2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane and Pantothenate-Kinase-Associated-Neurodegeneration

We present a case of a 72-year-old man with a 9-year history of memory decline and 7-year history of parkinsonian symptoms. An MRI demonstrated an "eye-of-the-tiger" sign in the basal ganglia, suggestive of pantothenate kinase-associated neurodegeneration (formerly known as Hallervorden-Spatz syndrome). An 123I-ioflupane SPECT scan demonstrated absence of radiotracer uptake in the caudate nuclei and putamina. Genetic testing confirmed a single-point mutation in the PANK2 gene, consistent with pantothenate kinase-associated neurodegeneration.

Topics: Aged; Brain; Caudate Nucleus; Humans; Magnetic Resonance Imaging; Male; Nortropanes; Pantothenate Kinase-Associated Neurodegeneration; Putamen; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon