2-hydroxysaclofen has been researched along with Disease Models, Animal in 5 studies
2-hydroxysaclofen: structure given in first source
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC), measured by the elevated plus maze, were abolished by 2-OH-saclofen (GABAB receptor antagonist) (1 mg/kg; ip) or the lack of GABAB receptors (GABAB1 knockout mice)." | 7.80 | Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches. ( Balerio, GN; Bettler, B; Pedrón, VT; Varani, AP, 2014) |
| "Previous studies from our laboratory showed that anxiety-related responses induced by nicotine (NIC), measured by the elevated plus maze, were abolished by 2-OH-saclofen (GABAB receptor antagonist) (1 mg/kg; ip) or the lack of GABAB receptors (GABAB1 knockout mice)." | 3.80 | Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches. ( Balerio, GN; Bettler, B; Pedrón, VT; Varani, AP, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Varani, AP | 1 |
| Pedrón, VT | 1 |
| Bettler, B | 1 |
| Balerio, GN | 1 |
| Miranda, F | 1 |
| Jiménez, JC | 1 |
| Cedillo, LN | 1 |
| Sandoval-Sánchez, A | 1 |
| Millán-Mejía, P | 1 |
| Sánchez-Castillo, H | 1 |
| Velázquez-Martínez, DN | 1 |
| Hosford, DA | 1 |
| Clark, S | 1 |
| Cao, Z | 1 |
| Wilson, WA | 1 |
| Lin, FH | 1 |
| Morrisett, RA | 1 |
| Huin, A | 1 |
5 other studies available for 2-hydroxysaclofen and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Involvement of GABAB receptors in biochemical alterations induced by anxiety-related responses to nicotine in mice: genetic and pharmacological approaches.
Topics: Analysis of Variance; Animals; Anxiety; Baclofen; Disease Models, Animal; Dorsal Raphe Nucleus; Dose | 2014 |
The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure.
Topics: Animals; Baclofen; Central Nervous System Stimulants; Conditioning, Psychological; Dextroamphetamine | 2009 |
The role of GABAB receptor activation in absence seizures of lethargic (lh/lh) mice.
Topics: Animals; Anticonvulsants; Baclofen; Disease Models, Animal; Dose-Response Relationship, Drug; Electr | 1992 |