2-hydroxyestrone and Obesity

2-hydroxyestrone has been researched along with Obesity* in 1 studies

Trials

1 trial(s) available for 2-hydroxyestrone and Obesity

Article	Year
Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol. International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1998, Volume: 22, Issue:3 To investigate whether the dietary phytochemical, indole-3-carbinol (13C), influences the level of estradiol 2-hydroxylation in obese women.. A clinical intervention study involving the ingestion of purified 13C, 400 mg, for two months.. Five healthy, overweight, premenopausal women (age: 35-47 y, body mass index (BMI): 27-53 kg/m2).. Two estrogen metabolites, 2-hydroxyestrone (2OHE1) and estriol (E3), were measured by radioimmunoassay in untimed overnight urine samples, before and after ingestion of 13C.. The ratio of urinary estrogens, 2OHE1/E3, was significantly increased in obese women following 13C, reflecting induction of 2-hydroxylation in these women.. Obese premenopausal women experience increased estrogen 2-hydroxylation in response to the dietary agent, 13C, similar to non-obese women. This response to 13C may result in a hormonal milieu that helps reduce estrogen-dependent cancer risk. Topics: Administration, Oral; Adult; Antioxidants; Cohort Studies; Estradiol; Estriol; Estrogen Antagonists; Female; Humans; Hydroxyestrones; Hydroxylation; Indoles; Middle Aged; Obesity; Premenopause	1998

Article

Year

Increased estrogen 2-hydroxylation in obese women using oral indole-3-carbinol.

International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1998, Volume: 22, Issue:3

To investigate whether the dietary phytochemical, indole-3-carbinol (13C), influences the level of estradiol 2-hydroxylation in obese women.. A clinical intervention study involving the ingestion of purified 13C, 400 mg, for two months.. Five healthy, overweight, premenopausal women (age: 35-47 y, body mass index (BMI): 27-53 kg/m2).. Two estrogen metabolites, 2-hydroxyestrone (2OHE1) and estriol (E3), were measured by radioimmunoassay in untimed overnight urine samples, before and after ingestion of 13C.. The ratio of urinary estrogens, 2OHE1/E3, was significantly increased in obese women following 13C, reflecting induction of 2-hydroxylation in these women.. Obese premenopausal women experience increased estrogen 2-hydroxylation in response to the dietary agent, 13C, similar to non-obese women. This response to 13C may result in a hormonal milieu that helps reduce estrogen-dependent cancer risk.

Topics: Administration, Oral; Adult; Antioxidants; Cohort Studies; Estradiol; Estriol; Estrogen Antagonists; Female; Humans; Hydroxyestrones; Hydroxylation; Indoles; Middle Aged; Obesity; Premenopause

1998