Compounds > 2-chloro-4--6--dimethoxy-2--hydroxychalcone

2-chloro-4--6--dimethoxy-2--hydroxychalcone and Drug-Related-Side-Effects-and-Adverse-Reactions

2-chloro-4--6--dimethoxy-2--hydroxychalcone has been researched along with Drug-Related-Side-Effects-and-Adverse-Reactions* in 1 studies

Other Studies

1 other study(ies) available for 2-chloro-4--6--dimethoxy-2--hydroxychalcone and Drug-Related-Side-Effects-and-Adverse-Reactions

Article	Year
Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship. Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7 A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation. Topics: Animals; Antimitotic Agents; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chalcones; Drug Screening Assays, Antitumor; Drug-Related Side Effects and Adverse Reactions; Humans; Mice; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Survival Rate	2008

Article

Year

Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship.

Journal of medicinal chemistry, 2008, Apr-10, Volume: 51, Issue:7

A series of 59 chalcones was prepared and evaluated for the antimitotic effect against K562 leukemia cells. The most active chalcones were evaluated for their antiproliferative activity against a panel of 11 human and murine cell cancer lines. We found that three chalcones were of great interest as potential antimitotic drugs. In vivo safety studies conducted on one of the most active chalcones revealed that the compound was safe, allowing further in vivo antitumor evaluation.

Topics: Animals; Antimitotic Agents; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Chalcones; Drug Screening Assays, Antitumor; Drug-Related Side Effects and Adverse Reactions; Humans; Mice; Molecular Structure; Stereoisomerism; Structure-Activity Relationship; Survival Rate

2008