2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane and Irritable-Bowel-Syndrome

Gastrointestinal symptoms are common in Parkinson's disease (PD), but their neurophysiological correlates are not well understood. We recently reported that functional gastrointestinal symptoms were not associated with asymmetry per se but might be associated with lower left striatal dopamine transporter (DAT) binding. The purpose of this study was to further investigate if specific gastrointestinal symptoms associate with monoamine transporter changes in specific striatal or extrastriatal areas.. Ninety PD patients, who underwent DAT ¹. Irritable bowel syndrome (IBS) criteria were fulfilled in 17 patients and were linked to higher ¹. These findings suggest that PD patients with IBS may have higher DAT binding in the right hemisphere. This finding implicates alterations of brain neurotransmitter physiology in the gastrointestinal symptoms of PD patients.

Topics: Brain; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Humans; Irritable Bowel Syndrome; Parkinson Disease; Serotonin Plasma Membrane Transport Proteins