2-aminoadipic acid has been researched along with Disease Models, Animal in 23 studies
2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).
2-aminoadipic acid : An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 7.74 | Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus. ( Choi, KC; Choi, SY; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS, 2008) |
| " At 4 weeks after tibia fracture and casting in rats, the cast was removed and hind paw allodynia, unweighting, warmth, and edema were measured, then the antinociceptive effects of microglia (minocycline) or astrocyte (L-2-aminoadipic acid (LAA)) inhibitors or an SP receptor antagonist (LY303870) were tested." | 3.81 | Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture. ( Clark, DJ; Guo, TZ; Kingery, WS; Li, WW; Shi, X; Sun, Y; Wei, T, 2015) |
| " We assessed the susceptibility to epilepsy after subthreshold dose of pilocarpine, as well as glial fibrillary acidic protein (GFAP) expression using immunohistochemistry." | 3.78 | Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine. ( Feng, B; Pan, XH; Sun, HL; Wang, CY; Xu, Y; Yang, LX; Zhang, SH; Zhang, SP; Zhong, K; Zhu, W, 2012) |
| "Recently we reported that astroglial loss and subsequent gliogenesis in the dentate gyrus play a role in epileptogenesis following pilocarpine-induced status epilepticus (SE)." | 3.74 | Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus. ( Choi, KC; Choi, SY; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS, 2008) |
| "We evaluated the preventive effects of a novel nonpolyglutamatable antifolate, MX-68, on two experimental murine models of systemic lupus erythematosus (SLE); NZBxNZW F1 (BWF1) mice and chronic graft-versus-host disease (GVHD) mice, in comparison with classical antifolate methotrexate (MTX)." | 3.69 | Preventive effect of a novel antifolate, MX-68, in murine systemic lupus erythematosus (SLE). ( Mihara, M; Moriya, Y; Takagi, N; Takeda, Y; Urakawa, K, 1997) |
| "In contrast, intrathecal L-AA reduced neuropathic pain but not inflammatory pain in both sexes." | 1.48 | Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes. ( Berta, T; Chen, G; Ji, RR; Luo, X; Qadri, MY, 2018) |
| " The animals were randomized into groups and were administered one of the following treatments: saline, PILO, saline+L-α-aminoadipic acid (L-AAA; one dosage tested), PILO+L-AAA, or PILO+L-methionine sulfoximine (three dosages tested)." | 1.43 | A sub-threshold dose of pilocarpine increases glutamine synthetase in reactive astrocytes and enhances the progression of amygdaloid-kindling epilepsy in rats. ( Bai, XY; Chen, XM; Deng, DP; Li, SC; Liu, YX; Pan, XH; Sun, HL; Wang, CH; Wang, CY; Zhang, XL; Zhu, W, 2016) |
| "Ocular hypertension is an important risk factor for glaucoma." | 1.43 | α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension. ( Ding, J; Han, S; Hughes, G; Li, J; Luo, H; Ma, W; Meng, Z; Su, J; Wang, X; Wang, Y; Yin, Y, 2016) |
| "In the present study, using a db/db type 2 diabetes mouse model that displayed obvious mechanical allodynia, we found that spinal astrocyte but not microglia was dramatically activated." | 1.37 | Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes. ( Cao, DY; Dou, KF; Gao, CJ; He, F; He, Y; Jia, D; Liao, YH; Qian, NS; Tao, KS; Wang, DS; Wang, P; Yang, YL; Zeng, XT; Zhang, GH; Zhang, Y, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 14 (60.87) | 24.3611 |
| 2020's | 2 (8.70) | 2.80 |
| Authors | Studies |
|---|---|
| Leandro, J | 1 |
| Dodatko, T | 1 |
| DeVita, RJ | 1 |
| Chen, H | 1 |
| Stauffer, B | 1 |
| Yu, C | 1 |
| Houten, SM | 1 |
| Yu, Y | 1 |
| Qin, Y | 1 |
| Fu, J | 1 |
| Li, Y | 1 |
| Zhang, W | 1 |
| Zhu, T | 1 |
| Jiang, L | 1 |
| Wang, X | 2 |
| Paulus, YM | 1 |
| Chen, G | 1 |
| Luo, X | 1 |
| Qadri, MY | 1 |
| Berta, T | 1 |
| Ji, RR | 2 |
| Xu, WY | 1 |
| Zhu, H | 1 |
| Shen, Y | 1 |
| Wan, YH | 1 |
| Tu, XD | 1 |
| Wu, WT | 1 |
| Tang, L | 1 |
| Zhang, HX | 1 |
| Lu, SY | 1 |
| Jin, XL | 1 |
| Fei, J | 1 |
| Wang, ZG | 1 |
| Ueda, H | 1 |
| Neyama, H | 1 |
| Nagai, J | 1 |
| Matsushita, Y | 1 |
| Tsukahara, T | 1 |
| Tsukahara, R | 1 |
| Gabriel, I | 1 |
| Kur, K | 1 |
| Laforce-Nesbitt, SS | 1 |
| Pulickal, AS | 1 |
| Bliss, JM | 1 |
| Milewski, S | 1 |
| Domin, H | 1 |
| Szewczyk, B | 1 |
| Woźniak, M | 1 |
| Wawrzak-Wleciał, A | 1 |
| Śmiałowska, M | 1 |
| Li, WW | 1 |
| Guo, TZ | 1 |
| Shi, X | 1 |
| Sun, Y | 1 |
| Wei, T | 1 |
| Clark, DJ | 1 |
| Kingery, WS | 1 |
| Sun, HL | 2 |
| Deng, DP | 1 |
| Pan, XH | 2 |
| Wang, CY | 2 |
| Zhang, XL | 1 |
| Chen, XM | 1 |
| Wang, CH | 1 |
| Liu, YX | 1 |
| Li, SC | 1 |
| Bai, XY | 1 |
| Zhu, W | 2 |
| Yu, WQ | 1 |
| Eom, YS | 1 |
| Shin, JA | 1 |
| Nair, D | 1 |
| Grzywacz, SX | 1 |
| Grzywacz, NM | 2 |
| Craft, CM | 1 |
| Lee, EJ | 2 |
| Su, J | 1 |
| Ding, J | 1 |
| Han, S | 1 |
| Ma, W | 1 |
| Luo, H | 1 |
| Hughes, G | 1 |
| Meng, Z | 1 |
| Yin, Y | 1 |
| Wang, Y | 1 |
| Li, J | 1 |
| Banasr, M | 1 |
| Duman, RS | 1 |
| Kim, DS | 1 |
| Kim, JE | 1 |
| Kwak, SE | 1 |
| Choi, KC | 1 |
| Kim, DW | 1 |
| Kwon, OS | 1 |
| Choi, SY | 1 |
| Kang, TC | 1 |
| Gao, YJ | 1 |
| Liao, YH | 1 |
| Zhang, GH | 1 |
| Jia, D | 1 |
| Wang, P | 1 |
| Qian, NS | 1 |
| He, F | 1 |
| Zeng, XT | 1 |
| He, Y | 1 |
| Yang, YL | 1 |
| Cao, DY | 1 |
| Zhang, Y | 1 |
| Wang, DS | 1 |
| Tao, KS | 1 |
| Gao, CJ | 1 |
| Dou, KF | 1 |
| Ji, Y | 1 |
| Zhu, CL | 1 |
| Lorber, B | 1 |
| Guidi, A | 1 |
| Fawcett, JW | 1 |
| Martin, KR | 1 |
| Zhang, SH | 1 |
| Feng, B | 1 |
| Zhong, K | 1 |
| Yang, LX | 1 |
| Zhang, SP | 1 |
| Xu, Y | 1 |
| Nagao, K | 1 |
| Akabane, H | 1 |
| Masuda, T | 1 |
| Komai, M | 1 |
| Tanaka, H | 1 |
| Nagai, H | 1 |
| Vessal, M | 1 |
| Dugani, CB | 1 |
| Solomon, DA | 1 |
| McIntyre Burnham, W | 1 |
| Ivy, GO | 1 |
| Mihara, M | 2 |
| Takagi, N | 2 |
| Urakawa, K | 2 |
| Moriya, Y | 1 |
| Takeda, Y | 2 |
| Kawamura, A | 1 |
| Akamatsu, K | 1 |
| Suto, C | 1 |
| Kitano, S | 1 |
| Hori, S | 1 |
23 other studies available for 2-aminoadipic acid and Disease Models, Animal
| Article | Year |
|---|---|
Deletion of 2-aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1.
Topics: 2-Aminoadipic Acid; Amino Acid Metabolism, Inborn Errors; Animals; Brain; Brain Diseases, Metabolic; | 2020 |
Long-term multimodal imaging characterization of persistent retinal neovascularization using DL-alpha-aminoadipic acid in pigmented and white rabbits.
Topics: 2-Aminoadipic Acid; Animals; Capillary Permeability; Disease Models, Animal; Excitatory Amino Acid A | 2021 |
Sex-Dependent Glial Signaling in Pathological Pain: Distinct Roles of Spinal Microglia and Astrocytes.
Topics: 2-Aminoadipic Acid; Animals; Anti-Inflammatory Agents; Astrocytes; Carbenoxolone; Caspase 6; Connexi | 2018 |
DHTKD1 Deficiency Causes Charcot-Marie-Tooth Disease in Mice.
Topics: 2-Aminoadipic Acid; Adipates; Animals; Charcot-Marie-Tooth Disease; Codon, Nonsense; Disease Models, | 2018 |
Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain.
Topics: 2-Aminoadipic Acid; Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Chemokine CXCL1; Disease | 2018 |
Phenotypic consequences of LYS4 gene disruption in Candida albicans.
Topics: 2-Aminoadipic Acid; Animal Structures; Animals; Candida albicans; Candidiasis; Colony Count, Microbi | 2014 |
Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression.
Topics: 2-Aminoadipic Acid; Animals; Antidepressive Agents; Astrocytes; Depression; Disease Models, Animal; | 2014 |
Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture.
Topics: 2-Aminoadipic Acid; Animals; Anti-Inflammatory Agents; Complex Regional Pain Syndromes; Disease Mode | 2015 |
A sub-threshold dose of pilocarpine increases glutamine synthetase in reactive astrocytes and enhances the progression of amygdaloid-kindling epilepsy in rats.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Basolateral Nuclear Complex; Catheters, Indwelling; Disease | 2016 |
Reshaping the Cone-Mosaic in a Rat Model of Retinitis Pigmentosa: Modulatory Role of ZO-1 Expression in DL-Alpha-Aminoadipic Acid Reshaping.
Topics: 2-Aminoadipic Acid; Animals; Cell Death; Disease Models, Animal; Down-Regulation; Ependymoglial Cell | 2016 |
α-Aminoadipic acid protects against retinal disruption through attenuating Müller cell gliosis in a rat model of acute ocular hypertension.
Topics: 2-Aminoadipic Acid; Animals; Apoptosis; Disease Models, Animal; Ependymoglial Cells; Gliosis; Male; | 2016 |
Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors.
Topics: 2-Aminoadipic Acid; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Cell Death; | 2008 |
Spatiotemporal characteristics of astroglial death in the rat hippocampo-entorhinal complex following pilocarpine-induced status epilepticus.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Cell Death; Cell Proliferation; Convulsants; Disease Models | 2008 |
Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia.
Topics: 2-Aminoadipic Acid; Analysis of Variance; Animals; Astrocytes; Citrates; Disease Models, Animal; Ede | 2010 |
Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease M | 2011 |
Role of Müller cells in cone mosaic rearrangement in a rat model of retinitis pigmentosa.
Topics: 2-Aminoadipic Acid; Age Factors; Animals; Animals, Newborn; Cell Communication; Cell Death; Cell Mov | 2011 |
Activated retinal glia mediated axon regeneration in experimental glaucoma.
Topics: 2-Aminoadipic Acid; Animals; Axons; Cells, Cultured; Disease Models, Animal; Glaucoma; Intraocular P | 2012 |
Reactive astrocytes contribute to increased epileptic susceptibility induced by subthreshold dose of pilocarpine.
Topics: 2-Aminoadipic Acid; Analysis of Variance; Animals; Astrocytes; Brain; Disease Models, Animal; Diseas | 2012 |
Effect of MX-68 on airway inflammation and hyperresponsiveness in mice and guinea-pigs.
Topics: 2-Aminoadipic Acid; Acetylcholine; Administration, Inhalation; Allergens; Animals; Body Weight; Bron | 2004 |
Might astrocytes play a role in maintaining the seizure-prone state?
Topics: 2-Aminoadipic Acid; Amygdala; Animals; Astrocytes; Bromodeoxyuridine; Cell Count; Cell Proliferation | 2005 |
Preventive effect of a novel antifolate, MX-68, in murine systemic lupus erythematosus (SLE).
Topics: 2-Aminoadipic Acid; Age Factors; Animals; Autoantibodies; Blood Urea Nitrogen; Cholesterol; Chronic | 1997 |
Polyglutamation of a novel antifolate, MX-68, is not necessary for its anti-arthritic effect.
Topics: 2-Aminoadipic Acid; Animals; Antineoplastic Agents; Antirheumatic Agents; Arthritis, Experimental; C | 2002 |
[An experimental model of intravitreal neovascularization in rabbits].
Topics: 2-Aminoadipic Acid; Animals; Disease Models, Animal; Fibroblast Growth Factor 2; Neovascularization, | 1992 |