2-hydroxyestrone and Diabetes--Gestational

2-hydroxyestrone has been researched along with Diabetes--Gestational* in 1 studies

Other Studies

1 other study(ies) available for 2-hydroxyestrone and Diabetes--Gestational

Article	Year
Establishment and validation of a sensitive LC-MS/MS method for quantification of urinary estrogens in women with gestational diabetes mellitus. Journal of pharmaceutical and biomedical analysis, 2022, Nov-30, Volume: 221 Gestational diabetes mellitus (GDM) is not only a threat to the health of pregnant women, but also has profound effects on the health of offspring. Studies have shown that the imbalance of estrogen metabolism is associated with an increased risk of GDM. In this study, an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established and validated for simultaneous quantification of thirteen estrogens in the urine of GDM women, including estrone (E1), estradiol (E2), estriol (E3), and their hydroxylated and methylated metabolites. The method was achieved on a Waters CORTECS C18 column (2.1 mm × 150 mm, 1.6 µm) within 8.5 min. The linear range of thirteen estrogens in urine was 2-1000 pg·mL Topics: Chromatography, Liquid; Creatinine; Diabetes, Gestational; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Hydroxyestrones; Pregnancy; Tandem Mass Spectrometry	2022

Article

Year

Establishment and validation of a sensitive LC-MS/MS method for quantification of urinary estrogens in women with gestational diabetes mellitus.

Journal of pharmaceutical and biomedical analysis, 2022, Nov-30, Volume: 221

Gestational diabetes mellitus (GDM) is not only a threat to the health of pregnant women, but also has profound effects on the health of offspring. Studies have shown that the imbalance of estrogen metabolism is associated with an increased risk of GDM. In this study, an ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established and validated for simultaneous quantification of thirteen estrogens in the urine of GDM women, including estrone (E1), estradiol (E2), estriol (E3), and their hydroxylated and methylated metabolites. The method was achieved on a Waters CORTECS C18 column (2.1 mm × 150 mm, 1.6 µm) within 8.5 min. The linear range of thirteen estrogens in urine was 2-1000 pg·mL

Topics: Chromatography, Liquid; Creatinine; Diabetes, Gestational; Estradiol; Estriol; Estrogens; Estrone; Female; Humans; Hydroxyestrones; Pregnancy; Tandem Mass Spectrometry

2022