2-carbomethoxy-8-(3-fluoropropyl)-3-(4-iodophenyl)tropane and Atrophy

The specific binding ratio (SBR) is an objective indicator of N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-[123I] iodophenyl) nortropane ([

Topics: Atrophy; Biomarkers; Brain; Computer Simulation; Disease Progression; Dopamine Plasma Membrane Transport Proteins; Humans; Image Interpretation, Computer-Assisted; Lewy Body Disease; Monte Carlo Method; Neurodegenerative Diseases; Parkinson Disease; Predictive Value of Tests; Radiopharmaceuticals; Reproducibility of Results; Tomography, Emission-Computed, Single-Photon; Tropanes

Dopamine transporter (DAT) imaging such as. We studied 99 subjects, including 39 patients with Alzheimer's disease (AD), 15 patients with Parkinson's disease (PD) and 10 patients with dementia with Lewy bodies (DLB). Each subject had undergone. The SBR with TM was 0.53 percentage points lower than the SBR without TM overall (p < 0.01). Positive and negative reversal of AI increased with age. The rate of the SBR change with TM was tended to be lower in groups with brain atrophy. The number of voxels excluded by TM in striatal volumes of interest (VOIs) was larger with high groups for EI, SI and CAI than in low groups. The number of voxels excluded using TM in reference VOIs was related to SI.. The SBR was decreased using TM. The effect of TM on the SBR tended to be small in the subjects with severe brain atrophy. The effect of brain atrophy in the TM is larger in the striatal VOIs than in the reference VOIs. Even if quantitative analyses are available, visual assessment of

Topics: Aged; Aged, 80 and over; Atrophy; Brain; Dopamine Plasma Membrane Transport Proteins; Female; Humans; Image Processing, Computer-Assisted; Male; Middle Aged; Tomography, Emission-Computed, Single-Photon; Tropanes

Neuropsychiatric symptoms impact the patients' quality of life and caregivers' burdens in Parkinson's disease (PD). We aimed to investigate the effects of striatal dopaminergic depletion and brain atrophy on the neuropsychiatric symptoms of patients with PD.. Two hundred and seven patients with de novo drug-naïve PD underwent dopamine transporter (DAT) positron emission tomography and brain MRI scanning. In addition, the patients were assessed with caregiver-administered neuropsychiatric inventory (NPI) questionnaires. To evaluate the effects of DAT uptake, subcortical volume and cortical thinning on the patients' neuropsychiatric symptoms, we performed logistic regression and negative binomial regression analyses on the NPI data after controlling for possible confounders.. Frontal cortical thinning was associated with the presence of nighttime behaviour and irritability, and the thinning correlated with the severity of the nighttime behaviour. Temporal cortical thinning was associated with the presence of aggression/agitation, and it correlated with the severity of the aggression/agitation. Subcortical atrophy in the accumbens was associated with the presence of disinhibition and correlated with the severity of the disinhibition. Putamen atrophy and insular thinning were independently associated with the presence of apathy, but only insular thinning correlated with the severity of the apathy. Of the predictors, only frontal cortical thinning correlated with the total NPI score.. The results of this study suggested that accumbens atrophy and frontotemporal cortical thinning, especially frontal cortical thinning, independently contributed to neuropsychiatric symptoms in patients with PD, while DAT uptake did not affect the neuropsychiatric symptoms.

Topics: Aged; Aggression; Anxiety; Apathy; Appetite; Atrophy; Brain; Cerebral Cortex; Depression; Dopamine Plasma Membrane Transport Proteins; Female; Fluorine Radioisotopes; Humans; Inhibition, Psychological; Irritable Mood; Logistic Models; Magnetic Resonance Imaging; Male; Middle Aged; Nucleus Accumbens; Organ Size; Parkinson Disease; Positron-Emission Tomography; Tropanes

Topics: Aged; Atrophy; Cerebral Amyloid Angiopathy; Corpus Striatum; Humans; Iodine Radioisotopes; Male; Mesencephalon; Neuroimaging; Nortropanes; Parkinson Disease; Radionuclide Imaging; Supranuclear Palsy, Progressive

Topics: Atrophy; Cerebral Cortex; Female; Frontotemporal Dementia; Humans; Magnetic Resonance Imaging; Middle Aged; Positron-Emission Tomography; Tropanes

The authors studied four patients with parkinsonism carrying the fragile X premutation using SPECT with ([23)I]FP-CIT. They found evidence of preserved presynaptic nigrostriatal function, suggesting that parkinsonism in the X fragile premutation might be related to postsynaptic dopaminergic changes or different neurotransmitter alterations.

Topics: Aged; Atrophy; Biomarkers; Brain; Brain Mapping; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Female; Fragile X Syndrome; Genetic Predisposition to Disease; Heterozygote; Humans; Male; Middle Aged; Mutation; Neural Pathways; Parkinson Disease; Substantia Nigra; Synaptic Transmission; Syndrome; Tomography, Emission-Computed, Single-Photon; Tropanes