2-aminoadipic acid has been researched along with Seizures in 13 studies
2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).
2-aminoadipic acid : An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report treatment outcome of eleven patients with pyridoxine-dependent epilepsy caused by pathogenic variants in ALDH7A1 (PDE-ALDH7A1)." | 7.85 | Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy. ( Al Teneiji, A; Bruun, TU; Cordeiro, D; Inbar-Feigenberg, M; Mercimek-Mahmutoglu, S; Patel, J; Struys, E; Weiss, S, 2017) |
| "Pyridoxine-dependent seizures are a rare condition recognized when numerous seizures respond to pyridoxine treatment and recur on pyridoxine withdrawal." | 7.74 | Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology. ( Jakobs, C; Jozwiak, S; Kacinski, M; Kaczorowska, M; Kmiec, T; Kroczka, S; Salomons, GS; Struys, EA, 2008) |
| "Lysine and its metabolic intermediates were studied for their effect on pentylenetetrazol (PTZ)-induced seizures in mice." | 7.67 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "Pyridoxine-dependent seizures (PDS) is an autosomal recessive disorder characterized by seizures presenting in neonates or infants up to 3 years of age which respond to pharmacological doses of pyridoxine." | 5.35 | Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures. ( Gospe, SM; Hahn, SH; Sadilkova, K, 2009) |
| "We report treatment outcome of eleven patients with pyridoxine-dependent epilepsy caused by pathogenic variants in ALDH7A1 (PDE-ALDH7A1)." | 3.85 | Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy. ( Al Teneiji, A; Bruun, TU; Cordeiro, D; Inbar-Feigenberg, M; Mercimek-Mahmutoglu, S; Patel, J; Struys, E; Weiss, S, 2017) |
| "Pyridoxine-dependent seizures are a rare condition recognized when numerous seizures respond to pyridoxine treatment and recur on pyridoxine withdrawal." | 3.74 | Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology. ( Jakobs, C; Jozwiak, S; Kacinski, M; Kaczorowska, M; Kmiec, T; Kroczka, S; Salomons, GS; Struys, EA, 2008) |
| "Lysine and its metabolic intermediates were studied for their effect on pentylenetetrazol (PTZ)-induced seizures in mice." | 3.67 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "Pyridoxine-dependent seizures (PDS) is an autosomal recessive disorder characterized by seizures presenting in neonates or infants up to 3 years of age which respond to pharmacological doses of pyridoxine." | 1.35 | Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures. ( Gospe, SM; Hahn, SH; Sadilkova, K, 2009) |
| "Animals developed severe limbic seizures between 1 and 6 h after L-AAA injection, characterized by generalized convulsions." | 1.30 | L-alpha-aminoadipate inhibits kynurenate synthesis in rat brain hippocampus and tissue culture. ( Cauley, RK; Chang, JD; Chang, YF; Rao, VV, 1997) |
| "Experimental febrile seizures can be evoked in epileptic chicks by elevation of their body temperature." | 1.28 | Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists. ( Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, RI, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mai, HN | 1 |
| Nguyen, LTT | 1 |
| Shin, EJ | 1 |
| Kim, DJ | 1 |
| Jeong, JH | 1 |
| Chung, YH | 1 |
| Lei, XG | 1 |
| Sharma, N | 1 |
| Jang, CG | 1 |
| Nabeshima, T | 1 |
| Kim, HC | 1 |
| Yang, ZX | 1 |
| Qin, J | 1 |
| Al Teneiji, A | 1 |
| Bruun, TU | 1 |
| Cordeiro, D | 1 |
| Patel, J | 1 |
| Inbar-Feigenberg, M | 1 |
| Weiss, S | 1 |
| Struys, E | 1 |
| Mercimek-Mahmutoglu, S | 1 |
| Kaczorowska, M | 1 |
| Kmiec, T | 1 |
| Jakobs, C | 1 |
| Kacinski, M | 1 |
| Kroczka, S | 1 |
| Salomons, GS | 1 |
| Struys, EA | 1 |
| Jozwiak, S | 1 |
| Sadilkova, K | 1 |
| Gospe, SM | 1 |
| Hahn, SH | 1 |
| Vessal, M | 1 |
| Dugani, CB | 1 |
| Solomon, DA | 1 |
| McIntyre Burnham, W | 1 |
| Ivy, GO | 1 |
| Czuczwar, SJ | 2 |
| Turski, L | 2 |
| Schwarz, M | 1 |
| Turski, WA | 2 |
| Kleinrok, Z | 2 |
| Candito, M | 1 |
| Richelme, C | 1 |
| Parvy, P | 1 |
| Dageville, C | 1 |
| Appert, A | 1 |
| Bekri, S | 1 |
| Rabier, D | 1 |
| Chambon, P | 1 |
| Mariani, R | 1 |
| Kamoun, P | 1 |
| Chang, YF | 2 |
| Cauley, RK | 1 |
| Chang, JD | 1 |
| Rao, VV | 1 |
| Pedder, SC | 1 |
| Wilcox, RI | 1 |
| Tuchek, JM | 1 |
| Johnson, DD | 1 |
| Crawford, RD | 1 |
| Colton, CA | 1 |
| Colton, JS | 1 |
| Cavalheiro, EA | 1 |
| Myslinski, NR | 1 |
1 review available for 2-aminoadipic acid and Seizures
| Article | Year |
|---|---|
[Advances in clinical and molecular genetic research on pyridoxine dependent epilepsy].
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Anticonvulsants; Biomarkers; Brain; DNA Mutational Analy | 2013 |
12 other studies available for 2-aminoadipic acid and Seizures
| Article | Year |
|---|---|
Astrocytic mobilization of glutathione peroxidase-1 contributes to the protective potential against cocaine kindling behaviors in mice via activation of JAK2/STAT3 signaling.
Topics: 2-Aminoadipic Acid; Animals; Anticonvulsants; Antioxidants; Astrocytes; Calcium-Binding Proteins; Co | 2019 |
Phenotype, biochemical features, genotype and treatment outcome of pyridoxine-dependent epilepsy.
Topics: 2-Aminoadipic Acid; Adolescent; Aldehyde Dehydrogenase; Arginine; Child; Child, Preschool; Cohort St | 2017 |
Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Female; Humans; Poland; Pyridoxine; Seizures; Vitamin B | 2008 |
Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Animals; Calibration; Cattle; Child; Child, Preschool; C | 2009 |
Might astrocytes play a role in maintaining the seizure-prone state?
Topics: 2-Aminoadipic Acid; Amygdala; Animals; Astrocytes; Bromodeoxyuridine; Cell Count; Cell Proliferation | 2005 |
Effects of excitatory amino-acid antagonists on the anticonvulsant action of phenobarbital or diphenylhydantoin in mice.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Anticonvulsants; Drug Interac | 1984 |
Abnormal alpha-aminoadipic acid excretion in a newborn with a defect in platelet aggregation and antenatal cerebral haemorrhage.
Topics: 2-Aminoadipic Acid; Amino Acid Metabolism, Inborn Errors; Biopterins; Brain; Cerebral Hemorrhage; Hu | 1995 |
L-alpha-aminoadipate inhibits kynurenate synthesis in rat brain hippocampus and tissue culture.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Cells, Cultured; Drug Evaluation, Preclinical; Hippocampus; | 1997 |
Attenuation of febrile seizures in epileptic chicks by N-methyl-D-aspartate receptor antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Chickens; Diaminopimelic Acid | 1990 |
Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Animals; Anticonvulsants; Glutamates; | 1985 |
Phosphonic analogues of excitatory amino acids raise the threshold for maximal electroconvulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; Amino Acids; Amino Acids, Dicarboxylic; Animals; El | 1985 |
Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures.
Topics: 2-Aminoadipic Acid; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Lysine; Male; Mice; Pentylene | 1985 |