2-aminoethoxydiphenyl borate has been researched along with Alzheimer Disease in 3 studies
2-aminoethoxydiphenyl borate: is a novel membrane-penetrable modulator and transient receptor potential channel blocker; structure in first source; do not confuse with 2-APB cpd
2-aminoethoxydiphenylborane : An organoboron compound that is diphenylborane in which the borane hydrogen is replaced by a 2-aminoethoxy group.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The amyloid hypothesis of Alzheimer's disease (AD) suggests that soluble amyloid β (Aβ) is an initiator of a cascade of events eventually leading to neurodegeneration." | 1.39 | Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB. ( Aronica, E; Canonico, PL; Genazzani, AA; Grolla, AA; Iyer, A; Lim, D; Ronco, V, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ozaki, S | 1 |
| Suzuki, AZ | 1 |
| Bauer, PO | 1 |
| Ebisui, E | 1 |
| Mikoshiba, K | 1 |
| An, X | 1 |
| Fu, Z | 1 |
| Mai, C | 1 |
| Wang, W | 1 |
| Wei, L | 1 |
| Li, D | 1 |
| Li, C | 1 |
| Jiang, LH | 1 |
| Lim, D | 1 |
| Iyer, A | 1 |
| Ronco, V | 1 |
| Grolla, AA | 1 |
| Canonico, PL | 1 |
| Aronica, E | 1 |
| Genazzani, AA | 1 |
3 other studies available for 2-aminoethoxydiphenyl borate and Alzheimer Disease
| Article | Year |
|---|---|
2-Aminoethyl diphenylborinate (2-APB) analogues: regulation of Ca2+ signaling.
Topics: Alzheimer Disease; Animals; Boron Compounds; Calcium Signaling; CHO Cells; Cricetulus; Heart Disease | 2013 |
Increasing the TRPM2 Channel Expression in Human Neuroblastoma SH-SY5Y Cells Augments the Susceptibility to ROS-Induced Cell Death.
Topics: Alzheimer Disease; Boron Compounds; Cell Death; Cell Line, Tumor; Cell Survival; Humans; Hydrogen Pe | 2019 |
Amyloid beta deregulates astroglial mGluR5-mediated calcium signaling via calcineurin and Nf-kB.
Topics: Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Pepti | 2013 |