2-cyanobenzothiazole and Neoplasms

2-cyanobenzothiazole has been researched along with Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for 2-cyanobenzothiazole and Neoplasms

Article	Year
Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance. Angewandte Chemie (International ed. in English), 2015, Aug-10, Volume: 54, Issue:33 Multidrug resistance (MDR) remains the biggest challenge in treating cancers. Herein we propose the intracellular self-assembly of nanodrugs as a new strategy for overcoming MDR. By employing a biocompatible condensation reaction, we rationally designed a taxol derivative Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(taxol)-2-cyanobenzothiazole (CBT-Taxol) which could be subjected to furin-controlled condensation and self-assembly of taxol nanoparticles (Taxol-NPs). In vitro and in vivo studies indicated that, compared with taxol, CBT-Taxol showed a 4.5-fold or 1.5-fold increase in anti-MDR effects, respectively, on taxol-resistant HCT 116 cancer cells or tumors without being toxic to the cells or the mice. Our results demonstrate that structuring protease-susceptible agents and assembling them intracellularly into nanodrugs could be a new optimal strategy for overcoming MDR. Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Benzothiazoles; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HCT116 Cells; Humans; Mice, Nude; Nanoparticles; Neoplasms; Nitriles; Paclitaxel	2015

Article

Year

Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance.

Angewandte Chemie (International ed. in English), 2015, Aug-10, Volume: 54, Issue:33

Multidrug resistance (MDR) remains the biggest challenge in treating cancers. Herein we propose the intracellular self-assembly of nanodrugs as a new strategy for overcoming MDR. By employing a biocompatible condensation reaction, we rationally designed a taxol derivative Ac-Arg-Val-Arg-Arg-Cys(StBu)-Lys(taxol)-2-cyanobenzothiazole (CBT-Taxol) which could be subjected to furin-controlled condensation and self-assembly of taxol nanoparticles (Taxol-NPs). In vitro and in vivo studies indicated that, compared with taxol, CBT-Taxol showed a 4.5-fold or 1.5-fold increase in anti-MDR effects, respectively, on taxol-resistant HCT 116 cancer cells or tumors without being toxic to the cells or the mice. Our results demonstrate that structuring protease-susceptible agents and assembling them intracellularly into nanodrugs could be a new optimal strategy for overcoming MDR.

Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Benzothiazoles; Drug Resistance, Multiple; Drug Resistance, Neoplasm; HCT116 Cells; Humans; Mice, Nude; Nanoparticles; Neoplasms; Nitriles; Paclitaxel

2015