2-aminoadipic acid has been researched along with Neuralgia in 5 studies
2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).
2-aminoadipic acid : An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Intrathecal ketamine (10, 100, 1000 μg/kg) or LAA (10, 50, 100 nmol) alleviated SNL-induced mechanical allodynia in a dose-dependent manner respectively." | 3.76 | Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain. ( Chen, L; Li, YQ; Mei, XP; Wang, W; Wu, SX; Xu, LX; Zhang, T; Zhu, C, 2010) |
| "In contrast, intrathecal L-AA reduced neuropathic pain but not inflammatory pain in both sexes." | 1.48 | Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes. ( Berta, T; Chen, G; Ji, RR; Luo, X; Qadri, MY, 2018) |
| "The mechanical allodynia was dose-dependently attenuated by intrathecal administratration of L-α-aminoadipate (astrocytic specific inhibitor); whereas minocycline (microglial specific inhibitor) had no such effect, indicating that spinal astrocytic activation contributes to allodynia in CNP rat." | 1.39 | Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model. ( Fei, Z; Huang, G; Ji, XT; Jia, D; Li, JM; Li, XK; Niu, L; Qian, NS; Wang, P; Zhang, L; Zhang, T; Zhao, DS, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, G | 1 |
| Luo, X | 1 |
| Qadri, MY | 1 |
| Berta, T | 1 |
| Ji, RR | 1 |
| Ueda, H | 1 |
| Neyama, H | 1 |
| Nagai, J | 1 |
| Matsushita, Y | 1 |
| Tsukahara, T | 1 |
| Tsukahara, R | 1 |
| Ji, XT | 1 |
| Qian, NS | 1 |
| Zhang, T | 2 |
| Li, JM | 1 |
| Li, XK | 1 |
| Wang, P | 1 |
| Zhao, DS | 1 |
| Huang, G | 1 |
| Zhang, L | 1 |
| Fei, Z | 1 |
| Jia, D | 1 |
| Niu, L | 1 |
| Wang, W | 4 |
| Mei, X | 1 |
| Huang, J | 1 |
| Wei, Y | 1 |
| Wang, Y | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mei, XP | 1 |
| Zhu, C | 1 |
| Chen, L | 1 |
| Xu, LX | 1 |
| Wu, SX | 1 |
| Li, YQ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Auricular Point Acupressure to Manage Chemotherapy Induced Neuropathy[NCT04920097] | 240 participants (Anticipated) | Interventional | 2021-07-08 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for 2-aminoadipic acid and Neuralgia
| Article | Year |
|---|---|
Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes.
Topics: 2-Aminoadipic Acid; Animals; Anti-Inflammatory Agents; Astrocytes; Carbenoxolone; Caspase 6; Connexi | 2018 |
Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain.
Topics: 2-Aminoadipic Acid; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Chemokine CXCL1; Disease | 2018 |
Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Gene Expression; Hyperalgesia; Injections, Spinal; Interleu | 2013 |
Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Behavior, Animal; Cell Communication; Down-Regulation; Glia | 2009 |
Combining ketamine with astrocytic inhibitor as a potential analgesic strategy for neuropathic pain ketamine, astrocytic inhibitor and pain.
Topics: 2-Aminoadipic Acid; Analgesics; Animals; Astrocytes; Dose-Response Relationship, Drug; Drug Therapy, | 2010 |