2-hydroxysaclofen has been researched along with Muscle Contraction in 5 studies
2-hydroxysaclofen: structure given in first source
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "2-hydroxy-saclofen (2-OH-S), a sulphonic analogue of baclofen, slightly increased the twitch height and reversibly antagonised the GABA- and baclofen-induced depression of twitch contractions in the guinea pig vas deferens and isolated ileum, causing a parallel dextral shift in the baclofen dose-response curve in a competitive manner (pA2 = 5." | 1.27 | 2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors. ( Abbenante, J; Johnston, GA; Kerr, DI; Ong, J; Prager, RH, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kerr, DI | 4 |
| Humeniuk, RE | 1 |
| Ong, J | 4 |
| Doolette, DJ | 1 |
| Schafer, K | 1 |
| Prager, RH | 3 |
| Chen, TF | 1 |
| Doyle, PT | 1 |
| Ferguson, DR | 1 |
| Johnston, GA | 2 |
| Abbenante, J | 2 |
5 other studies available for 2-hydroxysaclofen and Muscle Contraction
| Article | Year |
|---|---|
Gamma-guanidinobaclofen is a peripheral GABAB receptor agonist.
Topics: Animals; Baclofen; Cerebral Cortex; Corpus Callosum; Dose-Response Relationship, Drug; Electrophysio | 1994 |
The (S)-enantiomer of 2-hydroxysaclofen is the active GABAB receptor antagonist in central and peripheral preparations.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Guinea Pigs; Hippocampus; Ileum; Male; Membrane | 1995 |
Inhibitory role of gamma-amino-butyric acid in the rabbit urinary bladder.
Topics: Animals; Baclofen; Bicuculline; Carbachol; Depression, Chemical; Dose-Response Relationship, Drug; G | 1992 |
Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA.
Topics: Animals; Baclofen; Cerebral Cortex; Evoked Potentials; GABA-A Receptor Antagonists; gamma-Aminobutyr | 1989 |
2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors.
Topics: Action Potentials; Animals; Baclofen; Cerebral Cortex; Ileum; In Vitro Techniques; Male; Motor Neuro | 1988 |