Spectroscopy; Neuroprotective Agents; Nitric Oxide Synthase; Reperfusion Injury; Survival Rate; Swine; Treatment Outcome; Tyrosine | 2002 |
Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective.
Topics: Allopurinol; Animals; Animals, Newborn; Biotin; Cerebral Cortex; Deferoxamine; Electroencephalography; Enzyme Inhibitors; Free Radical Scavengers; Hemoglobins; Hypoxia-Ischemia, Brain; Iron Chelating Agents; Magnetic Resonance Spectroscopy; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phosphorus Radioisotopes; Spectrophotometry; Swine; Time Factors | 2002 |
Effects of selective nitric oxide synthase inhibition on IGF-1, caspases and cytokines in a newborn piglet model of perinatal hypoxia-ischaemia.
Topics: Animals; Animals, Newborn; Biotin; Brain; Caspases; Cytokines; DNA Fragmentation; Enzyme Activation; Enzyme Inhibitors; Hypoxia-Ischemia, Brain; In Situ Nick-End Labeling; Insulin-Like Growth Factor I; Models, Animal; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Primed In Situ Labeling; RNA, Messenger; Swine | 2002 |
Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig.
Topics: Allopurinol; Animals; Animals, Newborn; Biotin; Brain; Cell Survival; Deferoxamine; Disease Models, Animal; Disease Progression; Electron Transport Complex IV; Energy Metabolism; Free Radical Scavengers; Hypoxia-Ischemia, Brain; Iron Chelating Agents; Magnetic Resonance Spectroscopy; Neurons; Neuroprotective Agents; Oxidation-Reduction; Phosphates; Phosphocreatine; Predictive Value of Tests; Spectroscopy, Near-Infrared; Swine | 2004 |
Nitrosylation precedes caspase-3 activation and translocation of apoptosis-inducing factor in neonatal rat cerebral hypoxia-ischaemia.
Topics: Animals; Animals, Newborn; Apoptosis Inducing Factor; Biomarkers; Biotin; Caspase 3; Caspases; Cell Count; Disease Models, Animal; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Female; Flavoproteins; Hypoxia-Ischemia, Brain; Male; Membrane Proteins; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Protein Transport; Rats; Rats, Wistar; Tyrosine | 2004 |
Long-term neuroprotection with 2-iminobiotin, an inhibitor of neuronal and inducible nitric oxide synthase, after cerebral hypoxia-ischemia in neonatal rats.
Topics: Animals; Animals, Newborn; Biotin; Brain Chemistry; Cytochromes c; Female; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Male; Neuroprotective Agents; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxidation-Reduction; Rats; Rats, Wistar; Tyrosine | 2005 |
Gender-specific neuroprotection by 2-iminobiotin after hypoxia-ischemia in the neonatal rat via a nitric oxide independent pathway.
Topics: Animals; Animals, Newborn; Biotin; Blotting, Western; Caspases; Enzyme Inhibitors; Female; Guanidines; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; omega-N-Methylarginine; Pregnancy; Rats; Rats, Wistar; Sex Characteristics; Signal Transduction; Tyrosine | 2007 |
Gender-dependent pathways of hypoxia-ischemia-induced cell death and neuroprotection in the immature P3 rat.
Topics: Aging; Animals; Animals, Newborn; Biotin; Birth Injuries; Brain; Cell Death; Cytochromes c; Cytoprotection; Disease Models, Animal; Female; HSP70 Heat-Shock Proteins; Hypoxia-Ischemia, Brain; Male; Mitochondria; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Wistar; Sex Characteristics; Time; Treatment Outcome | 2007 |