2-aminoadipic acid has been researched along with Nerve Degeneration in 4 studies
2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).
2-aminoadipic acid : An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroinflammation is a contributory factor underlying the progressive nature of dopaminergic neuronal loss within the substantia nigra (SN) of Parkinson's disease (PD) patients, albeit the role of astrocytes in this process has been relatively unexplored to date." | 1.51 | L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats. ( Chiara Goisis, R; Harkin, A; Haverty, R; O'Neill, E, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'Neill, E | 1 |
| Chiara Goisis, R | 1 |
| Haverty, R | 1 |
| Harkin, A | 1 |
| Lima, A | 1 |
| Sardinha, VM | 1 |
| Oliveira, AF | 1 |
| Reis, M | 1 |
| Mota, C | 1 |
| Silva, MA | 1 |
| Marques, F | 1 |
| Cerqueira, JJ | 1 |
| Pinto, L | 1 |
| Sousa, N | 1 |
| Oliveira, JF | 1 |
| Kato, S | 1 |
| Higashida, H | 1 |
| Higuchi, Y | 1 |
| Hatakenaka, S | 1 |
| Negishi, K | 1 |
| Khurgel, M | 1 |
| Koo, AC | 1 |
| Ivy, GO | 1 |
4 other studies available for 2-aminoadipic acid and Nerve Degeneration
| Article | Year |
|---|---|
L-alpha-aminoadipic acid restricts dopaminergic neurodegeneration and motor deficits in an inflammatory model of Parkinson's disease in male rats.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Corpus Striatum; Dopaminergic Neurons; Glial Fibrillary Aci | 2019 |
Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Atrophy; Attention; Cell Death; Cognition; Dendrites; Male; | 2014 |
Sensitive and insensitive states of cultured glioma cells to glutamate damage.
Topics: 2-Aminoadipic Acid; Animals; Bucladesine; Cell Differentiation; Cell Line; Cells, Cultured; Flow Cyt | 1984 |
Selective ablation of astrocytes by intracerebral injections of alpha-aminoadipate.
Topics: 2-Aminoadipic Acid; Amygdala; Animals; Astrocytes; Brain Chemistry; Glial Fibrillary Acidic Protein; | 1996 |