Compounds > 2-chloro-6-(2-furyl)-9-(4-methoxyphenylmethyl)-9h-purine

2-chloro-6-(2-furyl)-9-(4-methoxyphenylmethyl)-9h-purine and Tuberculosis

2-chloro-6-(2-furyl)-9-(4-methoxyphenylmethyl)-9h-purine has been researched along with Tuberculosis* in 1 studies

Other Studies

1 other study(ies) available for 2-chloro-6-(2-furyl)-9-(4-methoxyphenylmethyl)-9h-purine and Tuberculosis

ArticleYear
Synthesis, structure, and antimycobacterial activity of 6-[1(3H)-isobenzofuranylidenemethyl]purines and analogs.
    Bioorganic & medicinal chemistry, 2009, Sep-15, Volume: 17, Issue:18

    6-Benzofuryl-, styryl, benzyl, and furfurylpurines as well as 6-[1(3H)-isobenzofuranylidenemethyl]purines have been synthesized and their activities against Mycobacterium tuberculosis (Mtb) determined. Several compounds displayed profound antimycobacterial activity in combination with low toxicity towards mammalian cells. NMR and X-ray crystallography were employed to determine the detailed structures and the results were supported by quantum chemical calculations.

    Topics: Animals; Antitubercular Agents; Cell Survival; Chlorocebus aethiops; Crystallography, X-Ray; Microbial Sensitivity Tests; Models, Molecular; Mycobacterium tuberculosis; Purines; Structure-Activity Relationship; Tuberculosis; Vero Cells

2009