2-aminoadipic acid has been researched along with Diabetes Mellitus, Type 2 in 9 studies
2-Aminoadipic Acid: A metabolite in the principal biochemical pathway of lysine. It antagonizes neuroexcitatory activity modulated by the glutamate receptor, N-METHYL-D-ASPARTATE; (NMDA).
2-aminoadipic acid : An alpha-amino acid that is adipic acid bearing a single amino substituent at position 2. An intermediate in the formation of lysine.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Obesity and type 2 diabetes (T2D) are both complicated endocrine disorders resulting from an interaction between multiple predisposing genes and environmental triggers, while diet and exercise have key influence on metabolic disorders." | 5.51 | 2-Aminoadipic acid protects against obesity and diabetes. ( Fei, J; Gao, J; Li, Z; Lu, SY; Meng, P; Shen, CL; Shen, Y; Tang, L; Wan, YH; Wang, ZG; Xu, WY; Zhang, C; Zhang, HX; Zhu, H, 2019) |
| "Insulin resistance is an important clinical feature of metabolic syndrome, which includes obesity and type 2 diabetes." | 5.51 | 2-Aminoadipic acid (2-AAA) as a potential biomarker for insulin resistance in childhood obesity. ( Jang, HB; Kim, KY; Kim, WH; Lee, HJ; Park, KJ; Park, SI, 2019) |
| "Obesity and type 2 diabetes (T2D) are both complicated endocrine disorders resulting from an interaction between multiple predisposing genes and environmental triggers, while diet and exercise have key influence on metabolic disorders." | 1.51 | 2-Aminoadipic acid protects against obesity and diabetes. ( Fei, J; Gao, J; Li, Z; Lu, SY; Meng, P; Shen, CL; Shen, Y; Tang, L; Wan, YH; Wang, ZG; Xu, WY; Zhang, C; Zhang, HX; Zhu, H, 2019) |
| "Insulin resistance is an important clinical feature of metabolic syndrome, which includes obesity and type 2 diabetes." | 1.51 | 2-Aminoadipic acid (2-AAA) as a potential biomarker for insulin resistance in childhood obesity. ( Jang, HB; Kim, KY; Kim, WH; Lee, HJ; Park, KJ; Park, SI, 2019) |
| "In the present study, using a db/db type 2 diabetes mouse model that displayed obvious mechanical allodynia, we found that spinal astrocyte but not microglia was dramatically activated." | 1.37 | Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes. ( Cao, DY; Dou, KF; Gao, CJ; He, F; He, Y; Jia, D; Liao, YH; Qian, NS; Tao, KS; Wang, DS; Wang, P; Yang, YL; Zeng, XT; Zhang, GH; Zhang, Y, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Shi, M | 1 |
| Wang, C | 2 |
| Mei, H | 1 |
| Temprosa, M | 1 |
| Florez, JC | 2 |
| Tripputi, M | 1 |
| Merino, J | 1 |
| Lipworth, L | 1 |
| Shu, XO | 1 |
| Gerszten, RE | 2 |
| Wang, TJ | 2 |
| Beckman, JA | 1 |
| Gamboa, JL | 1 |
| Mosley, JD | 1 |
| Ferguson, JF | 2 |
| Wang, S | 1 |
| Li, M | 1 |
| Lin, H | 1 |
| Wang, G | 1 |
| Xu, Y | 1 |
| Zhao, X | 1 |
| Hu, C | 1 |
| Zhang, Y | 3 |
| Zheng, R | 1 |
| Hu, R | 1 |
| Shi, L | 1 |
| Du, R | 1 |
| Su, Q | 1 |
| Wang, J | 1 |
| Chen, Y | 1 |
| Yu, X | 1 |
| Yan, L | 1 |
| Wang, T | 1 |
| Zhao, Z | 1 |
| Liu, R | 1 |
| Wang, X | 1 |
| Li, Q | 2 |
| Qin, G | 1 |
| Wan, Q | 1 |
| Chen, G | 1 |
| Xu, M | 1 |
| Dai, M | 1 |
| Zhang, D | 1 |
| Tang, X | 1 |
| Gao, Z | 1 |
| Shen, F | 1 |
| Luo, Z | 1 |
| Qin, Y | 1 |
| Chen, L | 2 |
| Huo, Y | 1 |
| Ye, Z | 1 |
| Liu, C | 1 |
| Wang, Y | 1 |
| Wu, S | 1 |
| Yang, T | 1 |
| Deng, H | 1 |
| Zhao, J | 1 |
| Lai, S | 1 |
| Mu, Y | 1 |
| Li, D | 1 |
| Xu, G | 1 |
| Ning, G | 1 |
| Wang, W | 1 |
| Bi, Y | 1 |
| Lu, J | 1 |
| Desine, S | 1 |
| Gabriel, CL | 1 |
| Smith, HM | 1 |
| Antonetti, OR | 1 |
| Calcutt, MW | 1 |
| Doran, AC | 1 |
| Silver, HJ | 1 |
| Nair, S | 1 |
| Terry, JG | 1 |
| Carr, JJ | 1 |
| Linton, MF | 1 |
| Brown, JD | 1 |
| Koethe, JR | 1 |
| Xu, WY | 1 |
| Shen, Y | 1 |
| Zhu, H | 1 |
| Gao, J | 1 |
| Zhang, C | 1 |
| Tang, L | 1 |
| Lu, SY | 1 |
| Shen, CL | 1 |
| Zhang, HX | 1 |
| Li, Z | 1 |
| Meng, P | 1 |
| Wan, YH | 1 |
| Fei, J | 1 |
| Wang, ZG | 1 |
| Lee, HJ | 2 |
| Jang, HB | 1 |
| Kim, WH | 1 |
| Park, KJ | 1 |
| Kim, KY | 1 |
| Park, SI | 1 |
| Razquin, C | 1 |
| Ruiz-Canela, M | 1 |
| Clish, CB | 2 |
| Li, J | 1 |
| Toledo, E | 1 |
| Dennis, C | 1 |
| Liang, L | 1 |
| Salas-Huetos, A | 1 |
| Pierce, KA | 2 |
| Guasch-Ferré, M | 1 |
| Corella, D | 1 |
| Ros, E | 1 |
| Estruch, R | 1 |
| Gómez-Gracia, E | 1 |
| Fitó, M | 1 |
| Lapetra, J | 1 |
| Romaguera, D | 1 |
| Alonso-Gómez, A | 1 |
| Serra-Majem, L | 1 |
| Salas-Salvadó, J | 1 |
| Hu, FB | 1 |
| Martínez-González, MA | 1 |
| Ngo, D | 1 |
| Psychogios, N | 1 |
| Dejam, A | 1 |
| Larson, MG | 1 |
| Vasan, RS | 1 |
| Ghorbani, A | 1 |
| O'Sullivan, J | 1 |
| Cheng, S | 1 |
| Rhee, EP | 1 |
| Sinha, S | 1 |
| McCabe, E | 1 |
| Fox, CS | 1 |
| O'Donnell, CJ | 1 |
| Ho, JE | 1 |
| Magnusson, M | 1 |
| Souza, AL | 1 |
| Yu, Y | 1 |
| Carter, C | 1 |
| Light, PE | 1 |
| Melander, O | 1 |
| Arora, P | 1 |
| Liao, YH | 1 |
| Zhang, GH | 1 |
| Jia, D | 1 |
| Wang, P | 1 |
| Qian, NS | 1 |
| He, F | 1 |
| Zeng, XT | 1 |
| He, Y | 1 |
| Yang, YL | 1 |
| Cao, DY | 1 |
| Wang, DS | 1 |
| Tao, KS | 1 |
| Gao, CJ | 1 |
| Dou, KF | 1 |
1 review available for 2-aminoadipic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Genetic Architecture of Plasma Alpha-Aminoadipic Acid Reveals a Relationship With High-Density Lipoprotein Cholesterol.
Topics: 2-Aminoadipic Acid; Atherosclerosis; China; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, T | 2022 |
8 other studies available for 2-aminoadipic acid and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Amino acids, microbiota-related metabolites, and the risk of incident diabetes among normoglycemic Chinese adults: Findings from the 4C study.
Topics: 2-Aminoadipic Acid; Adult; Alanine; Amino Acids; Asparagine; Diabetes Mellitus, Type 2; Glutamic Aci | 2022 |
Association of alpha-aminoadipic acid with cardiometabolic risk factors in healthy and high-risk individuals.
Topics: 2-Aminoadipic Acid; Cardiometabolic Risk Factors; Cardiovascular Diseases; Diabetes Mellitus, Type 2 | 2023 |
2-Aminoadipic acid protects against obesity and diabetes.
Topics: 2-Aminoadipic Acid; 3T3-L1 Cells; Adipose Tissue; Animals; Blood Glucose; Body Weight; Diabetes Mell | 2019 |
2-Aminoadipic acid (2-AAA) as a potential biomarker for insulin resistance in childhood obesity.
Topics: 2-Aminoadipic Acid; Adipocytes; Adipogenesis; Adipose Tissue; Adiposity; Adolescent; Animals; Biomar | 2019 |
Lysine pathway metabolites and the risk of type 2 diabetes and cardiovascular disease in the PREDIMED study: results from two case-cohort studies.
Topics: 2-Aminoadipic Acid; Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus, | 2019 |
2-Aminoadipic acid is a biomarker for diabetes risk.
Topics: 2-Aminoadipic Acid; Aged; Animals; Biomarkers; Blood Glucose; Case-Control Studies; Cell Line; Diabe | 2013 |
Metabolomics yield a novel biomarker for predicting diabetes mellitus risk in humans.
Topics: 2-Aminoadipic Acid; Animals; Diabetes Mellitus, Type 2; Female; Humans; Male | 2014 |
Spinal astrocytic activation contributes to mechanical allodynia in a mouse model of type 2 diabetes.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Disease M | 2011 |