2-chloro-n(6)-(3-iodobenzyl)adenosine-5--n-methyluronamide and Glaucoma

Glaucoma is a progressive chronic retinal degenerative disease and a leading cause of global irreversible blindness, characterized by optic nerve damage and retinal ganglion cell (RGC) death. Elevated intraocular pressure (IOP) is a main risk factor of glaucoma. Neuroinflammation plays an important role in glaucoma. We have been demonstrating that elevated pressure triggers microglia reactivity that contribute to the loss of RGCs. Adenosine, acting on adenosine receptors, is a crucial modulator of microglia phenotype. Microglia express all adenosine receptors. Previously, we demonstrated that the activation of adenosine A

Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Cell Death; Cell Movement; Cell Proliferation; Glaucoma; Humans; Intraocular Pressure; Microglia; Optic Nerve; Optic Nerve Injuries; Phagocytosis; Rats; Receptor, Adenosine A3; Retinal Degeneration; Retinal Ganglion Cells