Compounds > 2-deoxyribose-1-phosphate--(alpha-d-erythro)-isomer

2-deoxyribose-1-phosphate--(alpha-d-erythro)-isomer and HIV-Infections

2-deoxyribose-1-phosphate--(alpha-d-erythro)-isomer has been researched along with HIV-Infections* in 1 studies

Other Studies

1 other study(ies) available for 2-deoxyribose-1-phosphate--(alpha-d-erythro)-isomer and HIV-Infections

Article	Year
Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads. Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4 2-Deoxy-α-d-ribose-1-phosphate is of great interest as it is involved in the biosynthesis and/or catabolic degradation of several nucleoside analogues of biological and therapeutic relevance. However due to the lack of a stabilising group at its 2-position, it is difficult to synthesize stable prodrugs of this compound. In order to overcome this lack of stability, the synthesis of carbasugar analogues of 2-deoxyribose-1-phosphate was envisioned. Herein the preparation of a series of prodrugs of two carbocyclic analogues of 2-deoxyribose-1-phosphate using the phosphoramidate ProTide technology, along with their biological evaluation against HIV and cancer cell proliferation, is reported. Topics: Amides; Anti-HIV Agents; Antineoplastic Agents; Carbasugars; Cell Line, Tumor; HIV; HIV Infections; Humans; Neoplasms; Phosphoric Acids; Prodrugs; Ribosemonophosphates	2015

Article

Year

Synthesis and biological evaluation of phosphoramidate prodrugs of two analogues of 2-deoxy-d-ribose-1-phosphate directed to the discovery of two carbasugars as new potential anti-HIV leads.

Bioorganic & medicinal chemistry, 2015, Feb-15, Volume: 23, Issue:4

2-Deoxy-α-d-ribose-1-phosphate is of great interest as it is involved in the biosynthesis and/or catabolic degradation of several nucleoside analogues of biological and therapeutic relevance. However due to the lack of a stabilising group at its 2-position, it is difficult to synthesize stable prodrugs of this compound. In order to overcome this lack of stability, the synthesis of carbasugar analogues of 2-deoxyribose-1-phosphate was envisioned. Herein the preparation of a series of prodrugs of two carbocyclic analogues of 2-deoxyribose-1-phosphate using the phosphoramidate ProTide technology, along with their biological evaluation against HIV and cancer cell proliferation, is reported.

Topics: Amides; Anti-HIV Agents; Antineoplastic Agents; Carbasugars; Cell Line, Tumor; HIV; HIV Infections; Humans; Neoplasms; Phosphoric Acids; Prodrugs; Ribosemonophosphates

2015