2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane and Cerebellar-Ataxia

The severity of parkinsonism and response to levodopa vary in patients with multiple system atrophy (MSA) because of the heterogeneity of nigrostriatal neuropathology.. To investigate the difference in clinical features between MSA patients with predominantly pre-synaptic nigrostriatal dysfunction and those with trans-synaptic nigrostriatal dysfunction.. Parkinsonian features were significantly more severe in the MSA-STR group than in the MSA-SNpc group (P = .005) and cerebellar ataxia was significantly more severe in the MSA-SNpc group (P = .036). The cerebellar type of MSA was significantly more common in the MSA-SNpc group (P = .001). There was no difference in age at onset, disease duration at the time of study, or Mini-Mental Status Examination scores between the groups.. Patients with MSA showed distinct clinical features depending on whether the pattern of nigrostriatal dysfunction was predominantly pre-synaptic or trans-synaptic.

Topics: Adult; Aged; Case-Control Studies; Cerebellar Ataxia; Corpus Striatum; Female; Fluorodeoxyglucose F18; Functional Neuroimaging; Humans; Male; Middle Aged; Multiple System Atrophy; Neural Pathways; Parkinsonian Disorders; Positron-Emission Tomography; Presynaptic Terminals; Putamen; Substantia Nigra; Tropanes

Topics: Aged; Cerebellar Ataxia; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Levodopa; Male; Middle Aged; Multiple System Atrophy; Positron-Emission Tomography; Tropanes