2-fluoro-2-deoxyglucose-6-phosphate and Carcinoma--Non-Small-Cell-Lung

Radiofrequency ablation (RFA) for thoracic tumours has emerged as a minimally invasive therapy option for primary and secondary lung tumours and has gained increasing acceptance for pain palliation. The procedure is well tolerated and the complication rates are low. RFA provides the opportunity for localized tissue destruction of limited tumour volumes with medium and long term follow-up data suggesting that survival figures do parallel those of non-surgical treatment modalities. The purpose of this article is to review the status of RFA in lung tumours, to emphasize its place in symptomatic palliation and to discuss its potential role in conjunction with radiation or systemic therapy.

Topics: Carcinoma, Non-Small-Cell Lung; Catheter Ablation; Colorectal Neoplasms; Combined Modality Therapy; Glucose-6-Phosphate; Hemorrhage; Humans; Lung Neoplasms; Palliative Care; Patient Selection; Pleural Effusion; Pleural Neoplasms; Pneumothorax; Prognosis; Tomography, X-Ray Computed; Treatment Outcome

Integrated computed tomography-positron emission tomography (CT-PET) scanners improve localization of regions of increased [18F]-fluoro-2-deoxy-D-glucose (FDG) uptake and staging accuracy by allowing the near-simultaneous acquisition of coregistered, spatially matched functional and morphologic data in the same examination. However, many benign lesions can accumulate FDG and be potential pitfalls in interpretation. With the increased use of CT-PET in oncologic imaging, misinterpretation of these potential pitfalls can have significant clinical ramifications and alter staging and management. In this article, we review the physiologic uptake of FDG, normal variants, and potential pitfalls in the integrated CT-PET imaging of the thorax and their implications in oncologic imaging.

Topics: Artifacts; Carcinoma, Non-Small-Cell Lung; Glucose-6-Phosphate; Humans; Hyperventilation; Image Processing, Computer-Assisted; Lung Neoplasms; Magnetic Resonance Imaging; Muscle, Skeletal; Pleurodesis; Positron-Emission Tomography; Respiration; Respiratory Muscles; Thoracic Neoplasms; Tomography, X-Ray Computed

The routine use of integrated positron emission tomography computed tomography in the staging and follow-up of patients diagnosed with non-small-cell lung cancer has improved diagnostic accuracy but many incidental extrathoracic findings are routinely encountered. These include physiologic fluorodeoxy glucose avid foci, normal computed tomography variants, and second primary malignancies, all of which have to be differentiated from extrathoracic metastatic disease. Knowledge of these findings is important for correct staging and identification of second primaries.

Topics: Adipose Tissue; Bone Marrow; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Glucose-6-Phosphate; Head and Neck Neoplasms; Humans; Lymphatic Metastasis; Positron-Emission Tomography; Thoracic Neoplasms; Thyroid Gland; Tomography, X-Ray Computed; Vocal Cord Paralysis