2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane and Pneumonia--Viral

To report a case of a patient infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who acutely developed a hypokinetic-rigid syndrome.. Patient data were obtained from medical records from the Hospital Universitario 12 de Octubre in Madrid, Spain. [. We report a previously healthy 58-year-old man who developed hyposmia, generalized myoclonus, fluctuating and transient changes in level of consciousness, opsoclonus, and an asymmetric hypokinetic-rigid syndrome with ocular abnormalities after a severe SARS-CoV-2 infection. DaT-SPECT confirmed a bilateral decrease in presynaptic dopamine uptake asymmetrically involving both putamina. Significant improvement in the parkinsonian symptoms was observed without any specific treatment.. This case study provides clinical and functional neuroimaging evidence to support that SARS-CoV-2 can gain access to the CNS, affecting midbrain structures and leading to neurologic signs and symptoms.

Topics: Betacoronavirus; Brain; Consciousness Disorders; Coronavirus Infections; COVID-19; Disease Progression; Dopamine Plasma Membrane Transport Proteins; Electroencephalography; Humans; Hypokinesia; Magnetic Resonance Imaging; Male; Middle Aged; Muscle Rigidity; Nortropanes; Ocular Motility Disorders; Pandemics; Parkinson Disease, Postencephalitic; Pneumonia, Viral; Putamen; SARS-CoV-2; Tomography, Emission-Computed, Single-Photon